Antibodies to Seasonal Coronaviruses Rarely Cross-React With SARS-CoV-2

Abstract

Supplemental Digital Content is available in the text.

Early seasonal coronavirus seroconversion did not produce cross-protective SARS-CoV-2 antibodies

“…8 Other studies have concentrated on PCR or serological studies of hospitalized individuals which may not reflect the immunological history of the patients and cannot determine cross protection. 9,10 In conclusion, we have demonstrated that seroconversion to endemic HCoV begins early in life, increases significantly in adolescence with a slight decline in seropositivity in adulthood.…”

“… 8 Other studies have concentrated on PCR or serological studies of hospitalized individuals which may not reflect the immunological history of the patients and cannot determine cross protection. 9 , 10 …”

Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity

“…HCoVs (including beta HCoVs-HKU1 and OC43, and alpha HCoVs-NL63 and 229E) have partial sequence homology with SARS-CoV-2. 52 , 54 While cross reactive humoral responses have been shown not to underly this protection, 55 studies have reported pre-existing T cell responses to endemic HCoVs with cross-reactivity to SARS-CoV-2 in unexposed adults 50 , 56 , 57 , 58 , 59 , 60 , 61 and children. 22 , 24 , 62 , 63 These cellular responses were targeted mainly toward the S2 subunit which is highly conserved among coronaviruses.…”

Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations

“…Considering this, even though anti-HCoV antibodies were known to cross-react with SARS-CoV-2 (humoral and tissue), it was clearly demonstrated in large cohorts that antibodies against seasonal HCoVs did not produce any protection against SARS-CoV-2 [ 33 , 34 , 35 ].…”