Antibiotic Resistance in Waste Water and Surface Water and Human Health Implications

Manaia, Célia M.; Vaz‐Moreira, Ivone; Nunes, Olga C.

doi:10.1007/698_2011_118

Cited by 20 publications

(21 citation statements)

References 149 publications

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“…The first involves the isolation of bacteria and antibiotic susceptibility testing, using methods and classification criteria originally proposed for clinical bacteria (e.g., European Committee on Antimicrobial Susceptibility Testing, EUCAST or the Clinical and Laboratory Standards Institute, CLSI). The selection of bacteria tolerant to antibiotics supplemented in the culture media has also been used (Watkinson et al 2007;Novo and Manaia 2010;Manaia et al 2011;Novo et al 2013). These methods have provided a good overview of the resistance occurrence in some bacterial groups of human-commensal and environmental bacteria.…”

Section: Methods Harmonization and Data Sharingmentioning

confidence: 99%

Antibiotic resistance in urban aquatic environments: can it be controlled?

Manaia

Macedo

Fatta‐Kassinos

et al. 2015

Appl Microbiol Biotechnol

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175

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Over the last decade, numerous evidences have contributed to establish a link between the natural and human-impacted environments and the growing public health threat that is the antimicrobial resistance. In the environment, in particular in areas subjected to strong anthropogenic pressures, water plays a major role on the transformation and transport of contaminants including antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes. Therefore, the urban water cycle, comprising water abstraction, disinfection, and distribution for human consumption, and the collection, treatment, and delivery of wastewater to the environment, is a particularly interesting loop to track the fate of antibiotic resistance in the environment and to assess the risks of its trans-mission back to humans. In this article, the relevance of different transepts of the urban water cycle on the potential enrichment and spread of antibiotic resistance is reviewed. According to this analysis, some gaps of knowledge, research needs, and control measures are suggested. The critical rationale behind the measures suggested and the desirable involvement of some key action players is also discussed.

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Section: Methods Harmonization and Data Sharingmentioning

confidence: 99%

Antibiotic resistance in urban aquatic environments: can it be controlled?

Manaia

Macedo

Fatta‐Kassinos

et al. 2015

Appl Microbiol Biotechnol

Self Cite

175

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“…In particular old antibiotics such as aminopenicillins, sulfonamides, tetracyclines or erythromycin are nowadays inactive against bacterial groups formerly susceptible to those drugs. The prevalence of resistance to these old antibiotics can reach more that 50% of some bacterial populations discharged in the final effluents of wastewater treatment plants with conventional treatment (Manaia et al, 2012;Rizzo et al, 2013). The time elapsed between the emergence of a new resistance gene in clinical settings and its detection in municipal wastewater is frighteningly short (Szczepanowski et al, 2009).…”

Section: Risks and Precautions Associated With Antibiotic Resistancementioning

confidence: 99%

“…The time elapsed between the emergence of a new resistance gene in clinical settings and its detection in municipal wastewater is frighteningly short (Szczepanowski et al, 2009). For instance, bacteria resistant to last resort antibiotics mainly or exclusively used in hospitals, such as carbapenems resistant Gram-negative bacteria, vancomycin resistant entereococci (VRE), or methicillin resistant Staphylococcus aureus (MRSA) are nowadays detected in municipal wastewater worldwide (Manaia et al, 2012;Rizzo et al, 2013;Baker-Austin et al, 2006;Fluit and Schmitz, 2004;Hernández et al, 1998;Miyahara et al, 2011). The wide contamination of the environment and the food chain with these genetic determinants may represent a public health calamity.…”

Section: Risks and Precautions Associated With Antibiotic Resistancementioning

confidence: 99%

Wastewater reuse in irrigation: A microbiological perspective on implications in soil fertility and human and environmental health

Becerra-Castro

Lopes

Vaz‐Moreira

et al. 2015

Environment International

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396

211

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The reuse of treated wastewater, in particular for irrigation, is an increasingly common practice, encouraged by governments and official entities worldwide. Irrigation with wastewater may have implications at two different levels: alter the physicochemical and microbiological properties of the soil and/or introduce and contribute to the accumulation of chemical and biological contaminants in soil. The first may affect soil productivity and fertility; the second may pose serious risks to the human and environmental health. The sustainable wastewater reuse in agriculture should prevent both types of effects, requiring a holistic and integrated risk assessment. In this article we critically review possible effects of irrigation with treated wastewater, with special emphasis on soil microbiota. The maintenance of a rich and diversified autochthonous soil microbiota and the use of treated wastewater with minimal levels of potential soil contaminants are proposed as sine qua non conditions to achieve a sustainable wastewater reuse for irrigation.

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“…Indeed, the occurrence of sulfonamide residues, including those of SMX, in river water correlated positively with the presence of sulfonamide resistance genetic determinants [10]. Sulfonamide resistance in water habitats can reach values up to 94% [11], being observed in many commensal and pathogenic bacteria, in particular multidrug resistant [12]. Moreover, sulfonamide resistance genes, often associated with mobile genetic elements, have a widespread distribution in the environment [13].…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of sulfamethoxazole and other sulfonamides by Achromobacter denitrificans PR1

Reis

Ricken

et al. 2014

Journal of Hazardous Materials

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170

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This study aimed to isolate and characterize a microbial culture able to degrade sulfonamides. Sulfamethoxazole (SMX)-degrading microorganisms were enriched from activated sludge and wastewater. The resultant mixed culture was composed of four bacterial strains, out of which only Achromobacter denitrificans PR1 could degrade SMX. This sulfonamide was used as sole source of carbon, nitrogen and energy with stoichiometric accumulation of 3-amino-5-methylisoxazole. Strain PR1 was able to remove SMX at a rate of 73.6 ± 9.6 µmolSMX/gcell dry weight h. This rate more than doubled when a supplement of amino acids or the other members of the mixed culture were added. Besides SMX, strain PR1 was able to degrade other sulfonamides with anti-microbial activity. Other environmental Achromobacter spp. could not degrade SMX, suggesting that this property is not broadly distributed in members of this genus. Further studies are needed to shed additional light on the genetics and enzymology of this process.

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Antibiotic Resistance in Waste Water and Surface Water and Human Health Implications

Cited by 20 publications

References 149 publications

Antibiotic resistance in urban aquatic environments: can it be controlled?

Antibiotic resistance in urban aquatic environments: can it be controlled?

Wastewater reuse in irrigation: A microbiological perspective on implications in soil fertility and human and environmental health

Biodegradation of sulfamethoxazole and other sulfonamides by Achromobacter denitrificans PR1

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