Candida (Monilia) Albicans

Johnson, Sture A. M.

doi:10.1001/archderm.1954.01540190051003

Cited by 45 publications

(11 citation statements)

References 32 publications

(9 reference statements)

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“…Glucose is a highly utilisable substrate for C. albicans, both in culture media [5] and in human saliva [6], and it has been suggested that the competition for glucose between the yeast and bacteria plays a major role in preventing overgrowth of the yeast [7]. Candidosis occurs more often when there is high availability of glucose, as in persons with diabetes and in patients receiving total parenteral nutrition [8].…”

Section: Introductionmentioning

confidence: 99%

Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat

2000

Journal of Medical Microbiology

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The competition for glucose as a growth-limiting substrate between Candida albicans and a mixed community of oral bacteria was investigated. A chemostat was operated under glucose-limiting and glucose excess conditions at a dilution rate of 0.05/h. A mixed population of oral bacteria was established and after a steady state had been reached the chemostat was inoculated with C. albicans. Seven bacterial species ± Streptococcus sanguis, S. sobrinus, S. mitis, Lactobacillus casei, Veillonella dispar, Eubacterium saburreum and Fusobacterium nucleatum ± were able to establish stable populations under glucose-limiting conditions. The yeast was unable to grow with the bacteria under glucose limitation. Only three bacterial species, S. sobrinus, L. casei and E. saburreum, became established under glucose-excess conditions. C. albicans was also able to become established in the glucose-excess chemostat and could grow and maintain a steady state in a mixed culture with these organisms. L. casei, S. mitis and S. sobrinus had faster glucose consumption rates than C. albicans. All the bacteria, except for F. nucleatum, had maximum speci®c growth rates higher than C. albicans. The results suggest that glucose may act as a growth-limiting substrate for C. albicans in the establishment and growth of the yeast in a mixed community of oral bacteria.

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Section: Introductionmentioning

confidence: 99%

Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat

2000

Journal of Medical Microbiology

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“…The rate of growth of C. albicans rises in proportion to the concentration of glucose present, when this is above 150 mg./100 ml. (Johnson, 1954).…”

Section: Discussionmentioning

confidence: 99%

Pseudohyperparathyroidism with Carcinoma of Bronchus

Fry¹

1962

BMJ

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“…Candida species are among the majority of pathogens that, unlike e.g., Clostridium tetani, can only cause disease if they grow and replicate for many generations. During growth in human tissues, Candida cells must withstand host environmental conditions very unlike their growth optima: Temperatures ≥36 • C, nutrient deprivation especially for glucose and phosphate, microaerophilic or anaerobic environments, and pH 7.35-7.45 [11]. They must additionally resist host immune cells like neutrophils and macrophages that actively deploy oxidative, nitrosative and cationic stressors, as well as cell wall stress [12].…”

Section: Phosphate Is Indispensable For C Albicans Growth a Precondmentioning

confidence: 99%

Phosphate in Virulence of Candida albicans and Candida glabrata

Köhler

Acosta-Zaldívar

2020

JoF

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Candida species are the most commonly isolated invasive human fungal pathogens. A role for phosphate acquisition in their growth, resistance against host immune cells, and tolerance of important antifungal medications is becoming apparent. Phosphorus is an essential element in vital components of the cell, including chromosomes and ribosomes. Producing the energy currency of the cell, ATP, requires abundant inorganic phosphate. A comparison of the network of regulators and effectors that controls phosphate acquisition and intracellular distribution, the PHO regulon, between the model yeast Saccharomyces cerevisiae, a plant saprobe, its evolutionarily close relative C. glabrata, and the more distantly related C. albicans, highlights the need to coordinate phosphate homeostasis with adenylate biosynthesis for ATP production. It also suggests that fungi that cope with phosphate starvation as they invade host tissues, may link phosphate acquisition to stress responses as an efficient mechanism of anticipatory regulation. Recent work indicates that connections among the PHO regulon, Target of Rapamycin Complex 1 signaling, oxidative stress management, and cell wall construction are based both in direct signaling links, and in the provision of phosphate for sufficient metabolic intermediates that are substrates in these processes. Fundamental differences in fungal and human phosphate homeostasis may offer novel drug targets.

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Candida (Monilia) Albicans

Cited by 45 publications

References 32 publications

Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat

Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat

Pseudohyperparathyroidism with Carcinoma of Bronchus

Phosphate in Virulence of Candida albicans and Candida glabrata

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