Antibiotic resistance of microbial strains isolated from Korean acne patients

Abstract

Over several decades, topical and systemic antibiotics have been the mainstay of treatment for acne vulgaris. The widespread and long-term use of antibiotics in the treatment of acne has resulted in the spread of resistant bacterial strains and treatment failure. We aimed to examine the bacteriology of acne vulgaris and to evaluate its susceptibility to the antibiotics widely used for acne in Korea. We examined the species of bacteria aerobically and anaerobically isolated from 100 Korean acne patients. Among the bacteria isolated, Staphylococcus epidermidis (36 patients) was the most common, followed by Propionibacterium acnes (30 patients). Eleven strains of P. acnes (36.7%) and 25 strains of S. epidermidis (69.4%) were resistant to one or other of the antibiotics tested. A higher proportion of P. acnes isolates were resistant to clindamycin (30%) and erythromycin (26.7%), than to any other antibiotics tested (P = 0.0003). Some S. epidermidis isolates were resistant to tetracycline and doxycycline in addition to clindamycin and erythromycin. In the previous studies, few strains of P. acnes were found to be resistant to any of the antibiotics, but this study shows that antibiotic-resistant strains have been increasing in Korea acne patients.

Clinical differences of Helicobacter pylori infection in children

“…51,[56][57][58][59] The prevalence of metronidazole resistance has been even higher. 21,51,[57][58][59][60][61][62] In Poland, the resistance to clarithromycin depends on the region; in children it was between 9% and 26%, in adults from 3% to 27%; the resistance to metronidazole in children was from 16% to 43%, in adults from 27% to 52%. 27 However, it should be noted that in different countries H. pylori antibiotic resistance varies, and depends mainly on the frequency of antibiotics used for treatment of other infections in a given region.…”

Resistance status of antibiotics in Gram-positive bacteria isolated from acne lesions in İstanbul

“…Bununla beraber, dirençli suşların oranı Hırvatistan'da %83, İtalya'da %60 ve Hollanda'da ise %0 olacak şekilde, ülkeler arasında oldukça değişkenlik göstermekteydi 18 . 2011 ile 2013 yılları arasında yapılan bir başka grup çalışmada da antibiyotiklere dirençli P. acnes oranları %0 ile %53,5 arasında değişiyordu [19][20][21][22] . Kore'de bir yıl arayla yapılan iki çalışmada, P. acnes'in çalışılan herhangi bir antibiyotiğe direnç oranı %0 ve %36,7 olacak şekilde çok farklı saptanmıştır.…”

“…Kore'de bir yıl arayla yapılan iki çalışmada, P. acnes'in çalışılan herhangi bir antibiyotiğe direnç oranı %0 ve %36,7 olacak şekilde çok farklı saptanmıştır. Klindamisin ve eritromisine önemli derecede dirençli P. acnes oranı (sırasıyla %30 ve %26,7), çalışılan diğer antibiyotiklerinkinden oldukça yüksekti 19,20 . Schafer ve ark.…”

<b><i>Staphylococcus epidermidis</i></b>: A Potential New Player in the Physiopathology of Acne?

“…Apart from benzoyl peroxide, the use of topical antibacterials such as erythromycin and clindamycin in monotherapy resulted in the development of antibiotic-resistant strains of not only C. acnes but also of S. epidermidis in 4–6 weeks [30, 57, 66]. Systemic antibiotics have been reported to cause only little resistance but can lead to collateral damage in gut microbiota [30, 33, 67].…”