“…In Spain, Hungary, and South Africa, very high rates of penicillin resistance have been found in both colonizing and invasive isolates (9,25). The 17% frequency of diminished sensitivity to penicillin documented in this study is significantly higher than rates reported in Uruguay (3%) (20), Pakistan (12%) (11), and South Africa (12%) (26). Serotypes 6,14,19, and 23 have been associated with resistance to penicillin or multiple drugs.…”