Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study

Ursum, J.; Nielen, Markus M J; Schaardenburg, Dirkjan van; Horst, A. R. van der; Stadt, R J van de; Dijkmans, Ben A. C.; Hamann, Dörte

doi:10.1186/ar2362

Cited by 75 publications

(65 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was observed that anti-MCV autoantibodies had the highest AUC value (0.920) compared with anti-CCP and RF antibodies for RA patients since the area under a ROC curve (AUC) quantifies the overall ability of the test to discriminate between those individuals with the disease and those without the disease. In our study, specificity and sensitivity values of anti-MCV for the established RA were most comparable to the findings of Ursum et al [18]. Sahin et al [19] demonstrated that the sensitivity and specificity of anti-MCV vary in the literature between 49 and 74 % up to 79 and 96 %, respectively.…”

Section: Discussionsupporting

confidence: 90%

Unique Correlation Between Mutated Citrullinated Vimentine IgG Autoantibodies and Markers of Systemic Inflammation in Rheumatoid Arthritis Patients

et al. 2012

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is the most common inflammatory systemic autoimmune disease, primarily affecting the peripheral joints. Anti-mutated citrullinated vimentin autoantibodies (anti-MCV) of IgG isotype were shown to be a useful diagnostic marker of RA especially in RA patients who were anti-cyclic citrullinated protein autoantibodies (anti-CCP) negative. Nevertheless, published data correlates rheumatoid factor (RF), anti-CCP or anti-MCV antibodies with either erythrocyte sedimentation rate (ESR) or serum C-reactive protein (CRP) as markers of disease activity, not investigated the possible correlations of RA autoantibodies towards ESR and CRP in comparison. Herein, we aim to evaluate the usefulness of anti-MCV as a dependable marker in established RA compared with anti-CCP and RF antibodies and to examine correlations between RF, anti-CCP and anti-MCV antibodies towards ESR and serum CRP. Serum RF-IgA, RF-IgM, anti-CCP and anti-MCV levels were measured in 30 patients with RA and 40 patients with other autoimmune diseases (non-RA) compared with 20 normal subjects. Specificity, sensitivity and AUC for RF antibodies, anti-CCP and anti-MCV were calculated towards RA diagnosis. Our results showed that ESR and CRP had significantly higher values in both RA and non-RA patients compared with our healthy controls with observed significant increment in RA patients compared with non-RA patients. An important finding from our study is that 33.3 % of RA patients were anti-CCP negative but being positive towards anti-MCV. Also, in-between 36.7 up to 40 % of RA patients were RF-IgA and RF-IgM negative while being anti-MCV positive. Anti-MCV antibodies showed the highest specificity and sensitivity (97.5 and 86.6 %, respectively) towards RA diagnosis with the highest AUC value (0.920) compared with anti-CCP and RF antibodies. Correlation analyses revealed that there was no significant correlation between ESR along with CRP towards RF-IgA, RF-IgM and anti-CCP while profound highly significant correlation exhibited between ESR and CRP towards anti-MCV data (r = 0.879 and 0.994, respectively). Thus, our data suggest that the assessment of serum anti-MCV autoantibodies along with ESR and CRP considered as a simple laboratory regime for monitoring RA patients to assess and follow-up disease activity. The addition of anti-MCV autoantibodies to serologic markers in the ACR/ EULAR classification criteria for RA will add points for patients with negative anti-CCP and RF antibodies.

show abstract

Section: Discussionsupporting

confidence: 90%

Unique Correlation Between Mutated Citrullinated Vimentine IgG Autoantibodies and Markers of Systemic Inflammation in Rheumatoid Arthritis Patients

et al. 2012

View full text Add to dashboard Cite

show abstract

“…However, since no correlation coefficient was given in their study, the strength of the correlation is unknown. In a study performed on adult patients with early arthritis, Ursum et al (16) found very low correlation between anti-MCV concentrations and CRP, ESR and swollen joint count at baseline and at 1 and 2 years of follow-up. However, anti-MCV antibodies were associated with more severe RA disease, as measured by disease activity score (DAS) 28, ESR, and swollen joint count over time.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, a human recombinant mutated isoform of vimentin, citrullinated in vitro, was used in a new commercial enzyme-linked immunosorbent assay (ELISA) for detection of the respective antibodies against mutated citrullinated vimentin (anti-MCV) (12). Studies that compared the diagnostic accuracy of anti-MCV and anti-CCP antibodies in RA found comparable sensitivities, while the specificities were higher for anti-CCP in most cases (13)(14)(15)(16)(17)(18)(19). In contrast to RA, the occurrence of antibodies targeting citrullinated proteins, especially anti-MCV antibodies in rheumatic diseases of childhood, has remained largely unknown (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis

Kuna¹,

Lamot²,

Miler³

et al. 2009

Clinical Chemistry and Laboratory Medicine

View full text Add to dashboard Cite

Background: The goal of the study was to assess the presence of antibodies to mutated citrullinated vimentin (anti-MCV) and cyclic citrullinated peptides (anti-CCP) in patients with juvenile idiopathic arthritis (JIA) compared with patients with other juvenile onset rheumatic diseases. Methods: The study included 56 patients who fulfilled the International League of Associations for Rheumatology (ILAR) classification criteria for JIA, and 17 control patients with other juvenile onset rheumatic diseases. Data on six core outcome variables and the Sharp score were collected for patients with JIA. Sera and synovial fluid, if available, were tested for anti-CCP and anti-MCV antibodies using a commercial enzyme-linked immunosorbent assay (ELISA). Results: Anti-MCV antibodies were positive in 3/56 (5.4%) and anti-CCP in 1/56 (1.8%) of patients with JIA. Two out of three anti-MCV positive patients (one of them also anti-CCP positive) were found to be rheumatoid factor (RF)-positive with polyarticular disease. Within the control group, anti-MCV was positive in 4/17 (23.5%) patients, while anti-CCP positivity was not observed. No correlation between anti-MCV with anti-CCP antibody levels was found for any of the six core outcome variables or for the adapted Sharp score. Conclusions: Our results show that antibodies targeting citrullinated proteins are not a useful diagnostic marker for JIA, but can indicate severe patterns of disease in JIA. Clin Chem Lab Med 2009;47:1525-30.

show abstract

“…The objective is to develop methods with sensitivity and specifi city for earlier RA diagnosis, more reliable activity markers, and prognostic indicators. Some of the autoantibodies used in RA investigation are as follows: mutated citrullinated vimentin antibodies (anti-MCV); [49][50][51] antikeratin antibodies (AKA); anti-perinuclear factor (APF); 52 antifi laggrin autoantibodies; 53 anti-human citrullinated fi brinogen antibodies (ACF); 54 anti-heterogeneous nuclear ribonucleoprotein A2 autoantibody (anti-RA33); 52 anti-interleukin 1 antibody (anti-IL1); 55 anti-alpha-enolase antibody; 56 and anti-advanced glycation end-products antibody. 57 These antibodies have, in general, good specifi city, but sensitivity lower than that of anti-CCP for diagnosing RA.…”

Section: Other Antibodiesmentioning

confidence: 99%

Consenso da Sociedade Brasileira de Reumatologia 2011 para o diagnóstico e avaliação inicial da artrite reumatoide

Mota¹,

Cruz²,

Brenol³

et al. 2011

Rev. Bras. Reumatol.

View full text Add to dashboard Cite

Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study

Abstract: Introduction The aim of our study was to investigate the association between arthritic disease activity and antibodies to mutated citrullinated vimentin (anti-MCV), because such a relation has been suggested.

Cited by 75 publications

References 19 publications

Unique Correlation Between Mutated Citrullinated Vimentine IgG Autoantibodies and Markers of Systemic Inflammation in Rheumatoid Arthritis Patients

Unique Correlation Between Mutated Citrullinated Vimentine IgG Autoantibodies and Markers of Systemic Inflammation in Rheumatoid Arthritis Patients

Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis

Consenso da Sociedade Brasileira de Reumatologia 2011 para o diagnóstico e avaliação inicial da artrite reumatoide

Contact Info

Product

Resources

About