Antibiotic potentiating action of α-PINENE and borneol against EPEC and ETEC sorotypes

Leite-Sampaio, Nadghia F.; Gondim, Cícera Natália Figueiredo Leite; Souza, Celestina Elba Sobral de; Coutinho, Henrique Douglas Melo

doi:10.1016/j.micpath.2021.105371

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…The antibacterial effect observed against E. coli can be attributed to a synergistic action of the constituents, and not only of the major constituent. In a previous study, when such a constituent was tested as a single compound against the same strain of E. coli , its low activity was observed [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

et al. 2022

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One of the main global problems that affect human health is the development of bacterial resistance to different drugs. As a result, the growing number of multidrug-resistant pathogens has contributed to an increase in resistant infections and represents a public health problem. The present work seeks to investigate the chemical composition and antibacterial activity of the essential oil of Syzygium cumini leaves. To identify its chemical composition, gas chromatography coupled to mass spectrometry was used. The antibacterial activity test was performed with the standard strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 25853 and Staphylococcus aureus ATCC 25923 and multidrug-resistant clinical isolates E. coli 06, P. aeruginosa 24 and S. aureus 10. The minimum inhibitory concentration (MIC) was determined by serial microdilution as well as the verification of the modulating effect of the antibiotic effect. In this test, the oil was used in a subinhibitory concentration. The test reading was performed after 24 h of incubation at 37 °C. The results show that the major chemical constituent is α-pinene (53.21%). The oil showed moderate activity against E. coli ATCC 25922, with the MIC of 512 µg/mL; there was no activity against the other strains. The oil potentiated the effect of antibiotics demonstrating possible synergism when associated with gentamicin, erythromycin and norfloxacin against E. coli 06 and S. aureus 10.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

et al. 2022

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“…D-(+)-camphor is obtained from camphor laurel wood ( Cinnamonum camphora ), while semi-synthetic L-(−)-camphor from fir oil. The terpene alcohols borneol and isoborneol, with a huge number of valuable pharmacological properties [ 4 , 5 , 6 ], have an identical 1,7,7-trimethylbicyclo[2.2.1]heptane backbone.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles

Oreshko

Kovaleva²,

Mordvinova³

et al. 2022

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A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (−)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.

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“…1B ) is a natural bicyclic terpene derivative with antibacterial and antiadhesive properties ( 11 , 12 ). Because of its penetration-promoting effect ( 13 – 15 ), borneol is often used in combination with other antibacterial agents to exert a synergistic antibacterial effect ( 16 – 18 ). Citral and borneol are both oxygenated monoterpenes that can penetrate phospholipid membranes, physically disturbing their structural and functional properties ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activities of Borneol-Citral-Loaded Pickering Emulsions against Pseudomonas aeruginosa and Staphylococcus aureus in Physiologically Relevant Chronic Infection Models

et al. 2022

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There is clearly an urgent need for novel formulations with antimicrobial and antibiofilm activity, but while there are plenty of studies investigating them using simple in vitro systems, there is a lack of studies in which (combinations of) phytochemicals are evaluated in relevant models that closely resemble the in vivo situation. Here, we examined the antibiofilm activity of borneol, citral, and their combination as well as Pickering emulsions (stabilized by solid particles) of these compounds.

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Antibiotic potentiating action of α-PINENE and borneol against EPEC and ETEC sorotypes

Cited by 6 publications

References 22 publications

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

Phytochemical Analysis, Antibacterial Activity and Modulating Effect of Essential Oil from Syzygium cumini (L.) Skeels

Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles

Antibiofilm Activities of Borneol-Citral-Loaded Pickering Emulsions against Pseudomonas aeruginosa and Staphylococcus aureus in Physiologically Relevant Chronic Infection Models

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