Autoantibodies associated with reproductive failure

Shoenfeld, Yehuda; Blank, Miri

doi:10.1191/0961203304lu2009oa

Cited by 43 publications

(37 citation statements)

References 61 publications

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“…In the present study, the significantly higher ACL IgM positivity rate in women with primary infertility was consistent with that reported by other workers [12] [14]. This may be due to the ability of ACL antibodies to cause tiny blood clots, preventing blood from flowing to the reproductive organs or placenta [6]- [8] [19]. It has been found that the passive transfer of the purified ACL IgM antibodies was associated with lower fecundity and/or an increased rate of embryo absorptions (equivalent to primary infertility) [20].…”

Section: Discussionsupporting

confidence: 81%

Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Hasan¹,

Hwaid²,

Mahdy³

2016

JBM

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Background: Infertility is a common problem affecting 15% -20% of couples. The increased incidence of anticardiolipin (ACL) antibodies in infertile women supports the contention that these autoantibodies contribute to the infertility. Objectives: To investigate whether there is an association between the presence of serum ACL antibodies and infertility in both men and women in Diyala province. Subjects and methods: The present study was conducted in Baquba city for the period from October 2013 to November 2014. Subjects included in this study were chosen from those attending Baquba Teaching Hospital, Al-Batool Teaching Hospital for Maternity and Children and some Primary Health Care Centers in Baquba. The subjects were categorized as follows: 30 apparently healthy males with age ranged between (18 -45) years; 30 apparently healthy women (age range: 18 -47 years) had at least two live births without any miscarriages; 25 women (age range: 18 -43 years) had reproductive failure for at least one year of marriage; 30 women (age range: 24 -44 years) with at least one live birth had no pregnancy for at least two years after last child; 40 males with primary infertility (no children after at least five years of marriage and their active sperm count was zero). Detection of anti-ACL IgG and IgM was done using enzyme-linked immunosorbant assay (ELISA) commercial kits (Wendell/Shelm/Germany). All data were statistically analyzed. Results: The results revealed that the anti-ACL IgM positivity rate was significantly higher among women with primary fertility compared to healthy women (p = 0.006). Similarly, the anti-ACL IgM and anti-ACL IgG were significantly among women with secondary infertility compared to healthy women (p = 0.012) and (p = 0.038) respectively. Although the anti-ACL IgG and IgM positivity rate among men with primary infertility was higher than that of healthy control. However, the differences were failed to reach the statistical significance (p = 0.07) and (p = 0.31) respectively. Conclusion: The presence of high levels of anticardiolipin antibodies in * Corresponding author.A.-R. Sh. Hasan et al. 96women with primary and secondary infertility as well as in men with primary infertility may support the contention that these autoantibodies contribute to the infertility in both sexes.

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Section: Discussionsupporting

confidence: 81%

Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Hasan¹,

Hwaid²,

Mahdy³

2016

JBM

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“…When exposed to reactive oxygen species, LDLs undergo oxidation, a complex process that leads to formation of oxLDL and a number of products derived from lipids through peroxidation and fragmentation. Several lines of evidence support the view that oxLDLs are implicated in atherogenesis (for review, see Steinerova et al, 3 Horkko et al, 4 and Shoenfeld et al 5 ). Oxidative modification of LDL can be a prerequisite for rapid accumulation of LDL in macrophages and foam cell formation, and in vitro, oxLDLs were found to resemble biochemically and immunologically the LDL extracted from atherosclerotic lesions.…”

mentioning

confidence: 75%

Antibodies to Oxidized Low-Density Lipoproteins and Angiographically Assessed Coronary Artery Disease in White Patients

et al. 2003

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Background-Low-density lipoprotein (LDL) can be oxidatively modified by reactive oxygen species, thus generating oxLDL. The latter induce formation of specific antibodies (oxLDLAb), which are detectable in patients with atherosclerosis, in which they might play a pathogenic or a protective role. Thus, we aimed to investigate the association of antibodies with oxidized LDLs (oxLDL) (oxLDLAbs) with coronary artery disease (CAD) and acute coronary syndromes. Methods and Results-In a cross-sectional study of 529 consecutive patients undergoing quantitative coronary angiography for suspected CAD, we measured the titer of IgG oxLDLAbs by ELISA. With regression analysis techniques, we also investigated the determinants of oxLDLAb titer and the association of oxLDLAbs with CAD severity. We found no significant differences of oxLDLAb titer between groups of patients without and with different CAD severity. The oxLDLAb titer was 18.6 enzyme units (EU) (11.5 to 25.7 EU/mL) (mean, 95% CI) in patients without CAD; 16.8 EU (9.6 to 24.2 EU) in patients with stenosis Ͻ50%; and 19.9 EU (15 to 24.8 EU), 17.2 (13.8 to 20.6 EU), and 14.7 EU (12.1 to 17.3 EU) in those with in 1-, 2-, or 3-vessel Ն50% stenosis, respectively. Similarly, no differences of oxLDLAb titer between patients without and with acute coronary syndrome were found. The oxLDLAb titer correlated weakly with aging and with serum total, LDL, and HDL cholesterol and plasma homocysteine levels; however, only age and HDL cholesterol remained significant predictors of the oxLDLAb titer at a stepwise regression analysis. Conclusions-The results of this study, which was adequately powered from the statistical standpoint, provided no evidence for an association of IgG oxLDLAb titer with angiographically assessed CAD in whites. (Circulation. 2003; 108:2467-2472.)

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“…We recently reported in pregnant SLE women a strong association among HPRL, lupus anticoagulant (LA) levels, active disease, and poor pregnancy outcome (preterm birth and low birth weight) [71]. In fact, multiple autoantibodies are involved in patients with SLE and antiphospholipid syndrome with reproductive failure [72]. The association of HPRL and LA during pregnancy, and positive LA at the end of pregnancy, supports the notion that PRL is a potent immune stimulator.…”

Section: Prolactin Systemic Lupus Erythematosus and Pregnancymentioning

confidence: 90%

Prolactin and Autoimmunity

Jara

Medina

Saavedra

et al. 2009

Clinic Rev Allerg Immunol

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The relationship between prolactin and the immune system has been demonstrated in the last two decades, opening new windows in the field of the immunoendocrinology. Prolactin has an important role in the innate and adaptive immune response. Increased prolactin levels have been described in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and systemic sclerosis among others. Hyperprolactinemia is associated with active disease and organ involvement in systemic lupus erythematosus. Therefore, prolactin is an integral member of the immunoneuroendocrinology network and seems to have a role in pathogenesis of autoimmune diseases. Few controlled studies of dopamine agonist treatment in humans with autoimmune disease have been conducted only in systemic lupus erythematosus patients, which support the potential efficacy of such agents even during pregnancy and postpartum. Further studies are necessary to elucidate the mechanisms by which prolactin affects autoimmune disease activity, increase the inflammatory mechanism, and determine the role of anti-prolactinemic drugs to regulate the immune/inflammatory process.

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Autoantibodies associated with reproductive failure

Cited by 43 publications

References 61 publications

Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Antibodies to Oxidized Low-Density Lipoproteins and Angiographically Assessed Coronary Artery Disease in White Patients

Prolactin and Autoimmunity

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