Antibodies to Thromboplastin in Systemic Lupus Erythematosus: Isotype Distribution and Clinical Significance in a Series of 92 Patients

Font, Josep; López‐Soto, Alfons; Cervera, Ricard; Casals, F J; Reverter, Joan Carles; Muñoz, Francisco J.; Miret, C; Bové, Albert; Ordinas, A; Ingelmo, M

doi:10.1016/s0049-3848(97)00043-1

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…The presence of these antibodies has been associated with thrombosis, thrombocytopenia, hemolytic anemia, and fetal loss in SLE patients [71]. They are also correlated with lupus anticoagulant and anticardiolipin antibody presence.…”

Section: Antithromboplastin Antibodiesmentioning

confidence: 97%

Antiphospholipid Antibody-Mediated Reproductive Failure in Antiphospholipid Syndrome

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Shoenfeld

2009

Clinic Rev Allerg Immunol

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The association of elevated titers of circulating antiphospholipid (anti-PL) Abs in antiphospholipid syndrome (APS) and reproductive failure is well established in the literature. The clinical features include recurrent abortions at various stages, including implantation, placentation in the first trimester, miscarriages in the second and third trimesters, intrauterine growth retardation, preeclampsia with placental insufficiency and growth restrictions, arterial and venous thrombosis, and possibly also infertility. APS-mediated recurrent pregnancy loss and other features of reproductive failure might result from diverse autoimmune factors, inflammation, involving different mechanisms, which encompass pathogenic anti-PL Abs. Herein, we discuss the association of anti-PL Abs with reproductive failure with special emphasis on antiphospholipid autoantibodies characterizing APS. This association is evident from either human studies or murine models.

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Section: Antithromboplastin Antibodiesmentioning

confidence: 97%

Antiphospholipid Antibody-Mediated Reproductive Failure in Antiphospholipid Syndrome

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Shoenfeld

2009

Clinic Rev Allerg Immunol

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“…The presence of these antibodies has been associated with thrombosis, thrombocytopenia, hemolytic anemia and fetal loss in SLE patients. 56 They are also correlated with lupus anticoagulant and anticardiolipin antibody presence.…”

Section: Anti-thromboplastin Antibodiesmentioning

confidence: 99%

Autoantibodies associated with reproductive failure

Shoenfeld

Blank

2004

Lupus

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Autoimmune factors are involved in some of the cases of reproductive failure. These factors entail several autoantibodies, especially in patients having systemic lupus erythematosus (SLE) or the antiphospholipid syndrome (APS). These autoantibodies include mainly antibodies directed to phospholipid such as cardiolipin, phosphatidylserine, phosphatidylethanolamine or phospholipids binding glycoproteins such as beta2glycoprotein-I, annexin V, prothrombin and protein-Z. There are also some other autoantibodies directed to laminin-I, thromboplastin, mitochondrial antibodies of the M5 type, corpus luteum, prolactin, poly (ADP-ribose), thyroglobulin and more, which were also found in SLE or APS patients with reproductive failure. Moreover, the presence of additional autoantibodies directed to actin, enolase, cubilin and others, needs further investigation to support a firm association to reproductive failure in women. Future studies are likely to help to determine and expand the number of autoantibodies screened in these patients, as well as by the use of proteomics technology, to determine peptides resembling the epitope specificities associated with the specific clinical manifestations.

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“…Thromboplastin is composed of a complex of phospholipids, lipoprotein, and cholesterol, and it enables activation of coagulation factor VII upon its binding. The presence of these antibodies has been associated with thrombosis, thrombocytopenia, hemolytic anemia, and fetal loss in SLE patients (16). They are also correlated with lupus anticoagulant and anticardiolipin antibody presence.…”

Section: Antithromboplastinmentioning

confidence: 97%