Antibodies from Other Species

Vadnais, Melissa L.; Criscitiello, Michael F.; Smider, Vaughn V.

doi:10.1002/9783527699124.ch4

Cited by 3 publications

(2 citation statements)

References 138 publications

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“…The immunoglobulins Utilization of Immunoglobulin Y (IgY) as Alternatives to Laboratory Animals in Human and Veterinary Medical Practice: A Review are broadly categorized into various types viz.,IgM, IgG, IgD, IgE, IgA, IgD2, IgNAR, IgW, IgX, IgY, IgT and HCAbs based on structure, type of chain arrangements and molecular weight. The presence of various immunoglobulins in animals are species specific (Vadnais et al, 2017).…”

Section: Immunoglobulinsmentioning

confidence: 99%

Utilization of Immunoglobulin Y (IgY) as Alternatives to Laboratory Animals in Human and Veterinary Medical Practice: A Review

Naveenkumar

Nag

Porteen

et al. 2022

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Emerging infectious diseases and antibiotic resistance impose major threats to animals and humans throughout the world. The Emergence of various infectious and pandemic diseases alarms the need for prophylactic and therapeutic regimens in protecting both animals and humans. Hence, researchers are trying to identify newer methodologies to overcome the existing issues for better immune response and antibiotic resistance. In this view, chicken immunoglobulin Y (IgY) has gained momentum due to its role in prophylactic, therapeutic and diagnostic modalities with varying success rate. In an unpredictable and contagious COVID-19 like situations, the role of passive immunization through chicken immunoglobulin has turned to be important for controlling infectious disease transmission. This review focus on the immunoprophylactic and immunotherapeutic role of IgY in human and animal diseases and to explore the use of IgY for veterinary and human medicine.

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Section: Immunoglobulinsmentioning

confidence: 99%

Utilization of Immunoglobulin Y (IgY) as Alternatives to Laboratory Animals in Human and Veterinary Medical Practice: A Review

Naveenkumar

Nag

Porteen

et al. 2022

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“…Furthermore, even though chickens have homologs for mammalian IgM and IgA, they are not able to generate IgD and IgE at all. It is nonetheless believed that mammalian IgE functions may be replaced by avian IgY (142,143).…”

Section: B Cell Lineage and The Antibody Repertoire Generationmentioning

confidence: 99%

The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies

Garcia

Wang²,

Viallet³

et al. 2021

Front. Immunol.

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Dysregulation of the immune system is associated with many pathologies, including cardiovascular diseases, diabetes, and cancer. To date, the most commonly used models in biomedical research are rodents, and despite the various advantages they offer, their use also raises numerous drawbacks. Recently, another in vivo model, the chicken embryo and its chorioallantoic membrane, has re-emerged for various applications. This model has many benefits compared to other classical models, as it is cost-effective, time-efficient, and easier to use. In this review, we explain how the chicken embryo can be used as a model for immune-based studies, as it gradually develops an embryonic immune system, yet which is functionally similar to humans’. We mainly aim to describe the avian immune system, highlighting the differences and similarities with the human immune system, including the repertoire of lymphoid tissues, immune cells, and other key features. We also describe the general in ovo immune ontogeny. In conclusion, we expect that this review will help future studies better tailor their use of the chicken embryo model for testing specific experimental hypotheses or performing preclinical testing.

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