Antibiotic residues in honey in the Chinese market and human health risk assessment

Wang, Yuanping; Dong, Xiaolian; Han, Minghui; Yang, Zichen; Wang, Yi; Lü, Qian; Huang, Min; Luo, Baozhang; Wang, Hexing; Chen, Yue; Jiang, Qingwu

doi:10.1016/j.jhazmat.2022.129815

Cited by 22 publications

(14 citation statements)

References 45 publications

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“…No other types of antibiotics were found in the honey samples. Wang et al [30] carried out a study on 20 different antibiotic residues belonging to the group of quinolones, sulfonamides, tetracyclines, and phenicols in 94 honey samples sold in China using the Tandem LC-MS/MS method. It was stated that 79 out of 94 (84 %) samples were contaminated with antibiotics and quinolones were the most frequent antibiotics found in 65 (69.1 %) honey samples.…”

Section: Resultsmentioning

confidence: 99%

Detection of Multiple Antibiotic Residues in Turkish Pine and Blossom Honeys Using LC–MS/MS Method

Gün,

Dursun,

Arıcı

et al. 2024

Chemistry & Biodiversity

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Due to the high demand for honey, beekeepers often feed the bees with antibiotics to protect honeybees against illnesses; determination of veterinary drugs and their residues in bee products especially in honey is gaining importance. In this study, commercially available 15 different brands, a total of 22 honey (14 blossoms and 8 pines) samples obtained from 5 chain supermarkets in city of Bingöl and Diyarbakır, Turkey were analysed for 29 antibiotic residues. These antibiotics belonging to 10 different categories, including tetracyclines, aminoglycosides, macrolides, sulfonamides, fluoroquinolones, benzimidazoles, anthelmintic, amphenicols, quinolines, and oxazolidines. For the qualitative and quantitative determination of the antibiotics, a triple quadrupole liquid chromatography tandem mass spectrometry (LC‐MS/MS) was used. A total of 10 out of 22 honey (8 blossom, 57.14% and 2 pine, 25%) samples were found to be positive for antibiotics. Among the tested antibiotics, tetracycline, dihydrostreptomycin, streptomycin, erythromycin, and sulfadimidine were detected in the honey samples. Dihydrostreptomycin and sulfadimidine were detected in 6 samples, erythromycin was determined in 4 samples, streptomycin was found in 2 samples, and lastly tetracycline was detected only in one sample. Good linearities were also achieved ranging between R2 = 0.987 and 0.999.

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Section: Resultsmentioning

confidence: 99%

Detection of Multiple Antibiotic Residues in Turkish Pine and Blossom Honeys Using LC–MS/MS Method

Gün,

Dursun,

Arıcı

et al. 2024

Chemistry & Biodiversity

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“…Antibiotic residue level in honey has attracted considerable attention (Wang et al. 2022). There are proposed concentrations for sulfonamide screening in honey, and the minimum required performance limit (MRPL) has been set for chloramphenicol (0.3 μg kg −1 in honey) (Zhang et al.…”

Section: Transmission Of Args Mediated By Honeybeesmentioning

confidence: 99%

“…Sulfamethazine and nitroimidazoles were found to transfer from contaminated beeswax to honey (Reybroeck et al 2010;Mitrowska & Antczak 2017). Antibiotic residue level in honey has attracted considerable attention (Wang et al 2022). There are proposed concentrations for sulfonamide screening in honey, and the minimum required performance limit (MRPL) has been set for chloramphenicol (0.3 μg kg −1 in honey) .…”

Section: Other Transmission Routes Of Args Carried By Honeybeementioning

confidence: 99%

The honeybee gut resistome and its role in antibiotic resistance dissemination

Sun

Zhang

et al. 2023

Integr. Zool.

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There is now general concern about widespread antibiotic resistance, and growing evidence indicates that gut microbiota is critical in providing antibiotic resistance. Honeybee is an important pollinator; the incidence of antibiotic resistance genes in honeybee gut causes potential risks to not only its own health but also to public and animal health, for its potential disseminator role, thus receiving more attention from the public. Recent analysis results reveal that the gut of honeybee serves as a reservoir of antibiotic resistance genes, probably due to antibiotics application history in beekeeping and horizontal gene transfer from the highly polluted environment. These antibiotic resistance genes accumulate in the honeybee gut and could be transferred to the pathogen, even having the potential to spread during pollination, tending, social interactions, etc. Newly acquired resistance traits may cause fitness reduction in bacteria whereas facilitating adaptive evolution as well. This review outlines the current knowledge about the resistome in honeybee gut and emphasizes its role in antibiotic resistance dissemination.

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“…The occurrence of uoroquinolones in different bee products has been observed and reported in several studies. 16,17 Because the complete elimination of the use of antibiotics in beekeeping is difficult to achieve, it is necessary to strictly monitor the presence of antibiotic residues in honey and other bee products.…”

Section: Introductionmentioning

confidence: 99%

Sensitive immunoenzyme assay for the detection of antibiotic flumequine in honey

Hendrickson,

Zherdev,

Dzantiev

2024

Anal. Methods

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Antibiotic residues in honey in the Chinese market and human health risk assessment

Cited by 22 publications

References 45 publications

Detection of Multiple Antibiotic Residues in Turkish Pine and Blossom Honeys Using LC–MS/MS Method

Detection of Multiple Antibiotic Residues in Turkish Pine and Blossom Honeys Using LC–MS/MS Method

The honeybee gut resistome and its role in antibiotic resistance dissemination

Sensitive immunoenzyme assay for the detection of antibiotic flumequine in honey

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