Antibiotic Resistance Profile of Gram Negative Bacteria Isolated from Surgical Wounds in Minna, Bida, Kontagora and Suleja Areas of Niger State

Sani, Rehana Abdullah; Garba, S.; Oyewole, Oluwafemi Adebayo

doi:10.5923/j.ajmms.20120201.05

Cited by 23 publications

(10 citation statements)

References 6 publications

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“…However, contrary to our findings, many authors have reported higher level of resistance among infected wound isolates to aminoglycosides [2,22,24,50,51]. Aside from haphazard use of these drugs in those set ups, bacteria are able to resist the action of aminoglycosides via: i).…”

Section: Discussioncontrasting

confidence: 90%

Identification and antimicrobial susceptibility profile of bacterial pathogens isolated from wound infections in a tertiary hospital, Bayelsa, South southern, Nigeria

Abdu

Egbagba

Fente

2019

Trop J Pathol Microbiol

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Introduction: Infected wounds in particular, those associated with antimicrobial resistant microorganisms constitute a significant source of physical, psychological, and economic burden to patients in particular, and the society at large in terms of the huge resources spent in treating such wounds as well as time/days lost at workplaces leading to increased morbidity and mortality globally. The present study sought to investigate and identify the common bacteria associated with wound infections and their antibiotic sensitivity pattern. Material and Methods: A total of 130 wound samples were collected by doctors in ward using Sterile Swab Sticks over a period of 6 months from February-July 2019. Pathogenic bacteria were isolated, identified and their antibiotic susceptibility tests were performed. Results: Among 130 cases, 108 (83.08%) were culture positive for bacterial pathogens, while 22 (16.92%) were bacteriologically sterile (Negative). Rate of infection was high in males (56.15%) than females (43.85%). Of the 108-culture positive, 164 isolates were recovered of which 28 (17.07) were anaerobes, while 136 were aerobes of which 106 (64.64%) were Gram-negative species and 30 (18.29%) Gram-negative species. The predominant isolates among the facultative aerobes, were Pseudomonas aeruginosa 28 (17.07%), followed by E. coli 19 (11.58%), Klebsiella pneumonia 17 (10.37%) while the least were amongst Morganella morgani, Providencia rettgeri and Serretia marcescens with 2 (1.22%) individually. Among the Gram-positive, Staphylococcus aureus 10 (6.10%) were most common, followed by Enterococcus spp 4 (2.44%), Coagulase negative staphylococcus (CoNS) 4 (2.44%) while the least were amongst Streptococcus Group B, Streptococcus Group C, Streptococcus Group G with 2 (1.22%) separately. Amongst the anaerobes, Bacterioides fragilis 16 (9.75%) is the most common, followed by Peptostreptococcus spp., and Prevotella spp with 4 (2.44%) each, while Fusobacterium spp and Veillonella spp were the least, 2 (1.22%) each. Amikacin and nitrofurantoin are the most efficacious for managing wound infections, with all the isolates being susceptible to them. Resistance was moderate to Levofloxacin (49.39%). On the other hand, resistance were above average among Ciprofloxacin (96.34%), Cloxacillin (94.51%), Ceftriaxone (91.46%), Ceftazidine (91.46%), Cefotaxime (87.20%), Erythromycin (59.15%), Ofloxacin (58.54%) and Chloramphenicol (51.22%). The least resistance shown to Gentamicin (16.46%), Streptomycin (16.46%), Imipenem (7.93%), Metronidazole (7.93%), and Piperacillin-tazobactam (7.93%). Conclusion: Antibiotic susceptibility test is suggested prior to administration of antibiotics for successful treatment and intermittent monitoring is also encouraged to check emerging multidrug resistant trends as a guide to health authorities.

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Section: Discussioncontrasting

confidence: 90%

Identification and antimicrobial susceptibility profile of bacterial pathogens isolated from wound infections in a tertiary hospital, Bayelsa, South southern, Nigeria

Abdu

Egbagba

Fente

2019

Trop J Pathol Microbiol

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“…In contrast, S. aureus showed very high sensitivity to cefotaxime, vancomycin, and ciprofloxacin. These findings are in consistent with the study of Adcock et al, 18 and Sani et al, 19 who recorded that pathogenic Staphylococci are resistant to several antibiotics. Resistance of this bacterium to erythromycin group tends to develop so rapidly.…”

Section: Discussionsupporting

confidence: 93%

Effect of Most Common Antibiotics Against Bacteria Isolated From Surgical Wounds in Aden Governorate Hospitals, Yemen

et al. 2020

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Objective: The increased antibiotics resistance of pathogenic bacteria isolated from surgical wound is the major health threats challenge the patients especially in developing countries like Yemen. This work was aimed to determine and identify the bacteria associated with surgical wound infections and their resistance to commonly used antibiotics. Methods: One hundred and twenty swabs were sampled from surgical wound patients at Aden City, Yemen. The pathogenic bacteria were isolated and identified according to standard microbiological methods. Also, antibiotic susceptibility tests were determining by using Kirby-Bauer disc diffusion technique. Results: The results showed that out of 120 samples, 68 (56.67%) showed bacterial growth. It was found that the most isolated bacteria was Sylococcus aureus 27 (39.70%) followed by Escherichia coli 19(27.94%), Pseudomonas aeruginosa 13 (19.12%), and Proteus mirabilis 9 (13.24%). All isolated bacteria were recorded to be extremely resistant to the most tested antibiotics. S. aureus was reported to be susceptible to cefotaxime, vancomycin, and ciprofloxacin and highly resistant to ceftazidime, nalidixic acid, erythromycin, and tetracycline. The E. coli isolates showed resistance (100%) to vancomycin and tetracycline and moderately sensitive to ceftazidime and gentamycin. P. aeruginosa showed from high to moderate resistance to most tested antibiotics except gentamycin and cefotaxime. Most of P. mirabilis isolates were sensitive to ceftazidime, cefotaxime, ciprofloxacin, and gentamycin and highly resistant to amoxicillin, erythromycin, and vancomycin. Conclusion: The current study findings that the reduced sensitivity of isolated bacteria to commonly used antibiotics is an alarming and threat upsurge of infections caused by antibiotic-resistant bacteria. Peer Review History: Received 27 January 2020; Revised 15 February; Accepted 1 March, Available online 15 March 2020 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Name: Dr. Mujde Eryilmaz Affiliation: Ankara University,Turkey E-mail: meryilmaz@ankara.edu.tr Name: Rola Jadallah Affiliation: Arab American University, Palestine E-mail: rola@aauj.edu Comments of reviewer(s): Similar Articles: BACTERIAL CONTAMINATION OF DIALYSIS WATER AND DIALYSATE AT MUKALLA ARTIFICIAL KIDNEY CENTER IN MUKALLA CITY - HADHRAMAUT - YEMEN: RATE OF CONTAMINATION AND SENSITIVITY OF BACTERIAL ISOLATES TO ANTIBIOTICS BIOFILM FORMATION AND ANTIBIOTIC SUSCEPTIBILITY OF UROPATHOGENS IN PATIENTS WITH CATHETER ASSOCIATED URINARY TRACT INFECTIONS IN IBB CITY -YEMEN ANTIMICROBIAL ACTIVITIES FOR HADHRAMI HONEY ON GROWTH OF SOME PATHOGENIC BACTERIA

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“…The common wound pathogens include bacteria, fungi, protozoa, and viruses [13]. Common bacterial pathogens associated with wound infection include Staphylococcus aureus , Escherichia coli, Pseudomonas aeruginosa , Klebsiella pneumoniae , Streptococcus pyogenes , Proteus species, Streptococcus species, and Enterococcus species [12, 14, 15]. …”

Section: Introductionmentioning

confidence: 99%

“…The antibiotics resistant pathogens are acquired from either health care setting environment, health care personnel, or inpatients [20]. Hospital-acquired infections are further complicated by increasing prevalence of multidrug resistant bacterial pathogens like methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase negative Staphylococcus (CoNS), vancomycin-resistant Enterococcus (VRE), and polymicrobial flora and fungi [14]. …”

Section: Introductionmentioning

confidence: 99%

Bacterial Isolates and Their Antimicrobial Susceptibility Patterns of Wound Infections among Inpatients and Outpatients Attending the University of Gondar Referral Hospital, Northwest Ethiopia

Mohammed¹,

Endris

Gebrecherkos

et al. 2017

International Journal of Microbiology

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Background. The widespread uses of antibiotics, together with the length of time over which they have been available, have led to the emergence of resistant bacterial pathogens contributing to morbidity and mortality. This study was aimed to assess bacterial isolates and their drug susceptibility patterns from inpatients and outpatients with pus and/or wound discharge. Methods. A cross-sectional study was conducted at the University of Gondar Referral Hospital from March to May, 2014. Wound swab samples were collected from each study participant and inoculated into appropriate media. The bacterial pathogens were identified using standard microbiological methods. Antimicrobial susceptibility tests were performed using disk diffusion technique following Kirby-Bauer method. Results. A total of 137 study subjects were included in the study with bacterial isolation rate of 115 (83.9%). Of all, 81 (59.1%) were males. Seventy-seven (57%) of the isolates were Gram-negative and 59 (43%) were Gram-positive. From the total isolates, Staphylococcus aureus was the most predominant isolate 39/115 (34%) followed by Klebsiella species (13%), coagulase negative staphylococci spp. (12%) and Pseudomonas aeruginosa. Gram-positive isolates were resistant to ampicillin (86.4%), amoxicillin (83%), penicillin (81.3%), oxacillin (74.6%), and tetracycline (59.4%), while Gram-negative isolates were resistant to amoxicillin (97.4%), ampicillin (94.8%), tetracycline (72.7%), trimethoprim/sulfamethoxazole (66%), and chloramphenicol (54.5%). Conclusion. High prevalence of bacterial isolates was found, Staphylococcus aureus being the most dominant. High rates of multiple drug resistance pathogens to the commonly used antimicrobial agents were isolated. Therefore, concerned bodies should properly monitor the choice of antibiotics to be used as prophylaxis and empiric treatment in the study area.

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Antibiotic Resistance Profile of Gram Negative Bacteria Isolated from Surgical Wounds in Minna, Bida, Kontagora and Suleja Areas of Niger State

Cited by 23 publications

References 6 publications

Identification and antimicrobial susceptibility profile of bacterial pathogens isolated from wound infections in a tertiary hospital, Bayelsa, South southern, Nigeria

Identification and antimicrobial susceptibility profile of bacterial pathogens isolated from wound infections in a tertiary hospital, Bayelsa, South southern, Nigeria

Effect of Most Common Antibiotics Against Bacteria Isolated From Surgical Wounds in Aden Governorate Hospitals, Yemen

Bacterial Isolates and Their Antimicrobial Susceptibility Patterns of Wound Infections among Inpatients and Outpatients Attending the University of Gondar Referral Hospital, Northwest Ethiopia

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