Antibodies to Atlv (Htlv) in Nigerian Blood Donors and Patients With Chronic Lymphatic Leukaemia or Lymphoma

Fleming, A. F.; Yamamoto, Naoki; Bhusnurmath, S. R.; Maharajan, R.; Schneider, Josef; Hunsmann, G

doi:10.1016/s0140-6736(83)90306-9

Cited by 75 publications

(33 citation statements)

References 7 publications

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“…In Trinidad/Tobago, HTLV-I infection is restricted largely to persons of African ancestry despite the fact that the population is equally divided between persons of Asian and African origin supporting the concept that the virus is endemic in Africa (Bartholomew et al, 1985). This hypothesis was supported by our previous case report of a Nigerian with classical adult T-cell leukaemia/lymphoma (Williams et al, 1984) and recent population surveys of HTLV-I in various locales of Africa (Fleming et al, 1982;Saxinger et al, 1984;Fleming et al, 1986;Williams et al, 1987). While the validity of the early HTLV-I serology in Africa has been questioned (Weiss et al, 1986) especially because of the remarkable discrepancy between the enzyme-linked screening and confirmatory assays when compared with the more sensitive Western immunoblot assay (Constantine et al, 1988;CDC, MMWR, 1988) .…”

supporting

confidence: 59%

Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria

Williams

Alexander²,

Bodner³

et al. 1993

Br J Cancer

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supporting

confidence: 59%

Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria

Williams

Alexander²,

Bodner³

et al. 1993

Br J Cancer

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“…From seroepidemiological surveys of African people, it was found that 2~ and 3.5~ of blood donors among students in Kenya and Nigeria, respectively, were seropositive. Moreover, Fleming et al (1983) reported that lymphoma patients with anti-HTLV antibodies existed in Nigeria. Hunsmann et al (1984) extended these studies and showed that 1 to 69o of the population of several African countries, Senegal, Liberia, Nigeria, Kenya, Gabon, Zaire and South Africa, were infected with HTLV.…”

Section: Atl and Anti-htl V Antibodies Outside Japanmentioning

confidence: 99%

Viral Aetiology of Adult T-Cell Leukaemia

Yamamoto

Hinuma

1985

Journal of General Virology

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“…24,[33][34][35][36][37][38][39][40][41][42][43][44][45] To our knowledge, this study represents the first series of cutaneous T cell lymphomas reported from tropical Africa and the Sahelian region. We demonstrate that all types of CTCL, including classic mycosis fungoides, Sezary syndrome, pleomorphic CTCL and acute or smoldering adult T cell leukemia/lymphoma are present in such a geographical area.…”

Section: Discussionmentioning

confidence: 99%

“…42 Concerning ATL in tropical Africa, only rare cases with viro-immuno-molecular studies have been reported in the literature 24,33,38,52 (Table 2). A few cases of non-Hodgkin lymphomas and chronic lymphocytic leukemias have also been associated with HTLV-I based on serological data, 34,36,37 but in the absence of specific cytological and/or immuno-virological data, the etiological link between these lymphoproliferations and HTLV-I remains speculative. In our study, one typical acute ATL case with specific cutaneous T cell localizations, demonstrated HTLV-I clonal integration in the leukemic cells, which were shown to be mature activated T cells (CD4 + , CD25 + ) with a clonal TCR rearrangement.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases

et al. 1998

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Cutaneous T cell lymphomas (CTCL) are rare lymphoproliferative diseases, which are frequently suspected to be of viral origin. As very few data were available concerning cutaneous T cell lymphomas in tropical Africa, we undertook a clinical, histopathological, immunological and viro-molecular study of patients with a clinical diagnosis of cutaneous lymphoma, in Bamako, Mali. While prior to this study, no case of CTCL had been reported in this country, 14 patients (five women, nine men; mean age 58 years) with a diagnosis of cutaneous lymphoma were seen over a period of 30 months (1992-1994) in the only dermatological department in Mali. Clinically, the most frequent pattern was an infiltrated erythrodermia similar to Sezary syndrome. Nodular lesions and/or plaques were rarely observed. All these cutaneous tumors were T cell lymphoproliferations, only one expressing the CD8 + antigen. A comprehensive analysis of all the available data permitted characterization of three cases of adult T cell leukemia/lymphoma (ATL) associated with HTLV-I (one definitive case, of leukemic type, with demonstration of clonal integration of HTLV-I proviral genome and two probable ATL cases), three cases of Sezary syndrome (SS), two cases of mycosis fungoides (MF) and five cases of pleomorphic cutaneous lymphoma. In one case, the differentiation between MF and pleomorphic cutaneous lymphoma could not be established. HTLV-I serological and/or molecular markers were restricted to the three ATL cases. From the unique definitive ATL case, a T cell line was established from culture of peripheral blood mononuclear cells and sequence analysis of the env gene and the U3-LTR region demonstrated that the virus present in this patient belonged to the cosmopolitan subtype A. Thus, we report here the first evidence of HTLV-I infection and associated ATL in Mali. This is the second ATL case described for the whole Sahelian region (one ATL of the lymphoma type was reported previously in a Mauritanian patient). Furthermore, we demonstrate that the main types of CTCL described in Europe and North America are also present in this African area and that the prevalence of these diseases is greatly underestimated in such regions. Furthermore, no association was observed between HTLV-I/II infection and SS, MF or pleomorphic cutaneous lymphoma in Mali in contrast to other studies.

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Antibodies to Atlv (Htlv) in Nigerian Blood Donors and Patients With Chronic Lymphatic Leukaemia or Lymphoma

Cited by 75 publications

References 7 publications

Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria

Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria

Viral Aetiology of Adult T-Cell Leukaemia

Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases

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