Antibodies to Corticotrophin and Their Relation to Adrenal Function in Children Receiving Corticotrophin Therapy

Landon, J.; Friedman, M.; Greenwood, F. C.

doi:10.1016/s0140-6736(67)92544-5

Cited by 34 publications

(16 citation statements)

References 15 publications

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“…and ranged from 5-3 to 24-7/ig./100 ml. Similar results have been obtained in children treated with this peptide (Landon, Friedman & Greenwood, 1967) and in adults receiving a combination of ACTH and synthetic corticosteroids (Amatruda et al 1960).…”

Section: Resultssupporting

confidence: 80%

A Fundamental Defect of Adrenocortical Control in Cushing's Disease

James¹,

Landon²,

Wynn³

et al. 1968

Journal of Endocrinology

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SUMMARY The plasma sugar, 11-hydroxycorticosteroid, and growth hormone responses to insulin have been studied in patients with Cushing's disease. They showed an impaired or absent plasma 11-hydroxycorticosteroid and growth hormone rise during the test, as compared with control subjects, despite the injection of amounts of insulin which produced a similar degree of hypoglycaemia. This test proved of value in differentiating between these patients and those with 'simple ' obesity since the latter usually showed a normal growth hormone and adrenal response provided an adequate amount of insulin was administered. The patients with Cushing's disease also had an impaired adrenal response to pyrogen and to dexamethasone administration and failed to show a normal plasma 11-hydroxycorticosteroid circadian rhythm. Their response to corticotrophin, lysine vasopressin, and metyrapone, however, was normal or enhanced. It is suggested that these findings imply an abnormality of hypothalamic or cerebral control and not a primary defect of pituitary function as proposed originally by Harvey Cushing. The growth hormone response to insulin remained impaired in four out of six patients totally adrenalectomized for Cushing's disease but was normal in three patients adrenalectomized for other reasons. It is suggested that the defect which impairs the adrenal response to insulin may, on occasions, also impair the mechanism normally operative for growth hormone secretion.

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Section: Resultssupporting

confidence: 80%

A Fundamental Defect of Adrenocortical Control in Cushing's Disease

James¹,

Landon²,

Wynn³

et al. 1968

Journal of Endocrinology

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“…This is in agreement with the findings of Landon et al (1967), and in contrast to the suggestion of earlier reports that acquired resistance to ACTH may have been due to antibody formation (West, 1960(West, , 1962.…”

Section: Discussionsupporting

confidence: 92%

“…Sixmonthly x-rays of the hands were also taken. During the study the serum of the patients was tested for antibodies to porcine ACTH (Landon, Friedman, and Greenwood, 1967). …”

mentioning

confidence: 99%

Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth

Zutshi¹,

Friedman²,

Ansell³

1971

Archives of Disease in Childhood

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“…In one patient (F) the anti¬ body titre exceeded that found in rabbits after immunization with bovine neuro¬ physin ; it should be noted, however, that at this stage the rabbits had been immunized for only 6 months. The antibody titres found in these patients were much higher than those produced in man in response to treatment with smaller peptide hormones such as corticotrophin (Fleischer, Abe, Liddle, Orth & Nicholson, 1967;Landon, Friedman & Greenwood, 1967) and insulin (Berson & Yalow, 1959). Production of antibodies to neurophysin is not surprising since we found that aqueous Pitressin contains neurophysin at a concentration of approximately 10 µg|m.í, and the material is given in oil as a depot preparation.…”

mentioning

confidence: 65%

Demonstration of Circulating Antibodies to Neurophysin in Patients Treated With Pitressin

Martin¹

1971

Journal of Endocrinology

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Antibodies to Corticotrophin and Their Relation to Adrenal Function in Children Receiving Corticotrophin Therapy

Cited by 34 publications

References 15 publications

A Fundamental Defect of Adrenocortical Control in Cushing's Disease

A Fundamental Defect of Adrenocortical Control in Cushing's Disease

Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth

Demonstration of Circulating Antibodies to Neurophysin in Patients Treated With Pitressin

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