Antibiotic sensitivity pattern of common bacterial pathogens in NICU and neonatal ward in Hamedan province of Iran

Abstract

Bacterial pathogens and drug resistance are different in hospitals of each country. In this study we determined bacterial path- ogens and drug sensitivity in the neonatal ward and neonatal intensive care unit (NICU) in Ekbatan hospital in Hamedan. This cross-sectional descriptive study was done on 1150 hospitalized neonates in neonatal and NICU wards of Ekbatan hospital of the Hamadan university of medical sciences from September 2004 to September 2006. Blood, cerebrospinal fluid (CSF), urine, stool, eye excretion, synovial fluid, umbilical secretion and ascitic fluid were evaluated. Positive cultures were evaluated for antibiotic resistance with disk diffusion test methed. All of the data in questionnaires was analyzed with SPSS 13. Cultures including blood, urine, CSF , stool, eye excretion, synovial fluid, umbilical secretion and ascitic fluid was done in 417 neonates (833 cultures). These cultures were including: urine, 323 cases (38.8%) blood 293 cases (35.2%), CSF 180 cases (21.6%) , stool 17 cases (2%), eye secretion 16 cases (1.9%) and other secretions (synovial, umbilical, etc) 4 cases (0.5%). The cultures were positive in 105 cases (25.2%). 60 male neonates (57.1%) and 45 female neonates (42.9%) were culture positive. The most common microorganisms were E coli 66.7% (70 cases), Klebsiella 10.5% (11 cases). Drug resistance was high in these microorganisms. The most common microorganisms were Ecoli and klebsiella. Drug resistance was high in the isolated microorganisms

Bacterial Etiologies and Antibiotic Susceptibility Pattern of Urinary Tract Infections at the Pediatric Ward of Dastgheib Hospital, Shiraz, Iran: A Three-Year Study (2009 - 2011)

“…Based on Monsef and Eghbalian research, S. saprophyticus was the most Gram-positive isolated bacteria in the urine culture; this is similar to the results of the present research (11). However, the antibiotic susceptibility pattern was opposite so that in our research vancomycin and nitrofurantoin were the most effective antibiotics, and cotrimoxazole was the less effective antibiotic for S. saprophyticus while in the study of Monsef and Eghbalian these bacteria were sensitive to co-trimoxazole and resistant to vancomycin.…”

“…Likewise, many scientists reported E. coli as common pathogenic isolates in UTI (12,(19)(20)(21); however, in some geographic regions such as Nigeria (Ebonyi State university teaching hospital, Children's emergency unit, age group between birth to five years old) Klebsiella spp was reported as the main factor of UTI in children (22). In Iran, Monsef and Eghbalian and Mirsoleymani et al reported Klebsiella spp as the second factor for UTI besides E. coli (Ekbatan hospital of the Hamadan University of Medical Sciences, neonatal and neonatal intensive care unit, age group between one to 30 days), as shown in our study (11,16). Furthermore, some scientists indicated that Klebsiella spp is more isolated from boys with UTIs; it is hypothesized that etiological agents of urinary tract infection vary between both genders (23).…”

“…However, the antibiotic susceptibility pattern was opposite so that in our research vancomycin and nitrofurantoin were the most effective antibiotics, and cotrimoxazole was the less effective antibiotic for S. saprophyticus while in the study of Monsef and Eghbalian these bacteria were sensitive to co-trimoxazole and resistant to vancomycin. However, S. saprophyticus was resistant to cephalexin in both studies (11). The review of the patients' information showed that the most common antibiotic, which was prescribed by physicians for hospitalized children with UTI before obtaining a culture result, was ceftriaxone.…”

“…Delay in diagnosis and appropriate treatment is the cause of complication in the upper genitourinary system (5). There has been an increase in the rate of antibiotic resistant bacteria associated with UTI in pediatric wards (4,11,12). Also exchange of antibiotic resistance genes among the uropathogenes causes multi-drug resistance to antibiotics (13).…”

Drug utilization study in neonatal intensive care unit of a tertiary care teaching hospital

“…Most common organisms found in our study were E. coli (40), Klebsiella (16) and Pseudomonas (17), which is in accordance with other studies done where Klebsiella and E.coli were the most common organisms. 18,19 In our study, No.…”