Antibiotic prophylaxis post-tonsillectomy: is it of benefit?

Colreavy, Michael; Nanan, D; Benamer, Mohamed H.; Donnelly, M.; Blaney, A.W; O’Dwyer, T. P.; Cafferkey, Mary T.

doi:10.1016/s0165-5876(99)00228-1

Cited by 61 publications

(76 citation statements)

References 15 publications

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“…Although antibiotics were deemed beneficial by some studies in relation to post-adenotonsillectomy morbidity 1,4 , one needs to consider the significant prevalence of adverse effects in the patient population 1,16 and, above all, the issue of bacterial resistance to antibiotics and the cost of treatment. Thus, the routine use of amoxicillin in post-adenotonsillectomy patients remains controversial.…”

Section: Resultsmentioning

confidence: 99%

Avaliação da antibioticoterapia na morbidade pós-adenotonsilectomia: estudo prospectivo randomizado

Guerra

García

Pilan

et al. 2008

Rev. Bras. Otorrinolaringol.

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Tonsi llectomy with or without adenoidectomy still is one of the most commonly performed surgical procedures in the world, mostly in the pediatric population. Aim: to study the impact of amoxicillin for 7 days in post-adenotonsillectomy recovery, comparing results with a control group. Study type: prospective, randomized, controlled study with 120 patients. Patients and Methods: the patients were randomized according to surgery time to receive 7 days of amoxicillin associated with pain killers, or analgesic alone. During the first week of postoperative, we assessed the level of pain, oral intake acceptance, nausea and vomits, fever and return to daily activities. Results: It was only in the fourth postoperative day that the group receiving antibiotic agents showed a statistically significant difference as far as pain is concerned. There was no difference between the two groups for other data analyzed. Conclusion: considering the results from our study and reviewing the literature on the use of antibiotic agents, we agree that there is no improvement in patient recovery after adenotonsillectomy with the use of amoxicillin for 7 days in the postoperative.

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Section: Resultsmentioning

confidence: 99%

Avaliação da antibioticoterapia na morbidade pós-adenotonsilectomia: estudo prospectivo randomizado

Guerra

García

Pilan

et al. 2008

Rev. Bras. Otorrinolaringol.

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“…), the key tissue reaction to the presence of microorganisms is inflammation. 7 After tonsillectomy, with or without adenoidectomy, the colonization of the open tonsillar fossa by the oral bacterial flora may cause severe local inflammatory reaction exacerbating postoperative pain 1 . Pain and discomfort are symptoms of significant magnitude postoperatively, even after therapy with narcotic drugs.…”

Section: Literature Reviewmentioning

confidence: 99%

“…prosthesis). 7,16 The prophylactic use of antimicrobial drugs in surgery is indicated in surgical interventions with high probability of infection of the surgical wound, such as clean-contaminated surgeries or potentially contaminated surgeries, for surgeries in which septic complications represent total loss, such as surgical procedures to implant prosthesis and in immunedepressed patients 17,18 Elevated infection rates without antibiotic therapy and their reduction after its use, in clinical, controlled studies justify prophylaxis under such circumstances. 13 In the case of contaminated and infected surgeries the indication of antibiotic therapy is made for curative and not prophylactic purpose in compliance with standards already established for conventional antibiotic therapy.…”

Section: Prophylaxis With Antibiotic Therapy For Surgerymentioning

confidence: 99%

Antibióticos em tonsilectomias: terapêutico ou profilático? Necessário ou abusivo?

Piltcher

Scarton

2005

Rev. Bras. Otorrinolaringol.

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A adenotonsilectomia é uma das cirurgias mais comumente realizadas na população pediátrica e adulta jovem. A morbidade pós-operatória de tal procedimento cirúrgico é importante incluindo odinofagia, disfagia, otalgia, febre, halitose, perda ponderal e redução da aceitação por via oral. Após a tonsilectomia, com ou sem adenoidectomia, a colonização da loja tonsilar aberta pela flora bacteriana oral causaria uma exacerbação da reação inflamatória local, piorando a dor pós-operatória. A hipótese de que a redução da população bacteriana na ferida cirúrgica aberta possa diminuir a inflamação local, promover o processo cicatricial e acelerar a recuperação pós-operatória determinou inúmeros estudos que abordaram a relação entre o uso perioperatório de antibióticos e a morbidade pós-operatória da adenotonsilectomia. Apesar desses estudos se definirem como avaliadores do uso profilático cirúrgico de antibióticos nessas cirurgias, não houve seguimento das normas de antibioticoprofilaxia cirúrgica internacionalmente aceitas, sendo que a maioria utiliza antibióticos por sete dias pós-operatórios. Através de uma revisão crítica da literatura, os autores discutem os prós e contras do uso de antibiótico nas tonsilectomias ou adenotonsilectomias, assim como a correta definição para sua utilização.

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“…However, these procedures also require constant monitoring and verification of their usability. One example is the ongoing discussion in the literature regarding the justification of intravenous antibiotic therapy in patients undergoing tonsillectomy [1,2,6,8].…”

mentioning

confidence: 99%