Antibiotic Susceptibility of Conjunctival Bacterial Isolates from Refractive Surgery Patients

Chung, J. N.; Seo, Kyoung Yul; Dan, Yong; Mah, Francis S.; Kim, Tae Im; Kim, Eung Kweon; Kim, Jin Kook

doi:10.1016/j.ophtha.2008.12.064

Cited by 40 publications

(31 citation statements)

References 40 publications

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“…[16][17][18][19][20] These agents provide coverage against most Gram-negative and Gram-positive bacteria, good ocular penetration, low toxicity, safety, and commercial availability. 21 Hence, even though several cases of fluoroquinolone resistance have been published, 18,22,23 our results show that, based on the susceptibility results for this geographic region, quinolones are still a good choice for paediatric bacterial keratitis in the Eastern China area, just as the susceptibility test in the current study showed. In addition, the first-generation cephalosporin, cefazolin, had a low level of antibacterial efficacy.…”

Section: Discussionmentioning

confidence: 45%

Paediatric bacterial keratitis cases in Shanghai: microbiological profile, antibiotic susceptibility and visual outcomes

Hong

Chen

Sun

et al. 2012

Eye

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Purpose The purpose of this study was to review the microbiological profile, in vitro antibiotic susceptibility and visual outcomes of paediatric microbial keratitis in Shanghai, China over the past 6 years. Methods Medical records of patients aged r16 years were reviewed, who were diagnosed as having bacterial keratitis between 1 January 2005 and 31 December 2010. Bacterial culture results and in vitro antibiotic susceptibility were analysed. A logistic regression analysis was conducted to evaluate the relationship between visual impairment and possible risk factors. Results Eighty consecutive cases of paediatric bacterial keratitis cases were included, among which 59 were identified as having positive culture. Staphylococcus epidermidis was the most commonly isolated organism (n ¼ 23; 39.0%), followed by Streptococcus pneumoniae (n ¼ 11; 18.6%) and Pseudomonas aeruginosa (n ¼ 6; 10.2%). Antibiotic sensitivities revealed that tested bacteria had low resistance rates to fluoroquinolones and aminoglycosides (8.3-18.4% and 12.5-24.4%, respectively). Multivariate logistic regression analysis proved that visual impairment was significantly associated with Gram-negative bacterial infection (odds ratio (OR) ¼ 7.626; P ¼ 0.043) and an increasing number of resistant antibiotics (OR ¼ 0.385; P ¼ 0.040). Conclusions S. epidermidis was the most common isolated organism in Shanghai paediatric keratitis. The fluoroquinolones and aminoglycosides remained good choices for treating these patients. Gram-negative bacterial infection and an increasing number of resistant antibiotics were associated with worse visual prognoses in paediatric keratitis.

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Section: Discussionmentioning

confidence: 45%

Paediatric bacterial keratitis cases in Shanghai: microbiological profile, antibiotic susceptibility and visual outcomes

Hong

Chen

Sun

et al. 2012

Eye

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“…[18][19][20][21] In performing a sample size calculation, we anticipated an increase in resistance from approximately 5% to 20% based on a documented resistance change of second-and third-generation fluoroquinolones of approximately 15%. With a power of 0.8 and an ␣ of .05, we estimated that 142 patients would be required.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“…With a power of 0.8 and an ␣ of .05, we estimated that 142 patients would be required. To account for a coagulase-negative Staphylococcus culture-positive rate of 84.9%, 21 the recruitment size was adjusted to 168 patients (84 patients in each study arm).…”

Section: Sample Size Calculationmentioning

confidence: 99%

Antibiotic Resistance of Ocular Surface Flora With Repeated Use of a Topical Antibiotic After Intravitreal Injection

Yin¹,

Weisbrod²,

Eng³

et al. 2013

JAMA Ophthalmol

100

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“…11 The published literature reports methicillin or oxacillin resistance in CoNS from normal conjunctiva of patients to range from 20% to 47%. 10,[19][20][21][22] The rate in the present cohort of patients is higher, approximately 55%. 11 On the basis of in vitro susceptibility data alone, nearly one third of the eyes in the present study received inadequate prophylaxis with the use of fluoroquinolones.…”

Section: Discussionmentioning

confidence: 52%

Assessment of risk factors for oxacillin-resistant ocular flora in eyes having cataract surgery

Hsu¹,

Lind²,

Miller³

et al. 2015

Journal of Cataract and Refractive Surgery

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Antibiotic Susceptibility of Conjunctival Bacterial Isolates from Refractive Surgery Patients

Cited by 40 publications

References 40 publications

Paediatric bacterial keratitis cases in Shanghai: microbiological profile, antibiotic susceptibility and visual outcomes

Paediatric bacterial keratitis cases in Shanghai: microbiological profile, antibiotic susceptibility and visual outcomes

Antibiotic Resistance of Ocular Surface Flora With Repeated Use of a Topical Antibiotic After Intravitreal Injection

Assessment of risk factors for oxacillin-resistant ocular flora in eyes having cataract surgery

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