Antibiotic loading and development of antibacterial capsules by using porous CaCO3 microparticles as starting material

Said, Fayida Ali; Bousserrhıne, Noureddine; Alphonse, Vanessa; Michely, Laurent; Belbekhouche, Sabrina

doi:10.1016/j.ijpharm.2020.119175

Cited by 26 publications

(14 citation statements)

References 63 publications

(68 reference statements)

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“…coli has an obvious descendent trend from NWM to NWM CS -CaCO 3 /PSA. Although chitosan and calcium carbonate have been listed in the literature to have antibacterial activity, in this particular case, their presence in the material structure decreased the TCH activity against the tested bacterial strains.…”

Section: Results and Discussionmentioning

confidence: 90%

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO₃ Patterns with Biomedical Applications

Vasiliu¹,

Zaharia²,

Bazarghideanu³

et al. 2021

Biomacromolecules

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Herein, we report a simple method to obtain hydrophobic surfaces by surface modification with calcium carbonate via diffusion-controlled crystallization using a cheap, versatile, and super-hydrophilic cellulose-based nonwoven material (NWM) as the substrate. To control the CaCO3 crystal growth, the ammonium carbonate diffusion method was applied in the presence of polyanions [poly(acid acrylic), poly(2-acrylamido-2-methylpropanesulfonic acid), and a copolymer which contains 55 mol % 2-acrylamido-2-methylpropanesulfonic acid and 45 mol % acrylic acid] or nonstoichiometric polyelectrolyte complexes with polycations [poly(allylamine hydrochloride) and chitosan] on a pristine NWM and on polycation-treated surfaces. The surface morphology obtained by calcite growth under surface or environmental functional groups’ influence and the hydrophilic/hydrophobic character of the composite materials were followed and compared to that of the starting material. The obtained composite materials become hydrophobic, having a contact angle in the range of 110–135°. The capacity of tetracycline sorption and release by selected modified surfaces were followed and compared to the untreated NWM. Also, the biological properties were evaluated in terms of biocompatibility, antibacterial activity, and antifouling capability.

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Section: Results and Discussionmentioning

confidence: 90%

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO₃ Patterns with Biomedical Applications

Vasiliu¹,

Zaharia²,

Bazarghideanu³

et al. 2021

Biomacromolecules

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“…Ali Said et al [ 49 ] also made a study to target resistant bacteria that live in the intracellular environment. In their study, porous calcium carbonate (CaCO 3 ) microparticles were studied in two aspects.…”

Section: Polymeric Microparticles In Biological Testsmentioning

confidence: 99%

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

Silva

Menezes

Oliveira

et al. 2023

IJMS

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Microparticulate systems such as microparticles, microspheres, microcapsules or any particle in a micrometer scale (usually of 1–1000 µm) are widely used as drug delivery systems, because they offer higher therapeutic and diagnostic performance compared to conventional drug delivery forms. These systems can be manufactured with many raw materials, especially polymers, most of which have been effective in improving the physicochemical properties and biological activities of active compounds. This review will focus on the in vivo and in vitro application in the last decade (2012 to 2022) of different active pharmaceutical ingredients microencapsulated in polymeric or lipid matrices, the main formulation factors (excipients and techniques) and mostly their biological activities, with the aim of introducing and discussing the potential applicability of microparticulate systems in the pharmaceutical field.

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“…The encapsulation of large sensitive macromolecules is possible due to the ability to form and load vaterite at close-to-physiological conditions [124], thereby maintaining the bioactivity of such materials [88]. Vaterite CaCO 3 also proved itself a diverse material as both a stand-alone drug delivery vehicle [131][132][133][134] and as a material for surface coatings [123] for functional use as an antimicrobial carrier, for instance [135,136]. However, there can be an issue with the aggregation of vaterite CaCO 3 crystals, making it difficult to form monodisperse templates without the need of additives, such as polypeptides [137].…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

“…both a stand-alone drug delivery vehicle [131][132][133][134] and as a material for surface coatings [123] for functional use as an antimicrobial carrier, for instance [135,136]. However, there can be an issue with the aggregation of vaterite CaCO3 crystals, making it difficult to form monodisperse templates without the need of additives, such as polypeptides [137].…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Vikulina

Campbell

2021

Nanomaterials

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One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.

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Antibiotic loading and development of antibacterial capsules by using porous CaCO3 microparticles as starting material

Cited by 26 publications

References 63 publications

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO₃ Patterns with Biomedical Applications

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO₃ Patterns with Biomedical Applications

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

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Antibiotic loading and development of antibacterial capsules by using porous CaCO3 microparticles as starting material

Cited by 26 publications

References 63 publications

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO3 Patterns with Biomedical Applications

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO3 Patterns with Biomedical Applications

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

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Product

Resources

About

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO₃ Patterns with Biomedical Applications

Hydrophobic Composites Designed by a Nonwoven Cellulose-Based Material and Polymer/CaCO₃ Patterns with Biomedical Applications