Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention

Álvarez, Gisela Solange; Hélary, Christophe; Mebert, Andrea Mathilde; Wang, Xiaolin; Coradin, Thibaud; Desimone, Martín Federico

doi:10.1039/c4tb00327f

Cited by 157 publications

(108 citation statements)

References 57 publications

(131 reference statements)

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“…In another contribution, silica nanoparticles loaded with drug molecules were formulated with collagen into an NC hydrogel for drug delivery, as described by Desimone et al Higher concentrations of Si NPs resulted in inhomogeneous aggregation of nanoparticles, which perturbed the collagen fibrillary network and thus reduced the elastic properties of the NC hydrogels. Therefore, Si NPs were only able to reinforce the collagen network to a limited extent.…”

Section: Applications Of Nanocomposite Hydrogels In Tissue Engineeringmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Motealleh

Kehr

2016

Adv Healthcare Materials

117

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Nanocomposite (NC) hydrogels, organic-inorganic hybrid materials, are of great interest as artificial three-dimensional (3D) biomaterials for biomedical applications. NC hydrogels are prepared in water by chemically or physically cross-linking organic polymers with nanomaterials (NMs). The incorporation of hard inorganic NMs into the soft organic polymer matrix enhances the physical, chemical, and biological properties of NC hydrogels. Therefore, NC hydrogels are excellent candidates for artificial 3D biomaterials, particularly in tissue engineering applications, where they can mimic the chemical, mechanical, electrical, and biological properties of native tissues. A wide range of functional NMs and synthetic or natural organic polymers have been used to design new NC hydrogels with novel properties and tailored functionalities for biomedical uses. Each of these approaches can improve the development of NC hydrogels and, thus, provide advanced 3D biomaterials for biomedical applications.

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Section: Applications Of Nanocomposite Hydrogels In Tissue Engineeringmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Motealleh

Kehr

2016

Adv Healthcare Materials

117

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“…Additionally, silica NPs loaded with two types of antibiotics were generated for NC hydrogel preparation. The silica NPs/collagen NC hydrogels showed extended antimicrobial activity which was regulated by electrostatic interactions between drug, silica, and collogen …”

Section: Nanocomposite Hydrogels Of Nanomaterials As Biomaterialsmentioning

confidence: 99%

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

2014

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In biotechnology, SAMs and NC hydrogels of functional nanomaterials are of high interest as 2D and 3D cell culture systems, respectively, to mimic natural ECM and to control cell behaviors. Advanced biotechnological approaches often use nanoscale topography together with suitable surface functionalization, as a model of ECM, to control cell behaviors and tissue formation. SAMs of NMs are effective ECM models as 2D surfaces due to their larger nanostructured surface areas which provide higher molecular density by functionalization on a planar substrate than molecular SAMs. Additionally, NC hydrogels, produced by cross-linking of organic polymers with NMs, are excellent candidates as 3D cell culture systems owing to their optical, cell-compatibility and the extraordinary mechanical properties.

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“…In parallel, the incorporation of silica nanoparticles (SiNPs) has been shown to enhance the mechanical properties of hydrogels, [49][50][51][52][53] enhances biological activity of biomaterials 54 and has been widely studied in the field of drug delivery. [55][56][57][58][59][60] SiNPs are particularly interesting candidates due to their low cost, limited cytotoxicity, ease of synthesis, and the versatility of sol-gel chemistry that offers various routes to conjugate biomolecules at the NP surface, while preserving their molecular recognition properties. 61,62 Here we combine self-assembled PA matrices with SiNPs to design novel SiNP-PA composite biomaterials (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

Dems

Freeman

Coradin

et al. 2020

Preprint

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Because the positioning and clustering of biomolecules within the extracellular matrix dictates cell behaviors, the engineering of biomaterials incorporating bioactive epitopes with spatial organization tunable at the nanoscale is of primary importance. Here we used a highly modular composite approach combining peptide amphiphile (PA) nanofibers and silica nanoparticles, which are both easily functionalized with one or several bioactive signals. We show that the surface of silica nanoparticles allows the clustering of RGDS bioactive signals leading to ASSOCIATED CONTENT Supporting Information. Characterization of the synthesized peptides; Characterization of the synthesized PAs; SiNPs characterization; Synthesis and characterization of peptide-conjugated SiNPs; Quantification of surface functionalization -Copper-free Click Chemistry Cy3-Azide; Characterization of the self-assembly of the different PA mixtures by TEM; SEM characterization of the PA layers; 3T3 fibroblasts cultured on non-functionalized SiNP/PA composites; 3T3 fibroblasts cultured on PA-PHSRN and SiNP-PHSRN/PA scaffolds. AUTHOR INFORMATION Corresponding Author

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Antibiotic-loaded silica nanoparticle–collagen composite hydrogels with prolonged antimicrobial activity for wound infection prevention

Cited by 157 publications

References 57 publications

Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications

Multivalent Clustering of Adhesion Ligands in Nanofiber-Nanoparticle Composites

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