Antibiotic prophylaxis in clean head and neck surgery: A prospective randomised controlled trial

Abstract

Prophylactic antibiotics appear to have no benefit in revision, clean head and neck surgery. Further studies in larger populations and other settings are needed. (ClinicalTrials.gov number NCT01980082, clinicaltrials.gov/ct2/show/NCT01980082).

Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis

“…After exclusion of duplicates, we screened 760 references and identified 18 eligible references; from these, nine were excluded as not meeting inclusion criteria or not providing data on the outcome of interest [12,[16][17][18][19][20][21][22][23]. The remaining nine studies presenting quantitative data were included in the meta-analysis [11,[13][14][15][24][25][26][27][28].…”

“…Characteristics of the included studies are presented in Table 1. Four studies were RCTs [14,24,27,28] and five nRCTs [13,15,25,26], published between 2013 and 2021. Two studies were multicentric [11,13], involving 27 and 38 departments of surgery, respectively, while the remaining studies provided data from a single center [13,14,[24][25][26][27][28].…”

“…Four studies were RCTs [14,24,27,28] and five nRCTs [13,15,25,26], published between 2013 and 2021. Two studies were multicentric [11,13], involving 27 and 38 departments of surgery, respectively, while the remaining studies provided data from a single center [13,14,[24][25][26][27][28]. The included studies involved 8710 participants (a range of 53 to 2926 per study) from eight countries (Greece, Korea, India, Israel, Italy, Japan, the US and Sweden) in three continents (Europe, Asia and America).…”

“…The mean age ranged from 43.11 to 60.6 years, while the highest prevalence of male sex was 26.6%. Similar inclusion criteria across studies were clean neck surgery for thyroid [11,14,15,25,28] or thyroid and parathyroid diseases [24,26,27,29]. Five studies included only thyroidectomies, while four also included parathyroidectomies; in one study [27] two parotidectomies were also included (3.7%, one per each group).…”

Prophylactic use of antibiotics as per SIGN 104 guidelines versus routine antibiotic prophylaxis for prevention of surgical site infection in clean and clean contaminated ENT surgical procedures: a comparative study

“…24 On the other hand Shkedy et al did not find prophylactic use of cefazolin to reduce post-operative infection in revision clean head neck surgery. 25 We chose to study the efficacy of SIGN 104 guidelines because we found these quite easy to follow, as these guidelines have clearly spelt out procedure wise, whether to use prophylactic antibiotics or not. Where antibiotic prophylaxis is recommended, the choice of antibiotics and dosage is also spelt out.…”