Antibiotic resistance and adhesion potential of Bacteroides fragilis clinical isolates from Cape Town, South Africa

Determination of Antibiotic Sensitivity of Bacteroid fragilis Isolated from Patients and Healthy Individuals in Imam Reza Center of Medical Teaching and Treatment-Tabriz

“…This kind of resistance against beta-lactam antibiotic plus beta-lactamase inhibitor shows development of another method of resistance. On the other hand, the results obtained in this research showed a good effect of piperacillin plus tazobactam on isolated B. fragilis which is completely in accordance with reports of other researchers (12,14).…”

“…For example resistance against cefoxitin has been reported from different countries (6,14,16) and the highest resistance level against this antibiotic among B. fragilis is in Taiwan (19). This issue has been reported in the results of this research and also in findings of others (6,14,16,19).…”

“…In the present study, results show that the frequency of B. fragilis isolation among diarrheal and non-diarrheal stool samples were significantly meaningful (P value ≤ 0.02), indicating possible role of B. fragilis in producing diarrhea in patients ( Table 2). The involvement of B. fragilis as etiological agents of gastrointestinal disease has been highlighted by several scientists in recent years ( 14 ). There are many reports on antibiotic resistance increase of anaerobic bacteria especially on B. fragilis.…”

“…For example resistance against cefoxitin has been reported from different countries (6,14,16) and the highest resistance level against this antibiotic among B. fragilis is in Taiwan (19). This issue has been reported in the results of this research and also in findings of others (6,14,16,19). The importance of this issue could be understood better when it is considered that these beta-lactam antibiotics even along with beta-lactamase enzyme inhibitors such as amoxicillin in addition to clavulanic acid, also has lost a high percentage of their effectiveness against Bacteroides (12).…”

The prevalence of antibiotic resistance genes in Bacteroides fragilis group strains isolated in different European countries

“…Resistance to metronidazole has been shown to be associated with the presence of the nitroimidazole resistance gene, nimA-G, which may be either located on plasmids or on chromosomes [7e9]. Although the resistance to metronidazole among Bacteroides strains is fairly rare, recent data show an emergence of resistance in the B. fragilis group isolates against metronidazole, especially in South Africa [4,10], but for Europe we found a decline as regards the prevalences of the nim genes [20].…”