Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles

Abstract

A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (−)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.

Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses

“…As one of the reasons of this search is the possibility of the development of resistance against existing drugs, it is not surprising that the researchers consider different classes of organic compounds. Promising results were demonstrated by the derivatives of adamantane 20 , 21 , 1,2,4-triazine [22] , terpenoids 23 , 24 , 25 , 26 , 27 , 28 , 29 .…”