Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria

Williams, Christopher K.; Alexander, S; Bodner, Anne J.; Levine, Alexandra M.; Saxinger, Carl; Gallo, RobertC.; Blattner, W. A.

doi:10.1038/bjc.1993.142

Cited by 18 publications

(11 citation statements)

References 20 publications

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“…This study is among the few that attempted to screen healthy blood donors in this environment. The first similar study in this environment was carried out in 1993 by CKO Williams et al [12] and the study showed a HTLV1-I prevalence rate of 11% among blood donors in the same blood bank [12]. The higher prevalence obtained in that study was probably due to the lower number of participants screened, theirs was 123 blood donors as against our 1000 blood donors.…”

Section: Discussionmentioning

confidence: 84%

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Seroprevalence of Human T-Cell Lymphoma/Leukemia Virus Type-1 (HTLV-1) Antibodies among Blood Donors at Ibadan, Nigeria

Yuguda¹

2017

JHVRV

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Background: Blood transfusion is an efficient mode of transmission of viruses and other infectious agents. Although human T-lymphotropic virus type 1 (HTLV-1) screening of blood donors is already routinely performed in developed countries, there is no routine screening of blood donors in our environment. As HTLV I and II are human retroviruses and are endemic in sub-Saharan African, including Nigeria, there is need to evaluate the burden of HTLV among blood donors in developing countries.

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Section: Discussionmentioning

confidence: 84%

“…Currently, routine screening of blood donors for HTLV I/II is not practiced in Nigeria. Different studies carried out in Nigeria showed varied prevalence rates for HTLV I among blood donors in Nigeria [11][12][13][14][15][16]. Prevalence rates among blood donors in in Lagos ranged from 0.7% in Lagos [17].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Human T-Cell Lymphoma/Leukemia Virus Type-1 (HTLV-1) Antibodies among Blood Donors at Ibadan, Nigeria

Yuguda¹

2017

JHVRV

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“…Development of this neoplasia appears to be associated with this transmission route 42 . A literature review shows that ATLL is quite rare in patients under 16 years of age 3,9,13,22,26,34,45,48 . The term "adult T cell leukemia/ lymphoma" may be inappropriate insofar as it does not occur only in adults.…”

Section: Discussionmentioning

confidence: 99%

Adult T-cell leukemia/lymphoma associated with HTLV-1 infection in a Brazilian adolescent

Valle

Galhardo

Leite

et al. 2001

Rev. Inst. Med. trop. S. Paulo

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“…Seis tinham idade igual ou inferior a 10 anos na época do diagnóstico 31,[77][78][79][80][81][82][83][84][85][86][87][88][89][90][91] .…”

Section: Leucemia/linfoma De Células T Do Adultounclassified

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Bittencourt¹,

Primo²,

Oliveira³

2006

J Pediatr (Rio J)

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Objectives: To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment.Sources: Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search databases were: HTLV-I-associated infective dermatitis, HTLV-Iassociated myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, HTLV-I-associated uveitis.Summary of the findings: IDH is a chronic, relapsing and infected dermatitis of childhood which always involves the scalp and which may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children and adolescents in the literature, 12 of whom are patients with IDH. In contrast with the adult form of the disease, the juvenile form is rapid and progressive. ATL is a type of T-cell leukemia/ lymphoma that affects adults and is generally fatal. Eleven of the 24 published reports of ATL in children and adolescents were diagnosed in Brazil.Conclusions: These diseases are likely to be more common in childhood and adolescence than the literature would suggest. It is advisable that serological testing be performed for HTLV-I in children and adolescents suffering from chronic and relapsing eczema, with signs and symptoms of myelopathy or with a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know how to recognize the pediatric manifestations of this infection in order to correctly diagnose them and offer their patients appropriate guidance and treatment.

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Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria

Cited by 18 publications

References 20 publications

Seroprevalence of Human T-Cell Lymphoma/Leukemia Virus Type-1 (HTLV-1) Antibodies among Blood Donors at Ibadan, Nigeria

Seroprevalence of Human T-Cell Lymphoma/Leukemia Virus Type-1 (HTLV-1) Antibodies among Blood Donors at Ibadan, Nigeria

Adult T-cell leukemia/lymphoma associated with HTLV-1 infection in a Brazilian adolescent

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

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