Antibiotic Resistance Determinants of Clostridium perfringens

Rood, Julian I.

doi:10.1007/978-1-4615-7087-5_9

Cited by 5 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research in this laboratory has involved the cloning and molecular analysis of antibiotic resistance determinants from the gram-positive pathogen Clostridium perfringens (1,2,4,15,27,30). As part of these studies, an MLS resistance determinant, ermBP, from C. perfringens CP592 was cloned and shown to belong to the ErmB-ErmAM hybridization class (5,29).…”

mentioning

confidence: 99%

Cloning and sequence analysis of ermQ, the predominant macrolide-lincosamide-streptogramin B resistance gene in Clostridium perfringens

Berryman

Lyristis

Rood

1994

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The erythromycin resistance determinant from Clostridium perfringens JIR100 has been cloned, sequenced, and shown to be expressed in Escherichia coli. An open reading frame with sequence similarity to erm genes from other bacteria was identified and designated the ermQ gene. On the basis of comparative sequence analysis, it was concluded that the ermQ gene represented a new Erm hybridization class, designated ErmQ. Genes belonging to the ErmQ class were found to be widespread in C. perfringens, since 30 of 38 macrolide-lincosamide-streptogramin B-resistant C. perfringens strains, from diverse sources, hybridized to an ermQ-specific gene probe. The ermQ gene therefore represents the most common erythromycin resistance determinant in C. perfringens.

show abstract