Antibiotic prophylaxis in surgery for hip fractures

Hjortrup, A; Sørensen, Carsten; Mejdahl, Steen; M, Horsnaes; Kjersgaard, P

doi:10.3109/17453679009006509

Cited by 16 publications

(4 citation statements)

References 5 publications

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“…We found no significant effect of antibiotic prophylaxis in hip fracture patients and we are in agreement with several randomized [3,7,9,10,11] studies. It is doubtful whether antibiotic prophylaxis should be given to hip fracture patients.…”

Section: Discussionsupporting

confidence: 80%

Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures

Solgaard

Tuxoe

Mafi

et al. 2000

International Orthopaedics

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Of 163 patients with intertrochanteric hip fractures 87 received 2 g dicloxacillin and 240 mg of gentamicin preoperatively, and 76 patients had no antibiotic prophylaxis. Preoperative antibiotic prophylaxis was not shown to have any significant effect on wound infections. However, 16 reversible and 1 irreversible cases of kidney toxicity were found among patients receiving antibiotic prophylaxis, whereas there were only four cases of reversible kidney damage among the patients not receiving antibiotics.Résumé Parmi 163 patients avec des fractures intertrochantériennes, 87 patients avaient reçu en préopéra-toire 2 g Dicloxacilline et 240 mg Gentamicine. 76 patients n'avaient reçu aucune prophylaxie antibiotique. La prophylaxie préopératoire contre les infections n'a montré aucun effet significatif. Cependant dans le groupe avec prophylaxie, 17 affections rénales ont été observées, dont 16 réversibles et 1 irréversible. Parmi les patients n'ayant reçu aucune prophylaxie antibiotique 4 affections rénales réversibles ont été observées.

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Section: Discussionsupporting

confidence: 80%

Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures

Solgaard

Tuxoe

Mafi

et al. 2000

International Orthopaedics

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“…Such terms may be suggestive of the CDC-guidelines, although this could not be confirmed in the text. It has to be stated that terms like superficial and deep infection already existed in the literature prior to the introduction by the CDC, proven by two articles included in this group [72,80]. So overall the authors of 28 studies were contacted by email with a request for additional information regarding the exact definition of infection, and their perception of superficial infection, deep infection and other terms described in their papers.…”

Section: Resultsmentioning

confidence: 99%

Definition of infection after fracture fixation: A systematic review of randomized controlled trials to evaluate current practice

Metsemakers

Kortram²,

Morgenstern

et al. 2018

Injury

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“…The studies which question the use of postoperative doses of antibiotics have many drawbacks. 11,12 Moreover, when operating to treat hip fractures, sometimes the standards of hygiene may slip from those rigorously strived for in joint replacements (like an open fracture or an infected case preceding the surgery for hip fractures). Sometimes, such surgery may be performed without the benefit of laminar flow theatres.…”

Section: Discussionmentioning

confidence: 99%

Timing of antibiotic prophylaxis in surgery for adult hip fracture

Thonse¹,

Sreenivas²,

Sherman³

2004

Ann R Coll Surg Engl

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Background: Antibiotic prophylaxis is widely used in surgery for hip fractures. Methods and Results:In a retrospective study of case notes of 100 patients, frequent inaccuracies in dose administration were observed. This was applicable to both the pre-operative and the postoperative doses. Longer time intervals between the doses, failure to administer the prescribed doses, and failure of proper documentation were observed. Conclusions: Improvement in the awareness of staff and timely administration of prophylactic antibiotic has resulted from this study.

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Antibiotic prophylaxis in surgery for hip fractures

Cited by 16 publications

References 5 publications

Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures

Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures

Definition of infection after fracture fixation: A systematic review of randomized controlled trials to evaluate current practice

Timing of antibiotic prophylaxis in surgery for adult hip fracture

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