Antibiotic resistance profile of common uropathogens during COVID-19 pandemic: hospital based epidemiologic study

Abstract

Background Antimicrobial resistance has a direct impact on the ability to treat common infections, and this was worsened during the COVID-19 pandemic. Worldwide surveillance studies are lacking and resistance rates vary spatially, so frequent local surveillance reports are required to guide antimicrobial stewardship efforts. This study aims to report our common local uropathogens and their antibiogram profiles in our community during the COVID era. Methods A retrospective study included patients referred to our urology units with urine culture and sensitivity. All bacterial strains were identified, and their antibiotic susceptibilities were tested. Results Out of 2581 urine culture results recruited, 30% showed microbiological proof of infection. The majority, 486 (63.4%), were isolated from females. The most frequent isolates were Escherichia coli (44.4%) and Staphylococcus aureus (17.8%). The resistance rates ranged from 26.9 to 79.7%. Piperacillin-tazobactam antibiotic had the lowest resistance rate. The multi-drug resistance pattern was recorded in 181 (23.9%) of the isolates; 159/597 (26.6%) Gram-negative and 22/160 (13.8%) Gram-positive isolates. Conclusions Alarming rates of antimicrobial resistance were detected, which stresses the significance of following infection control policies and establishing national antimicrobial stewardship standards.

Characterization and Antimicrobial Susceptibility Patterns of Enterococcus Species Isolated from Nosocomial Infections in a Saudi Tertiary Care Hospital over a Ten-Year Period (2012–2021)

“…Despite the fact that the COVID-19 pandemic was the primary cause of increased and inappropriate antimicrobial use [30], our study found no conclusive evidence of a rising trend of antimicrobial resistance as a result of the pandemic. Other studies have produced conflicting results, with some indicating that the pandemic was associated with an increase in VRE infection or colonization [31] while others discovered a decrease in VRE resistance during the COVID-19 pandemic [4,32].…”

The Prevalence of Multidrug-Resistant Uropathogenic Bacterial Profile With Antibiotic Susceptibility Patterns Among the Community and Hospitalized Patients During COVID Waves

“…Enterococcus spp . showed high resistance (100%) to clindamycin and teicoplanin, which is similar to the findings of Abdel Gawad et al [ 33 ]. Gram-positive bacteria showed considerably high resistance rates to Antibiotics in this study, which is incompatible with the investigation conducted by Ahmed et al [ 23 ].…”

Antibiotic Resistance Trends in Uropathogens during the COVID-19 Pandemic in Western Romania: A Cross-Sectional Study

“…Similar trends in antimicrobial resistance have been observed, such as substantial resistance rates to ciprofloxacin of 65% for Escherichia coli and 62% for Klebsiella pneumoniae and a 38% resistance rate to carbapenems for Klebsiella pneumoniae reported in Italy [ 34 ]. These figures underscore the heightened challenge of managing drug-resistant infections, intensified by the pandemic’s impact on antibiotic prescribing practices [ 35 ], and highlight the critical need for robust antimicrobial stewardship.…”