Antibodies in Primates to the Marburg Virus

Kalter, S. S.; Ratner, Joan J.; Heberling, R. L.

doi:10.3181/00379727-130-33476

Cited by 23 publications

(6 citation statements)

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“…Comparison of the following ex;periments was not possible, because in most caEles, the authors did not provide data on the virus concentration or appropriate controls. KALTER et al (1969) and KALTER (1971) have reported ex;periments with the same antigen. carried out their ex;periments with 20 per cent suspensions of guinea pig liver or spleen or vervet monkey liver after treatment with 0.5 per cent formalin and several ether ex;tractions.…”

Section: Complement Fixationmentioning

confidence: 87%

“…To be sure, MALHERBE (1970, 1971) agreed with KALTER et al (1969) that a high percentage of monkey sera (61 per cent) reacted with antigen from infectious guinea pig organs; but in comparative studies using antigen from infectious monkey liver only 7 of 292 baboons (Papio ursinus) and vervet monkeys (Cercopithecus aethiops pygerythrus) which had reacted with KISSLING'S antigen were found to be positive. To be sure, MALHERBE (1970, 1971) agreed with KALTER et al (1969) that a high percentage of monkey sera (61 per cent) reacted with antigen from infectious guinea pig organs; but in comparative studies using antigen from infectious monkey liver only 7 of 292 baboons (Papio ursinus) and vervet monkeys (Cercopithecus aethiops pygerythrus) which had reacted with KISSLING'S antigen were found to be positive.…”

Section: Epidemiology and Epizootiologymentioning

confidence: 90%

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Canine Distemper Virus

Appel¹,

Gillespie²,

Siegert³

1972

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Section: Complement Fixationmentioning

confidence: 87%

Section: Epidemiology and Epizootiologymentioning

confidence: 90%

Canine Distemper Virus

Appel¹,

Gillespie²,

Siegert³

1972

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“…Monkeys, on the other hand, especially those of the species Cercopithecus aethiops, had been identified as the source of infection in the case of the MBG outbreak from 1967 but regarding the high pathogenicity of the virus they were not believed to constitute the animal reservoir [35,38]. Earlier findings of MBG-positive monkey sera of African and Asian origin [20,21] could not be confirmed [36]. This situation has changed since October 1989, when a new filovirus (RES), antigenically related to EBO, was found in specimens of monkeys of the species Macaca fascicularis of Javanese origin, which suffered from hemorrhagic fever after their importation to the USA [4,16].…”

Section: Discussionmentioning

confidence: 99%

Evidence for occurrence of filovirus antibodies in humans and imported monkeys: do subclinical filovirus infections occur worldwide?

Becker

Feldmann

Will

et al. 1992

Med Microbiol Immunol

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In the present serological study 120 monkey sera from different species originating from the Philippines, China, Uganda and undetermined sources and several groups of human sera comprising a total of 1288 specimens from people living in Germany were examined for the presence of antibodies directed against filoviruses (Marburg virus, strain Musoke/Ebola virus, subtype Zaire, strain Mayinga/Reston virus). Sera were screened using a filovirus-specific enzyme-linked immunosorbent assay (ELISA). ELISA-positive sera were then confirmed by the indirect immunofluorescence technique, Western blot technique, and a blocking assay, and declared positive when at least one confirmation test was reactive. Altogether 43.3% of the monkey sera and 6.9% of the human sera reacted positively with at least one of the three different filovirus antigens. The blocking assays show that antibodies, detected in the sera, are directed to specific filovirus antigens and not caused by antigenic cross-reactivity with hitherto unknown agents. Data presented in this report suggest that subclinical filovirus infections may also occur in humans and in subhuman primates. They further suggest that filoviruses are not restricted to the African continent.

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“…Serological studies attempting to determine what monkeys and apes may be responsible for spreading or harboring this agent has led to confusion. Kissling (180,196) have found a number of simian species with CF and SN antibody to this agent. Stojkovic (325), whose laboratory was also involved in this outbreak, reported the presence of CF antibody in 90% of their surviving African green monkeys.…”

Section: Reovirusesmentioning

confidence: 99%