Antibiotic Polymers: α-Aminobenzyl-penicilln (Ampicillin)

Butcher, Brian T.; Stanfield, M. K.; Stewart, Gordon T.; Zemelman, R

doi:10.1080/15421407108082785

Cited by 18 publications

(3 citation statements)

References 6 publications

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“…The strongest support for this comes from the immuno sorbent experiments. Such specificity of the polymer reactions has been suggested previously [10], Thus the low potency of the benzylpenicillin polymers may be explained on a structural basis [1,11].…”

Section: Discussionmentioning

confidence: 73%

Ampicillin Polymers as Elicitors of Passive Cutaneous Anaphylaxis

Ahlstedt¹,

Kristoffersson²,

Svärd³

et al. 1976

Int Arch Allergy Immunol

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The ability of ampicillin polymers to elicit passive cutaneous anaphylaxis (PCA) reactions in guinea pigs was analyzed. Mediating antibodies were raised in rabbits against a crude preparation of 6-aminopenicillanic acid (6-APA). It was found that large ampicillin polymers were potent elicitors, 1,000-fold better than benzylpenicillin polymers. Small polymers in high concentrations did not elicit PCA reactions but inhibited the activity of the larger polymers. This inhibition was more pronounced than that of ampicillin monomer. High molecular weight of ampicillin polymer in the amount of 0.1% in an ampicillin solution manifested its PCA activity. The tendency of ampicillin to polymerize, particularly when kept in solution, makes this observation worth considering. The PCA reactions described were penicilloyl-specific as verified by immunosorbent experiments.

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Section: Discussionmentioning

confidence: 73%

Ampicillin Polymers as Elicitors of Passive Cutaneous Anaphylaxis

Ahlstedt¹,

Kristoffersson²,

Svärd³

et al. 1976

Int Arch Allergy Immunol

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“…20 Interestingly, certain beta-lactams have been reported to self-assemble into polymeric structures. 21 These self-assembling chains polymerize via peptide bond formation, have diminished antimicrobial bioactivity, and may illicit a negative host immune response. 22 Therefore, other techniques to create beta-lactambased polymers are currently being explored.…”

Section: ■ Traditional Antibioticsmentioning

confidence: 99%

“…Beta-lactam antibacterial activity is due to the inhibition of peptidoglycan cross-linking in the bacterial cell wall . Interestingly, certain beta-lactams have been reported to self-assemble into polymeric structures . These self-assembling chains polymerize via peptide bond formation, have diminished antimicrobial bioactivity, and may illicit a negative host immune response .…”

Section: Traditional Antibioticsmentioning

confidence: 99%

Inherently Antimicrobial Biodegradable Polymers in Tissue Engineering

Watson

Tatara

Kontoyiannis

et al. 2016

ACS Biomater. Sci. Eng.

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Many of the strategies currently being explored in the field of tissue engineering involve the combination of cells and degradable engineered scaffolds for the regeneration of biological tissues. However, infection of the wound or the scaffold itself results in failure of healing. Therefore, a new area of development in the field is the synthesis of polymer-based scaffolds that inherently have the ability to resist microbial infection as degradation occurs and new tissue replaces the scaffold. These scaffolds, defined as inherently antimicrobial biodegradable polymers (IABPs), can be classified based on their monomeric components as follows: (1) traditional antimicrobials (such as beta-lactams, fluoroquinolones, glycopeptides, and aminoglycosides), (2) naturally derived compounds (such as extracellular matrix components, chitosan, and antimicrobial peptides), and (3) novel synthetic antimicrobials. After validation of chemical synthesis as well as physicochemical characterization of a newly created IABP, thorough in vitro and in vivo assays must be conducted to ensure antimicrobial efficacy as well as biocompatibility as a tissue-engineered scaffold system. In this review, we will introduce existing IABPs, discuss the current platforms that have been developed for the synthesis of IABPs, and highlight future directions as well as challenges in the field.

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Polymeric drugs

Batz

1977

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Antibiotic Polymers: α-Aminobenzyl-penicilln (Ampicillin)

Cited by 18 publications

References 6 publications

Ampicillin Polymers as Elicitors of Passive Cutaneous Anaphylaxis

Ampicillin Polymers as Elicitors of Passive Cutaneous Anaphylaxis

Inherently Antimicrobial Biodegradable Polymers in Tissue Engineering

Polymeric drugs

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