Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

Wang, Changzhen; Wang, Min-Ge; Chu, Yiu-Wai; Sun, Ruan-Yang; Li, Jianguo; Li, Xianan; Sun, Jian; Liu, Ya-Hong; Zhou, Yu; Liao, Xiao‐Ping

doi:10.1128/spectrum.00309-23

Cited by 6 publications

(7 citation statements)

References 64 publications

(86 reference statements)

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“…Regarding quinolones, the resistance levels obtained were considered intermediate since the AMR values for ENRO and DANO were 49% and 60.9%, respectively. Notably, in all studies encompassing any of these antimicrobials [ 44 , 45 , 47 , 54 , 55 , 56 , 58 ] the resistance levels were considerably lower than those observed in this study. Specifically, the resistances detected were 2%, 9.6%, 1.4%, 11.1%, 2%, 11.5%, and 1%, respectively.…”

Section: Discussioncontrasting

confidence: 80%

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Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022

Petrocchi Rilo,

Gutiérrez Martín,

Acebes Fernández

et al. 2024

Veterinary Sciences

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This study aimed to update the Streptococcus suis serotype distribution in Spain by analysing 302 clinical isolates recovered from diseased pigs between 2020 and 2022. The main objectives were to identify prevalent serotypes, differentiate specific serotypes 1, 14, 2, and 1/2, investigate specific genotypic and phenotypic antimicrobial resistance features, and explore associations between resistance genes and phenotypic resistances. Serotypes 9 (21.2%), 1 (16.2%), 2 (15.6%), 3 (6%), and 7 (5.6%) were the most prevalent, whereas serotypes 14 and 1/2 corresponded with 4.3% and 0.7% of all isolates. Antimicrobial resistance genes, including tet(O), erm(B), lnu(B), lsa(E), tet(M), and mef(A/E), were analysed, which were present in 85.8%, 65.2%, 7%, 7%, 6.3%, and 1% of the samples, respectively. Susceptibility testing for 18 antimicrobials revealed high resistance levels, particularly for clindamycin (88.4%), chlortetracycline (89.4%), and sulfadimethoxine (94.4%). Notably, seven significant associations (p < 0.0001) were detected, correlating specific antimicrobial resistance genes to the observed phenotypic resistance. These findings contribute to understanding the S. suis serotype distribution and its antibiotic resistance profiles in Spain, offering valuable insights for veterinary and public health efforts in managing S. suis-associated infections.

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Section: Discussioncontrasting

confidence: 80%

“…The resistance distribution for this antimicrobial mirrored that of the quinolones. Specifically, some of the AMR levels reported worldwide were 1.9% [ 59 ], 2% [ 56 ], 6.2% [ 45 ], 11.3% [ 54 ], and 19.8% [ 55 ]. Hence, it can be assumed that the AMR levels for this antimicrobial tend to be low.…”

Section: Discussionmentioning

confidence: 99%

Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022

Petrocchi Rilo,

Gutiérrez Martín,

Acebes Fernández

et al. 2024

Veterinary Sciences

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“…The most commonly found combination of AMR genes was erm (B) –tet (O) carried by an IME/dIME inserted in SNF2 of an ICE of the Tn 5252 family ( n =41). This high frequency of erm (B) –tet (O) association has been extensively reported in S. suis [12, 16, 17, 45]. In addition to these AMR genes found on nested elements, 72 additional AMR genes were located on ICEs (seven of the vanG family, three of the Tn 916 family and one of the Tn 1549 family).…”

Section: Resultssupporting

confidence: 68%

“…In S. suis , antimicrobial resistance (AMR) is mainly conferred by acquired genes located on mobile genetic elements (MGEs), which are responsible for the dissemination between bacteria sharing the same environment [14–16]. Whole genome sequencing (WGS) combined with comparative genomic analyses was used to study AMR genes and their location on MGEs in S. suis strains isolated from various countries [12, 15, 17, 18]. These studies showed that two categories of MGEs called integrative conjugative elements (ICEs) and integrative mobilizable elements (IMEs) play an essential role in AMR dissemination in S. suis .…”

Section: Introductionmentioning

confidence: 99%

Virulence genes, resistome and mobilome of Streptococcus suis strains isolated in France

Dechêne-Tempier,

de Boisséson,

Lucas

et al. 2024

Microbial Genomics

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Streptococcus suis is a leading cause of infection in pigs, causing extensive economic losses. In addition, it can also infect wild fauna, and can be responsible for severe infections in humans. Increasing antimicrobial resistance (AMR) has been described in S. suis worldwide and most of the AMR genes are carried by mobile genetic elements (MGEs). This contributes to their dissemination by horizontal gene transfer. A collection of 102 strains isolated from humans, pigs and wild boars in France was subjected to whole genome sequencing in order to: (i) study their genetic diversity, (ii) evaluate their content in virulence-associated genes, (iii) decipher the mechanisms responsible for their AMR and their association with MGEs, and (iv) study their ability to acquire extracellular DNA by natural transformation. Analysis by hierarchical clustering on principal components identified a few virulence-associated factors that distinguish invasive CC1 strains from the other strains. A plethora of AMR genes (n=217) was found in the genomes. Apart from the frequently reported erm(B) and tet(O) genes, more recently described AMR genes were identified [vga(F)/sprA, vat(D)]. Modifications in PBPs/MraY and GyrA/ParC were detected in the penicillin- and fluoroquinolone-resistant isolates respectively. New AMR gene–MGE associations were detected. The majority of the strains have the full set of genes required for competence, i.e for the acquisition of extracellular DNA (that could carry AMR genes) by natural transformation. Hence the risk of dissemination of these AMR genes should not be neglected.

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“…When an isolated bacterium demonstrates resistance to optochin, a simple and low-cost test for the presumptive identification of Streptococcus pneumoniae , the primary target of differential diagnosis, should be performed. Although conventionally, S. suis demonstrates a highly favorable and stable sensitivity profile, routine antimicrobial susceptibility testing is essential for monitoring the potential emergence of antimicrobial resistance 2 , 12 .…”

Section: Discussionmentioning

confidence: 99%

Streptococcus suis meningitis: An emerging zoonotic disease in Brazil

Ramos,

Rego,

Oliveira

et al. 2024

Rev. Soc. Bras. Med. Trop.

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Streptococcus suis has been widely reported as a pathogen in animals, especially pigs. In terms of human health implications, it has been characterized as a zoonosis associated with the consumption of pork products and occupational exposure, particularly in Southeast Asian countries. Here, we present a rare case of human S. suis infection in Brazil, diagnosed in an older adult swine farmer, a small rural producer residing in the semi-arid region of Bahia, Brazil.

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Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China

Abstract: S. suis is a serious zoonotic pathogen. In this study, we investigated the epidemiological and molecular characteristics of 96 S. suis isolates from 10 different provinces of China from 2008 to 2019.

Cited by 6 publications

References 64 publications

Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022

Streptococcus suis Research Update: Serotype Prevalence and Antimicrobial Resistance Distribution in Swine Isolates Recovered in Spain from 2020 to 2022

Virulence genes, resistome and mobilome of Streptococcus suis strains isolated in France

Streptococcus suis meningitis: An emerging zoonotic disease in Brazil

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