Antibody‐Dependent Cellular Cytotoxicity Mediated by Plasma Obtained before Secondary Dengue Virus Infections: Potential Involvement in Early Control of Viral Replication

Laoprasopwattana, Kamolwish; Libraty, Daniel H.; Endy, Timothy P.; Nisalak, Ananda; Chunsuttiwat, Supamit; Ennis, Francis A.; Rothman, Alan L.; Green, Sharone

doi:10.1086/512860

Cited by 58 publications

(39 citation statements)

References 43 publications

(49 reference statements)

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“…There has been renewed interest in the nonneutralizing functions of Abs during clinically important human infections, such as those involving HIV (37-41), dengue (42), and influenza viruses (24)(25)(26)(27)(28)(29)(30). In both animal models and mild-to-moderate human influenza infections, Fc-FcγR interactions aid in the clearance of influenza infection (24)(25)(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Fc functional antibodies in humans with severe H7N9 and seasonal influenza

Vanderven¹,

Liu²,

Ana-Sosa-Batiz³

et al. 2017

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Fc functional antibodies in humans with severe H7N9 and seasonal influenza

Vanderven¹,

Liu²,

Ana-Sosa-Batiz³

et al. 2017

JCI Insight

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“…The evidence of higher levels of IgG in primary DHF cases suggests additional mechanisms of immune pathogenesis. There have been reports of complement-mediated cell lysis and ADCC being important factors in dengue pathogenesis [8,28,29]. The higher level of IgG in DHF in the pre-defervescence phase suggests that it may be the early antibody response that contributes to ADE and results in the increased viremia reported in DHF [30].…”

Section: Discussionmentioning

confidence: 99%

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

et al. 2015

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Dengue hemorrhagic fever (DHF), although predominantly associated with secondary infections, has also been reported in primary infections. An enhanced immune response including antibodies and cytokines is implicated in the pathogenesis of secondary DHF. However, the factors operating in primary DHF are poorly understood. To understand the role of the antibody response, the relative levels of different antibody isotypes during the acute phase of infection in primary and secondary dengue infections were determined. Levels of DENV-specific IgM, IgG, IgA and IgE were measured in the serum samples of 200 dengue patients and 20 dengue-naïve individuals. Samples were collected within 15 days of onset of illness. The DENV-specific IgM levels were significantly higher in DF cases compared to DHF, which was more evident in secondary infections and in post-defervescence samples. The levels of IgG, IgA and IgE were higher in DHF cases, with greater significance in primary infections. A higher level of IgG in DHF cases was evident in pre-defervescence samples, whilst the IgE level was higher in pre- and post-defervescence samples. There was a significant correlation of IgG titres with platelet counts, with higher titres associated with lower platelet counts. It is speculated that IgG, IgA and IgE produced in response to primary infections may contribute to pathogenesis, whilst IgM produced in response to secondary infections may protect against progression to severe disease.

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“…Regarding antibody isotypes, IgG 1 and IgG 3 differed significantly between DF and DHF cases, while IgG 4 and IgA were more common in DSS cases. 132 Antibody-dependent cell-mediated cytotoxicity (ADCC) in pre-infection samples was associated with reduced viremia during secondary infection, 133 but others found ADCC activity in acute sera from DHF/DSS cases but not DF cases. 134 More research is needed to explore these potential additional immune correlates.…”

Section: Immune Correlates Of Protection and Riskmentioning

confidence: 99%

Dengue: knowledge gaps, unmet needs, and research priorities

Katzelnick

Coloma

Harris

2017

The Lancet Infectious Diseases

171

162

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Summary Dengue virus (DENV) is a mosquito-borne pathogen that causes up to ~100 million dengue cases each year, placing a major public health, social and economic burden on numerous low- and middle-income countries (LMICs). Major advances by scientists, vaccine developers, and affected communities are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Such research has highlighted further questions about both the basic understanding of dengue and efforts to develop new tools. We discuss existing approaches to dengue diagnostics, disease prognosis, surveillance, and vector control in LMICs as well as potential consequences of vaccine introduction. We also summarize current knowledge and recent insights into dengue epidemiology, immunology, and pathogenesis, and their implications for understanding natural infection and current and future vaccines.

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Antibody‐Dependent Cellular Cytotoxicity Mediated by Plasma Obtained before Secondary Dengue Virus Infections: Potential Involvement in Early Control of Viral Replication

Abstract: ADCC may contribute to the early control of secondary DV3 viremia in vivo.

Cited by 58 publications

References 43 publications

Fc functional antibodies in humans with severe H7N9 and seasonal influenza

Fc functional antibodies in humans with severe H7N9 and seasonal influenza

Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever

Dengue: knowledge gaps, unmet needs, and research priorities

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