Antibodies Against Chlamydia of Lymphogranuloma-Venereum Type in Crohn's Disease

Schuller, JC; Veeken, I.V.D.; Ulsen, J. van; Michel, M. F.; Stolz, E.

doi:10.1016/s0140-6736(79)90457-4

Cited by 48 publications

(11 citation statements)

References 2 publications

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“…Although some investigators have found high IgG antibody titres against Chlamydia trachomatis in patients with IBD, especially CD, other studies yield con icting results (94,95). At the present time, there is no convincing evidence for an association between IBD and infection with Chlamydia trachomatis (96).…”

Section: Chlamydia Trachomatismentioning

confidence: 74%

The Bacterial Flora in Inflammatory Bowel Disease: Current Insights in Pathogenesis and the Influence of Antibiotics and Probiotics

Linskens

Huijsdens

Savelkoul

et al. 2001

Scandinavian Journal of Gastroenterology

193

122

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Linskens RK, Huijsdens XW, Savelkoul PHM, Vandenbroucke-Grauls CMJE, Meuwissen SGM. The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics. Scand J Gastroenterol 2001;36 Suppl 234:29-40.The pathogenesis of in ammatory bowel disease (IBD) remains unknown, although in recent years more data have become available. The contribution of genetic and environmental factors is evident, and the luminal bacterial ora plays a major role in the initiation and perpetuation of chronic IBD. Animal models of IBD have shown that colitis does not occur in a germ-free environment. In human IBD, in ammation is present in parts of the gut containing the highest bacterial concentrations. Moreover, the terminal ileum, caecum and rectum are areas of relative stasis, providing prolonged mucosal contact with luminal contents.Enhanced mucosal permeability may play a pivotal role in maintaining a chronic in ammatory state, due to a genetic predisposition or as a result of direct contact with bacteria or their products. A defective epithelial barrier may cause a loss of tolerance to the normal enteric ora. Furthermore, an increased mucosal absorption of viable bacteria and bacterial products is found in IBD. Serum and secreted antibodies are increased and mucosal T-lymphocytes that recognize luminal bacteria are present. However, there is evidence that the immune system reacts over aggressively towards the normal luminal ora rather than the ora being altered in IBD. Several approaches have been used in attempts to discover a speci c microbial agent in the cause of IBD. These include demonstration of the presence of organisms or speci c antigens in affected tissues, culture of microbes from the affected tissues, demonstration of serological responses to several agents, and localization and detection of individual pathogen-speci c nucleic acid sequences in affected tissue by in situ hybridization and polymerase chain reaction. So far, no speci c micro-organism has been directly associated with the pathogenesis of IBD. Analysis of the luminal enteric ora, however, has revealed differences in the composition of this ora compared to healthy controls. In Crohn disease, concentrations of Bacteroides, Eubacteria and Peptostreptococcus are increased, whereas Bi dobacteria numbers are signi cantly reduced. Furthermore, in ulcerative colitis, concentrations of facultative anaerobic bacteria are increased. The arrival of new molecular techniques qualifying and quantifying the complex intestinal ora has induced a revival of interest in this micro ora.Therapeutic approaches geared towards changing the environment at the mucosal border have been attempted by the use of elemental diets, total parenteral nutrition, surgical diversion of the faecal stream and antibiotics. Over the past few years, the use of probiotics in IBD and other intestinal disorders has gained attention. Strengthened by promising experimental data and commercial interests, research in this eld is rapidly expandin...

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Section: Chlamydia Trachomatismentioning

confidence: 74%

The Bacterial Flora in Inflammatory Bowel Disease: Current Insights in Pathogenesis and the Influence of Antibiotics and Probiotics

Linskens

Huijsdens

Savelkoul

et al. 2001

Scandinavian Journal of Gastroenterology

193

122

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“…The good result in the first 16 wk may have been due to concomitant administration of a tapering course of prednisolone, which can have non-specific bacterial effects. Numerous other specific bacteria have been proposed as candidate causative agents of CD, including Pseudomonas maltophilia [75] , Mycobacterium kansasii [76] , Chlamydia trachomatis [77] , Bacteroides fragilis [78] and Listeria monocytogenes [79] . Like MAP, P maltophilia and M kansasii were first isolated from CD tissues as L-forms.…”

Section: The Unidentified Persistent Pathogen Theorymentioning

confidence: 99%

Evidence for the involvement of infectious agents in the pathogenesis of Crohn’s disease

Hertogh

Aerssens²,

Geboes³

et al. 2008

WJG

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“…Under the conditions described above we could routinely detect 0-5 pg of chiamydial plasmid pLGV440 DNA against a background of [5][6][7][8][9][10] .tg of human gut DNA extract (see Fig 2). This is equivalent to 6x 104 plasmids.…”

Section: Sensitivity Of the Hybridisation Assaymentioning

confidence: 99%

Deoxyribonucleic acid amplification and hybridisation in Crohn's disease using a chlamydial plasmid probe.

Mcgarity

Robertson

Clarke

et al. 1991

Gut

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Antibodies Against Chlamydia of Lymphogranuloma-Venereum Type in Crohn's Disease

Cited by 48 publications

References 2 publications

The Bacterial Flora in Inflammatory Bowel Disease: Current Insights in Pathogenesis and the Influence of Antibiotics and Probiotics

The Bacterial Flora in Inflammatory Bowel Disease: Current Insights in Pathogenesis and the Influence of Antibiotics and Probiotics

Evidence for the involvement of infectious agents in the pathogenesis of Crohn’s disease

Deoxyribonucleic acid amplification and hybridisation in Crohn's disease using a chlamydial plasmid probe.

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