Antibodies from patients with dengue viral infection mediate cellular cytotoxicity

Garcı́a, Gissel; Arango, Myrtha; Pérez, Ana B.; Fonte, Luis; Sierra, Beatríz; Rodríguez-Roche, Rosmari; Aguirre, Eglys; Fiterre, I.; Guzmán, María G.

doi:10.1016/j.jcv.2006.04.010

Cited by 32 publications

(20 citation statements)

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“…The evidence of higher levels of IgG in primary DHF cases suggests additional mechanisms of immune pathogenesis. There have been reports of complement-mediated cell lysis and ADCC being important factors in dengue pathogenesis [8,28,29]. The higher level of IgG in DHF in the pre-defervescence phase suggests that it may be the early antibody response that contributes to ADE and results in the increased viremia reported in DHF [30].…”

Section: Discussionmentioning

confidence: 99%

“…Severe disease is associated more often with secondary infections but also occurs during primary infections [5]. Development of severe disease is due to multiple factors, including inflammatory cytokines [6], antibody-dependent enhancement (ADE) [7], antibodydependent cell-mediated cytotoxicity (ADCC) [8], and ADE due to antibodies produced against the prM protein [9]. An additional factor is auto-reactive antibodies produced against platelets, endothelial cells and coagulation molecules due to molecular mimicry between DENV proteins and host proteins [10].…”

Section: Introductionmentioning

confidence: 99%

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Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

et al. 2015

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Dengue hemorrhagic fever (DHF), although predominantly associated with secondary infections, has also been reported in primary infections. An enhanced immune response including antibodies and cytokines is implicated in the pathogenesis of secondary DHF. However, the factors operating in primary DHF are poorly understood. To understand the role of the antibody response, the relative levels of different antibody isotypes during the acute phase of infection in primary and secondary dengue infections were determined. Levels of DENV-specific IgM, IgG, IgA and IgE were measured in the serum samples of 200 dengue patients and 20 dengue-naïve individuals. Samples were collected within 15 days of onset of illness. The DENV-specific IgM levels were significantly higher in DF cases compared to DHF, which was more evident in secondary infections and in post-defervescence samples. The levels of IgG, IgA and IgE were higher in DHF cases, with greater significance in primary infections. A higher level of IgG in DHF cases was evident in pre-defervescence samples, whilst the IgE level was higher in pre- and post-defervescence samples. There was a significant correlation of IgG titres with platelet counts, with higher titres associated with lower platelet counts. It is speculated that IgG, IgA and IgE produced in response to primary infections may contribute to pathogenesis, whilst IgM produced in response to secondary infections may protect against progression to severe disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

et al. 2015

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“…132 Antibody-dependent cell-mediated cytotoxicity (ADCC) in pre-infection samples was associated with reduced viremia during secondary infection, 133 but others found ADCC activity in acute sera from DHF/DSS cases but not DF cases. 134 More research is needed to explore these potential additional immune correlates.…”

Section: Immune Correlates Of Protection and Riskmentioning

confidence: 99%

Dengue: knowledge gaps, unmet needs, and research priorities

Katzelnick

Coloma

Harris

2017

The Lancet Infectious Diseases

171

162

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Summary Dengue virus (DENV) is a mosquito-borne pathogen that causes up to ~100 million dengue cases each year, placing a major public health, social and economic burden on numerous low- and middle-income countries (LMICs). Major advances by scientists, vaccine developers, and affected communities are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Such research has highlighted further questions about both the basic understanding of dengue and efforts to develop new tools. We discuss existing approaches to dengue diagnostics, disease prognosis, surveillance, and vector control in LMICs as well as potential consequences of vaccine introduction. We also summarize current knowledge and recent insights into dengue epidemiology, immunology, and pathogenesis, and their implications for understanding natural infection and current and future vaccines.

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“…Although we and others have demonstrated that DV-immune serum can mediate ADCC [19,43], this is the first study, to our knowledge, to examine the relationship between preillness ADCC activity and subsequent dengue disease severity and viremia levels. ADCC correlated with serotype-specific NAb titers and anti-DV IgG1 levels in pre-secondary DV2 and DV3 infection plasma samples.…”

Section: Discussionmentioning

confidence: 85%

Antibody‐Dependent Cellular Cytotoxicity Mediated by Plasma Obtained before Secondary Dengue Virus Infections: Potential Involvement in Early Control of Viral Replication

et al. 2007

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Antibodies from patients with dengue viral infection mediate cellular cytotoxicity

Cited by 32 publications

References 13 publications

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

Dengue: knowledge gaps, unmet needs, and research priorities

Antibody‐Dependent Cellular Cytotoxicity Mediated by Plasma Obtained before Secondary Dengue Virus Infections: Potential Involvement in Early Control of Viral Replication

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