Antibodies to the neuronal cytoskeleton are elicited by Alzheimer paired helical filament fractions

Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament

“…Our observation is surprisingly consistent with another study done many years ago. Fractions enriched with Alzheimer paired helical filaments from human brains induced antibodies against NFH in mice, but not against the NFL subunit (Perry et al, 1987).…”

Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases

“…The neuronal inclusions of Alzheimer's, Parkinson's, Pick's, diffuse Lewy body (DLB) diseases, and progressive supranuclear palsy (PSP), are principally composed of cytoskeletal components and share many common epitopes [6][7][8][9][10]18,20,22]. The clinical manifestations of the diseases, neuronal populations affected, and the morphology of each inclusion are distinct.…”

Microtubular reorganization and dendritic growth response in alzheimer's disease

“…In normal adult human brain, MAP2 is restricted to the somatodendritic compartment, whereas microtubule-associated tau protein is localized primarily in axons [12, 131. In AD cortex, tau immunoreactivity is dislocated from its primarily aonal domain into the somatodendritic compartment as neurofibrillary tangles (NFTs), as neurites of senile plaques, and as dystrophic neurites, a striking array of short fibers throughout the neuropil [13][14][15][16][17][18][19][20][21][22]. These specific histopathological features, when identified with traditional silver stains, define AD f23).…”