Antibiotics prior to embryo transfer in ART

Kroon, Ben; Hart, Roger; Wong, Brittany; Ford, Emily; Yazdani, Anusch

doi:10.1002/14651858.cd008995.pub2

Cited by 42 publications

(23 citation statements)

References 15 publications

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“…The use of antibiotics has been widely studied to treat BV and prevent preterm birth (reviewed in []). But the usefulness of antibiotic use before embryo transfer remains controversial; while it is efficient in reducing upper genital tract contamination, no beneficial role has been observed in pregnancy outcome . This can be due to the lack of specificity of broad‐spectrum antibiotics that could impair not only the growth of dysbiotic bacteria, but also the protective Lactobacilli .…”

Section: Role Of Bacteria In Human Reproductionmentioning

confidence: 99%

Deciphering the effect of reproductive tract microbiota on human reproduction

Moreno

Simón

2018

Reprod Medicine & Biology

107

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BackgroundThe female reproductive tract contains an active microbiome comprising mainly bacteria from the Lactobacillus genus, which is associated with a healthy microbiome state. However, spatio‐temporal fluctuations of this microbiome that occur in response to internal and external factors may impact the physiology of the reproductive tract organs and even lead to pathological states.MethodsCurrent literature covering the reproductive tract microbiome is summarized and contextualized in this review.Main findingsThis review presents the current knowledge about the bacterial composition of the lower and upper reproductive tract as well as the impact of the microbiota on women's health and reproduction. We place special focus on the impact of the endometrial microbiome in infertility and assisted reproductive technologies.ConclusionThe assessment of the reproductive tract microbiome adds a new microbiological perspective to human reproduction, pregnancy, and onset of new life, highlighting the importance of considering the evaluation of microbial communities to improve personalized care in reproductive medicine and women's health.

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Section: Role Of Bacteria In Human Reproductionmentioning

confidence: 99%

Deciphering the effect of reproductive tract microbiota on human reproduction

Moreno

Simón

2018

Reprod Medicine & Biology

107

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“…A recent Cochrane review analyzed randomized controlled trials in the literature that investigated antibiotics at embryo transfer (36). Only four potential studies were identified, of which three were excluded.…”

Section: Figurementioning

confidence: 99%

“…Although administration of antibiotics reduced microbial contamination as defined by culture of embryo transfer catheter tips, the clinical pregnancy rate was 36% in those receiving antibiotics and 35.5% in those not receiving antibiotics (odds ratio 1.02, 95% confidence interval 0.66-1.58) (37). The reviewers concluded that more evidence is needed with live birth as the primary outcome (36).…”

Section: Figurementioning

confidence: 99%

Reproductive tract microbiome in assisted reproductive technologies

Franasiak

Scott

2015

Fertility and Sterility

120

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The human microbiome has gained much attention recently for its role in health and disease. This interest has come as we have begun to scratch the surface of the complexity of what has been deemed to be our "second genome" through initiatives such as the Human Microbiome Project. Microbes have been hypothesized to be involved in the physiology and pathophysiology of assisted reproduction since before the first success in IVF. Although the data supporting or refuting this hypothesis remain somewhat sparse, thanks to sequencing data from the 16S rRNA subunit, we have begun to characterize the microbiome in the male and female reproductive tracts and understand how this may play a role in reproductive competence. In this review, we discuss what is known about the microbiome of the reproductive tract as it pertains to assisted reproductive technologies.

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“…Endometrial implantation is the single most important event determining the success of embryo transfer in assisted reproductive therapy (ART) (2). Other factors include the presence of microbial colonization of the upper genital tract (3) and possibly utero-cervical microbial colonization (4), which has been shown to be an independent and significant factor determining the success of assisted reproductive treatments (5).…”

Section: Introductionmentioning

confidence: 99%

The Impact Of The Vaginal And Endometrial Microbiome Pattern On Assisted Reproduction Outcomes

Carratalá‐Munuera

Martínez

García

et al. 2020

Preprint

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Background:The vaginal microbiome plays an important role in maintaining health, and there is evidence that microbial colonization of the upper genital tract can also influence successful embryo transfer. The aim of this study is to determine whether the vaginal and endometrial microbiome in people undergoing assisted reproduction techniques could affect the pregnancy rate. Results:Regarding the microbiome dynamics during the cycle, we observed a decrease in alpha diversity from the follicular to luteal phase in the control group, in contrast to a stable pattern in the repetitive implantation failure group. As for endometrial and vaginal microbiome, alpha diversity was higher in the endometrium (Shannon p = 0.0139, Simpson p = 0.046); differences were also observed in beta diversity (p = 0.001). Compared to the endometrium, the vagina showed a greater relative abundance of Lactobacillus spp. (83.17% vs 84.82%, p < 0.0001), Streptococcus spp. (1.59% vs 7.74%, p = 0.014) and Ureaplasma spp. (0% vs. 0.89%, p = 0.006), and a lower abundance of Delftia spp. (0.95% vs 0%, p = 0.0003), Anaerobacillus spp. (1.59% vs 0%, p = 0.0004), and Ralstonia spp. (3.17% vs 0%, p = 0.0006). We also observed differences in both alpha diversity (Shannon p = 0.0206, Simpson p = 0.0206) and beta diversity between groups, along with differences for Ralstonia spp. (0.09% study group and 0.73% control, p = 0.0012). Finally, the relative abundance of Lactobacillus spp. differed between patients that did not versus did achieve pregnancy (91% vs 99%, p = 0.0445 visit 1, 94.63% vs. 97.69%, p = 0.0268 visit 2, 97.73% vs 99.74%, p = 0.0492 visit 3). The relative abundance of L.reuteri was also different between groups (0.39% vs 0.17%, p = 0.0397 visit 1, 0.15% vs 0.30%, p = 0.0491 visit 3). Conclusions:The vaginal and endometrial microbiome pattern correlates with the pregnancy rate, and it is different in patients who do versus do not have repetitive implantation failures. No significant differences in the composition of the microbiome were observed through the different visits. The lack of dynamism in the microbiome pattern of repetitive implantation failure patients might reflect an

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Antibiotics prior to embryo transfer in ART

Abstract: Bacteriological catheter analysis was performed on 284 of 350 women randomised. In the antibiotic arm 154/178 (86.5%) were analysed. In the control arm, 130/172 (75.6%) were analysed.

Cited by 42 publications

References 15 publications

Deciphering the effect of reproductive tract microbiota on human reproduction

Deciphering the effect of reproductive tract microbiota on human reproduction

Reproductive tract microbiome in assisted reproductive technologies

The Impact Of The Vaginal And Endometrial Microbiome Pattern On Assisted Reproduction Outcomes

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