Antibiotics and Fungous Infections1

Lipnik, Morris J.; Kligman, Albert M.; Strauss, Richard E.

doi:10.1038/jid.1952.28

Cited by 57 publications

(6 citation statements)

References 25 publications

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“…In addition, the observation that C. albicans could not be isolated from feces of normal conventional mice agrees with findings of others (13,14,21,28).…”

Section: Discussionsupporting

confidence: 92%

Influence of Antibiotics or Certain Intestinal Bacteria on Orally Administered Candida albicans in Germ-Free and Conventional Mice

Clark

1971

Infect Immun

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Candida albicans, administered by gastric intubation, persisted in the gastrointestinal tract of gnotobiotic mice for long periods but was eliminated within a relatively short period of time in pathogen-free mice. Oxytetracycline administered by mouth had no reproducible effect on the persistence of C. albicans in the gastrointestinal tract of either germ-free or pathogen-free mice. Prolonged administration of streptomycin extended the time that C. albicans could be recovered from feces of pathogen-free mice when compared to mice not receiving the antibiotic or those receiving a single large dose. There was a brief interval of time during which C. albicans could not be recovered from the feces of gnotobiotic mice contaminated with certain intestinal bacteria, but eventually all mice began to shed the fungus again. C. albicans administered by mouth was not pathogenic for germ-free or pathogen-free mice. It can be concluded from these findings that mice do not possess an innate resistance to C. albicans but that pathogen-free mice do possess some ecological mechanism which prevents establishment of the fungus in their gastrointestinal tract. The reason for the difference in colonization of C. albicans in germ-free or gnotobiotic mice and pathogen-free mice was not determined.

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“…In addition, the observation that C. albicans could not be isolated from feces of normal conventional mice agrees with findings of others (13,14,21,28).…”

Section: Discussionsupporting

confidence: 92%

Influence of Antibiotics or Certain Intestinal Bacteria on Orally Administered Candida albicans in Germ-Free and Conventional Mice

Clark

1971

Infect Immun

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“…This observation is not supported by the work of McVay and Sprunt. 40 Lipnik and his associates 39 have shown that dibasic sodium phosphate will stim¬ ulate the growth of the yeast, and this parallels our findings with one medium and not with another. Since Czapek's medium without sodium nitrate supported growth when dibasic calcium phosphate was added and not with dibasic sodium phosphate, it would appear that the calcium was more important than the sodium or the phos¬ phate.…”

Section: General Commentsupporting

confidence: 89%

Candida (Monilia) Albicans

Johnson¹

1954

AMA Arch Derm Syphilol

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“…Whether the broad-spectrum antibiotics directly stimulate the growth of Candida in vitro is a moot point, on which contradictory evidence has been presented. Some of the studies on the effect of antibiotics on pure cultures of Candida have shown pure chlortetracycine to increase the growth of Candida (23,72,105), others showed no effect (93,96), and still others attributed the enhancing effect to a substance other than the antibiotic (i.e., dicalcium phosphate) in the capsule preparation (84,117). Although penicillin, streptomycin, or broadspectrum antibiotics enhanced Candida growth in some studies (21,22,67,69) they had no effect in others (23,67,96).…”

Section: Effect Of Antibiotics On C Albicansmentioning

confidence: 99%