Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Motealleh, Andisheh; Kehr, Nermin Seda

doi:10.1002/adhm.201600938

Cited by 118 publications

(69 citation statements)

References 104 publications

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“…However, chitosan‐based hydrogels still face some challenges. Motealleh and Kehr pointed out that the stiffness of hydrogels can influence the morphology of cells [Figure (d)]. A stiffness larger than 20 kPa may cause an elongated and spread morphology of encapsulated cells, but a stiffness less than 5 kPa might result in a circular morphology.…”

Section: Physicochemical Properties Of Chitosan‐based Hydrogels and Tmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including porosity, adhesion, and stiffness. These properties are considered important factors affecting cell proliferation and tissue regeneration. Meanwhile, drug delivery and cell delivery are the two main strategies to improve the therapeutic effects of chitosan‐based hydrogels, but the choices of cells or drugs are quite varied and largely depend on the specificity of the treated tissues. The present review summarizes the physicochemical properties of chitosan‐based hydrogels and their influences on cells, and lists specific ways to promote the tissue regeneration in different systems of the human body. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47235.

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Section: Physicochemical Properties Of Chitosan‐based Hydrogels and Tmentioning

confidence: 99%

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Jiao

Huang

Zhang

2018

J of Applied Polymer Sci

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“…1 Because of the responsiveness and the capacity of abundant water or biological fluid, the smart hydrogels are often described as biological tissues such as cartilage and muscle. Thus, the smart hydrogels show significant potential for various applications, such as smart sensors/ actuators, 5,6 "on/off" switches, [7][8][9] drug delivery vehicles, 10,11 artificial muscles, [12][13][14] tissue engineering scaffolds, [15][16][17] and chemical-separation/bio-separation platforms. 18 The responsiveness and mechanical properties are critical parameters of the smart hydrogels.…”

mentioning

confidence: 99%

Nanocomposite smart hydrogels with improved responsiveness and mechanical properties: A mini review

Liu

Faraj

et al. 2018

J Polym Sci B Polym Phys

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Responsive hydrogels have the ability to change their volume, transparency, or other properties in response to external chemical and/or physical stimuli. The responsiveness properties including responsive rate and degree, as well as mechanical properties such as Young's modulus, toughness, breaking strength, and breaking strain are crucial parameters of the smart hydrogels that determine the scope of hydrogel applications such as soft actuators, artificial muscles, and tissue engineering scaffolds. In this paper, the development of the nanocomposite smart hydrogels, which can achieve both improved responsiveness and mechanical properties, is reviewed. First, the fabrication approaches for building the nanocomposite networks by doping organic or inorganic nanomaterials via crosslinking or blending strategies are introduced. Then, the mechanisms used to improve both responsiveness and mechanical properties of nanocomposite responsive hydrogels are discussed. Finally, the perspectives as well as current challenges of such nanocomposite responsive hydrogels are addressed.

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“…The morphology of fibroblasts is also influenced by stiffness. Stiffness less than 5 kPa can lead to an abnormal morphology (circular) of fibroblasts, whereas they can show a normal morphology (elongated and spread) if the value is more than 20 kPa ( Motealleh and Kehr, 2017 ). However, the effect on enterocytes was unclear.…”

Section: Resultsmentioning

confidence: 99%

Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula

Huang

et al. 2018

iScience

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SummaryThe anti-digestive features given to hydrogels can prolong their action time in gut environment; however, these types of hydrogels have rarely been reported. Inspired by indigestibility of dietary fibers, we introduced an injectable covalent hydrogel through photopolymerization of glycidyl methacrylate-modified xanthan. This newly synthesized hydrogel exhibited a specific concentration-dependent porosity, swelling ratio, and stiffness. The intestinal epithelial cells-6 could grow on the surface of the stiffer hydrogel, and achieved their gut barrier functions. A simulated gut microfluidic chip was manufactured to demonstrate the hydrogel's good performance of anti-digestion compared with the current product, fibrin sealant. Furthermore, calcium ions could induce the swelling-shrinking behavior of the hydrogel, which assisted in removing the hydrogels at the proper time so as to avoid the mismatch of hydrogel degradation and tissue regeneration. Therefore, this hydrogel is expected to be an outstanding gut repair material, especially for closing gastrointestinal fistula.

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Nanocomposite Hydrogels and Their Applications in Tissue Engineering

Cited by 118 publications

References 104 publications

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Hydrogels based on chitosan in tissue regeneration: How do they work? A mini review

Nanocomposite smart hydrogels with improved responsiveness and mechanical properties: A mini review

Bioinspired Anti-digestive Hydrogels Selected by a Simulated Gut Microfluidic Chip for Closing Gastrointestinal Fistula

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