Antibiotic susceptibility of Streptococcus pneumoniae colonizing the nasopharynx of Colombian children with pneumonia

Leal, Aura Lucía; Castañeda, Elizabeth

doi:10.1590/s1020-49891997001000005

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…DSP has been associated with different types worldwide, the most important ones being 6, 14, 19, and 23.4,7,9,12,15,19 17, respectively. Lanes 15,16,17,18,19 (reference strains for international clone B): UR 135, penicillin-resistant serotype 14 strain from France, UR-318, MEX-HIM 15, MEX-HIM 24, respectively. Lanes 7,8,9,10,11: isolates COLA 14, 13, 48, 252, and 242, respectively (representatives of international clone A).…”

Section: Discussionmentioning

confidence: 99%

Penicillin-ResistantStreptococcus pneumoniaein Colombia: Presence of International Epidemic Clones

Castañeda

Peñuela²,

Vela³

et al. 1998

Microbial Drug Resistance

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The global spread of multidrug-resistant Streptococcus pneumoniae clones is well documented in the literature. A study to determine type distribution and antimicrobial susceptibility of invasive pneumococcal isolates from Colombian children under the age of 5 was conducted from 1994 to 1996. Health centers in Santa Fe de Bogota, Medellin, Cali, and other cities collected 409 Streptococcus pneumoniae isolates. Diminished susceptibility to penicillin (DSP) was 15.6%; from these, 11.5% showed intermediate-level resistance (ILR) and 4.1% showed high-level resistance (HLR). Fifty-nine of the DSP isolates were examined by pulse field gel electrophoresis (PFGE). Capsular isolate types were 23F (54%), 14 (24%), 19F (10%), 6B (7%), 9V (3%), and 34 (2%). PFGE analysis revealed that 8 isolates shared the Spanish/USA international clone's characteristic features: PFGE pattern type A, serotype 23F; 87.5% exhibited HLR for penicillin, and all were resistant to trimethoprim/sulfamethoxazole (TMP-SMX), tetracycline, and chloramphenicol. Another 7 isolates showed the French/Spanish international clone's features: PFGE pattern type B, 2 of them being serotype 9V; and 5 type 14; HLR to penicillin was 71%, and all proved resistant to TMP-SMX. A large cluster of 24 isolates (41% of all isolates examined) shared a common PFGE type C, with 14 subtypes; all but one, serotype 34, were serotype 23F and had ILR to penicillin; 58% were resistant to TMP-SMX and 50% to tetracycline, but none presented erythromycin or chloramphenicol resistance. The remaining 20 isolates could be grouped into 12 different PFGE types; ILR was shown in 75% of isolates, 70% were resistant to TMP-SMX and to tetracycline, 15% were resistant to erythromycin, and none were resistant to chloramphenicol. These data suggest that some Colombian isolates are clonally related to two of the well-known international epidemic S. pneumoniae clones.

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Section: Discussionmentioning

confidence: 99%

Penicillin-ResistantStreptococcus pneumoniaein Colombia: Presence of International Epidemic Clones

Castañeda

Peñuela²,

Vela³

et al. 1998

Microbial Drug Resistance

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“…Bronchial colonization can be found in lung cancer patients mainly caused by S. pneumoniae along with Haemophilus influenza and Staphylococcus aureus (19). Streptococcus pneumoniae has shown an increased resistance towards various antibiotics (20).…”

Section: Introductionmentioning

confidence: 99%

Colonization of Streptococcus pneumoniae in Pneumonia Patients with Lung Cancer

Zhou

Zhao

2017

Jundishapur J Microbiol

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Background: Lung cancer is the most common cancer and the leading cause of cancer deaths. Streptococcus pneumoniae is the most common pathogen found among lung cancer patients that has shown increased resistance towards various antibiotics. Reports on bacterial colonization especially S. pneumoniae colonization in patients with lung cancer are scarce. Objectives: The study aimed to determine the prevalence and antibiotic resistance of S. pneumoniae isolated from lung cancer patients with pneumonia infection not undergoing any surgical procedure. Methods: Bronchoalveolar lavage (BAL) and blood samples for blood culture and PCR were collected from 152 lung cancer patients with pneumonia. Blood culture and BAL specimens were cultured to isolate S. pneumoniae and antibiotic resistance was determined by minimum inhibitory concentration assay. Results: Of the 152 blood samples, 85 (55.9%) samples from blood culture method and 97 (63.8%) samples from BAL specimens were positive for bacterial growth. Streptococcus pneumoniae was the predominant organism isolated from both blood culture (45.9%) and BAL (46.4%) specimens. Forty-seven (30.9%) samples were found to be positive for S. pneumoniae by PCR. The detection of S. pneumoniae in 60 patients by at least one of the 3 detection methods indicates that these patients harbored S. pneumoniae infection. Fifteen (9.9%) patients died due to the severity of pneumonia, rapid progression of lung cancer, multiple therapeutic failures, and unknown etiology. All our isolates were susceptible to penicillin; however, 48.7% and 60% of the isolates respectively from blood culture and BAL specimens were found to be resistant to erythromycin. Conclusions: Streptococcus pneumoniae was the predominant organism colonized in lung cancer patients diagnosed to have pneumonia and showed higher resistance towards erythromycin. Our results emphasize the need for a continuous monitoring of S. pneumoniae colonization and resistance patterns, which needs to be considered during treatment of lung cancer patients with pneumonia.

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“…One third of such cases are resistant to many antibiotics. 11,12 Every year in developing countries, some 4.5 million persons, most of them less than 5 years of age, die of ARI. Most ARI episodes are caused by viral agents and are selflimiting, but the bacterial pneumonias, which occur less frequently, carry a much higher risk of complications and death.…”

Section: Introductionmentioning

confidence: 99%

“…To cover the possibility of undiagnosed pneumococcal pneumonia, WHO guidelines for the management of ARI include empirical use of antimicrobial agents such as procaine Penicillin, Ampicillin and Cotromoxazole. 11 For treatment of pneumonia, appropriate antibiotic should be given for 5 days. The choice of antibiotic is based on the fact that most childhood pneumonia of bacterial origin is due to streptococcus pneumoniae or haemophilus influenzae.…”

Section: Introductionmentioning

confidence: 99%

Prescribing Pattern of Antimicrobials used in Under Five Years Children in Cough or Cold and Pneumonia in Outdoor Settings of Two Tertiary Level Hospital

Begum

Ahmed

Saha

et al. 2014

Bangladesh J Physiol Pharmacol

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This descriptive type of cross-sectional study was conducted in MMCH and CBMCB during the period from 1 st July/2005 to 30 th Jun/2006.The aim of the study was to find out the prescribing pattern of antimicrobials in cough or cold and pneumonia in under five years children. Prescriptions were collected from the out-patient pediatric department by using structured questionnaire. The structured questionnaires were made according to WHO/ INRUD drug use indicator. In case of cough or cold, the main findings on drug use were (a) Average number of drugs per prescription were 3.21 in MMCH and 3.85 in CBMCB respectively, (b) Percentage of prescriptions with an antibiotic prescribed was 100% in MMCH and CBMCB, (c) Percentage of drugs prescribed in generic name were 57.69% in MMCH and it was nil in CBMCB, (d) Cotrimoxazole, Amoxicillin and Cephalosporin were used frequently in MMCH and Cephalosporin and Erythromycin mostly were used in CBMCB, and (e) Route of administration were appropriate in both the institutes. In case of pneumonia, (a) Average number of drugs per prescription were 3.77, (b) Percentage of prescription with an antibiotic was 100%, (c) Percentage of drug prescribed in generic name was 27.5%, (d) Cephalosporin were used mostly (45.5%) for the treatment of pneumonia. Trend of poly pharmacy was found in both the institutes.

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Antibiotic susceptibility of Streptococcus pneumoniae colonizing the nasopharynx of Colombian children with pneumonia

Cited by 7 publications

References 21 publications

Penicillin-ResistantStreptococcus pneumoniaein Colombia: Presence of International Epidemic Clones

Penicillin-ResistantStreptococcus pneumoniaein Colombia: Presence of International Epidemic Clones

Colonization of Streptococcus pneumoniae in Pneumonia Patients with Lung Cancer

Prescribing Pattern of Antimicrobials used in Under Five Years Children in Cough or Cold and Pneumonia in Outdoor Settings of Two Tertiary Level Hospital

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