Antibiotic-free nanotherapeutics: Hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing

Nafee, Noha; Youssef, Adel; El‐Gowelli, Hanan M.; Asem, Heba; Kandil, Sherif

doi:10.1016/j.ijpharm.2013.06.067

Cited by 104 publications

(74 citation statements)

References 53 publications

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“…Biological extracts include extracts from plants and animals 92. Seaweed extract‐based hydrogel was reported as an antibacterial wound dressing 93.…”

Section: Biological Extract‐loaded Hydrogelsmentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research. Many advanced antibacterial hydrogels are developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs, and structural diversity. Here, an overview of the structures, performances, mechanisms of action, loading and release behaviors, and applications of various antibacterial hydrogel formulations is provided. Furthermore, the prospects in biomedical research and clinical applications are predicted.

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“…Biological extracts include extracts from plants and animals 92. Seaweed extract‐based hydrogel was reported as an antibacterial wound dressing 93.…”

Section: Biological Extract‐loaded Hydrogelsmentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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“…Thus, PDT may present two synergistic effects: control of microorganisms and accelerate the tissue repair process (Brown, 2012). According to the studies performed by Nafee et al (2013) the PDT promoted healing in less time, better re-epithelialization and keratinization, and better development of collagen fibers compared to the untreated control group. Such findings confirm studies by Brown (2013), which concluded that PDT inactivated a wide variety of microorganisms, accelerated wound healing and prevented clinical infection, especially in patients with chronic wounds.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous streptococcal abscess treated by photodynamic therapy

Sellera¹,

Barbosa²,

Gargano³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Photodynamic therapy has been investigated in different areas of health through experimental conditions. Its action can alter fundamental structures for the survival of microorganisms without any development of microbial resistance. Materials and Methods: Young sheep presenting with abscess in the left forelimb caused by Streptococcus spp. was previously treated with antibiotics. There was no clinical improvement with the treatments, and the bacteria presented sensitivity in vitro. Therefore, Photodynamic therapy associating methylene blue and red laser (660 nm) was used to treat the abscess. Results: After a day of treatment, complete healing was witnessed with no recurrence was observed during the 3-month follow-up period. Conclusion:The scientific results of the antimicrobial effect of PDT proved to be a therapeutic option with great potential for clinical application.

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“…Sixty-three compounds were selected based on the literature of natural compounds. These compounds wound healing effects have already been proven through in vitro and animal studies, namely, taspine, mesaconitine, hypaconitine, songorine, napelline, 12-epinepheline N-oxide, aucubin, cycloastragenol, catechin, epicatechin-3-O-gallate, quercetin-3-O-methyl ether, anthocyanins, silybin, silychristine, silydianine,1,2,3,4,6-Penta-O-galloyl-beta-Dglucose, embelin, framycetin, proanthycyanidin, resveratrol, epi-α-bisabolol, α-bisabolol, α-terpineol, asiaticoside, deoxyelephantopin, β-sitosterol glucoside, β-sitosterol, emodin, kaempferol, quercetin, quercetin-3-O-rutinoside, protocatechuic acid, P-hydroxybenzoic acid, P-coumaric acid, ferulic acid, vanillic acid, mannose-6-phosphate, emblicanin A, acemannan, spinasterol, stigmasterol, isorhamnetin, xyloglucan, gentiopicroside, deoxyshikonin, acetylshikonin, curcumin, linarin, luteolin, 6-hydroxyluteolin, echinacoside, verbascoside, asiatic acid, madecassic acid, madacassoside, fukinolic acid, cimicifugic acid, madecassol, hypericin, hyperin, vincamine, vinpocetine, and crocetin [14,[20][21][22][23][24][25][26][27][28][29][30].…”

Section: Datasetmentioning

confidence: 99%

Energy-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics to Identify Potential Inhibitors for Glycogen Synthase Kinase 3 Beta

Hopper

2018

Asian J Pharm Clin Res

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Objective: Glycogen synthase kinase 3 beta (GSK3β) is one of the main targets for wound healing activity. Our objective is to identify novel inhibitors for GSK3β using in silico approach. Methods:Grid-based molecular docking, energy-based pharmacophore (e-pharmacophore) modeling, and molecular dynamics (MD) studies were performed for phytocompounds with GSK3β and compared with standard drugs using Schrodinger software. Results:The glide scores and the molecular interactions of the phytocompounds were well comparable to the standard drugs. The MD was performed for the target bound to the best scoring ligand, entagenic acid. The pharmacophore features of this docked complex were modeled as e-pharmacophore. The constructed e-pharmacophore model was screened against phytocompounds retrieved from literature to identify the ligands with similar pharmacophore features. Conclusion:The glide scores of fukinolic acid, cimicifugic acid, and linarin were −10.99, −8.28, and −7.25 kcal/mol, respectively. The further 50 nanoseconds MD study determined the stability of GSK3β-linarin complex. Nitrofurazone and sulfathiazole drugs can lead to systemic side effects. Hence, it is concluded that linarin could be a potent wound healing compound against GSK3β.

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Antibiotic-free nanotherapeutics: Hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing

Cited by 104 publications

References 53 publications

Antibacterial Hydrogels

Antibacterial Hydrogels

Cutaneous streptococcal abscess treated by photodynamic therapy

Energy-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics to Identify Potential Inhibitors for Glycogen Synthase Kinase 3 Beta

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