Antibodies to Phospholipids and Nuclear Antigens in Patients with Repeated Abortions

Cowchock, Susan; Smith, J. Bruce; Gocial, Benjamin

doi:10.1097/00006254-198707000-00020

Cited by 24 publications

(31 citation statements)

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“…This frequency rate compares with the rates of 20% and 43% in other series [16,17], but at variance with others who showed no differences between patients and controls [19]. Other studies showed positive association between aCA and repeated abortions albeit with lower frequencies [4,18]. These lower frequencies might be due to the fact that they included in their studies patients with two recurrent abortions, while in our study and the other studies with comparable results, the recruited patients had a minimum of three recurrent abortions.…”

Section: Discussionsupporting

confidence: 67%

“…1993; 13 (6): [535][536][537][538][539][540] Evidence is accumulating in the literature that antibodies to negatively charged phospholipids are associated with repeated abortions and intrauterine fetal deaths [1][2][3][4][5][6]. These antibodies have also been detected in patients with systemic lupus erythematosus and other autoimmune disorders [7][8][9][10][11].…”

Section: Am Bahar T Alkarmi As Kamel V Sljivic Anticardiolipin Anmentioning

confidence: 99%

“…Some studies showed a correlation between antiphospholipid antibodies and repeated abortions [4,5,[16][17][18], while in others the association was weak or lacking [8,19]. These discrepancies mightbe due to differences between population studied.…”

Section: Am Bahar T Alkarmi As Kamel V Sljivic Anticardiolipin Anmentioning

confidence: 99%

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Anticardiolipin and Antinuclear Antibodies in Patients with Unexplained Recurrent Abortions

et al. 1993

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In a controlled study on a resident population in Kuwait, 103 patients with unexplained recurrent spontaneous abortions were investigated for the frequency of positive tests for anticardiolipin antibodies (ACA) and antinuclear antibodies (ANA). The frequency of ACA was significantly (P <0.001) higher in patients (32.0%) than in controls (7.1%). Only four patients (3.8%) were positive for both IgG and IgM ACA. The frequency of positive tests for ANA was also significantly (P <0.001) higher in patients (13.6%) than in controls (1.2%). No difference was found between first and second trimester aborters in the frequency of positive tests for either ACA or ANA. Primary aborters did not differ from secondary aborters in the frequency of ACA. However, secondary aborters had significantly higher frequency of ANA. There was no concordance between ACA and ANA positive tests. These results suggest that ACA may be associated with some cases of unexplained recurrent abortions and that tests for both IgG and IgM isotypes should be carried out in the investigations of these patients.

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Section: Discussionsupporting

confidence: 67%

Section: Am Bahar T Alkarmi As Kamel V Sljivic Anticardiolipin Anmentioning

confidence: 99%

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Anticardiolipin and Antinuclear Antibodies in Patients with Unexplained Recurrent Abortions

et al. 1993

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“…Moreover, among women with high levels of aPL, a history of prior fetal losses appears to compound the risk for further fetal demise. Increased awareness of this syndrome prompted a number of studies evaluating aPL in women with a history of recurrent fetal demise but with no known connective tissue disease (29,30). aPL levels were elevated in 13% to 42% of women with recurrent (usually three or more) miscarriages.…”

Section: Recurrent Spontaneous Abortionmentioning

confidence: 99%

Origin and pathogenesis of antiphospholipid antibodies

Celli

Gharavi

1998

Braz J Med Biol Res

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Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies that are detected in the serum of patients with a variety of conditions, including autoimmune (systemic lupus erythematosus), infectious (syphilis, AIDS) and lymphoproliferative disorders (paraproteinemia, myeloma, lymphocytic leukemias). Thrombosis, thrombocytopenia, recurrent fetal loss and other clinical complications are currently associated with a subgroup of aPL designating the antiphospholipid syndrome. In contrast, aPL from patients with infectious disorders are not associated with any clinical manifestation. These findings led to increased interest in the origin and pathogenesis of aPL. Here we present the clinical features of the antiphospholipid syndrome and review the origin of aPL, the characteristics of experimentally induced aPL and their historical background. Within this context, we discuss the most probable pathogenic mechanisms induced by these antibodies.

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“…1). These factors include anatomical disorders (2,3), chromosomal alterations and genetic causes (4-7), endocrine factors (8,9), reproductive tract infections (10) Key words: microsatellite instability, spontaneous abortions (11) or even psychological causes (12). However, a significant subset of the cases is not associated with any of the forementioned situations, indicating the presence of additional factors that confer to the recurrent rejection of the embryo.…”

Section: Introductionmentioning

confidence: 99%

Instability at Microsatellite Sequences in Spontaneously Aborted Human Embryos Provides Evidence for a Novel Mechanism for Recurrent Miscarriages

Kiaris¹,

Koumantakis²,

Ergazaki³

et al. 1995

Oncol Rep

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Abstract. Several factors have been proposed to confer a risk for abortion of the embryo. However, the aetiology of spontaneous abortions remains unclear. In the present study we investigated if an increased mutational rate occurs in the embryonic tissue and whether this phenomenon is associated with recurrent miscarriage. The mutational rate was assessed in 30 spontaneously aborted embryos using a bank of 8 highly polymorphic microsatellite markers, each one located on a different chromosome. The microsatellite sequences of DNA extracted from distal sites of each embryo were amplified by the polymerase chain reaction and the electrophoretic patterns were compared. Shifts in the mobility of the microsatellites indicating instability were scored for 12 among 30 (40%) specimens, thus suggesting that microsatellite instability (MI) is a relatively common feature of spontaneously aborted embryonic tissues. Association was found between instability and the absence of normal childbirth: 11 among 18 cases without a normal childbirth exhibited evidence of MI while only one among 12 cases with normal childbirth was positive for MI. Our results suggest that instability at microsatellite sequences which indicate decreased fidelity in DNA replication and repair are associated with the recurrent abortion of the embryo, particularly in cases without a normal childbirth.

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Antibodies to Phospholipids and Nuclear Antigens in Patients with Repeated Abortions

Cited by 24 publications

References 0 publications

Anticardiolipin and Antinuclear Antibodies in Patients with Unexplained Recurrent Abortions

Anticardiolipin and Antinuclear Antibodies in Patients with Unexplained Recurrent Abortions

Origin and pathogenesis of antiphospholipid antibodies

Instability at Microsatellite Sequences in Spontaneously Aborted Human Embryos Provides Evidence for a Novel Mechanism for Recurrent Miscarriages

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