Antibiotic eluting poly(ester urea) films for control of a model cardiac implantable electronic device infection

Nikam, Shantanu P.; Nettleton, Karissa; Everitt, Jeffrey I.; Barton, Hazel A.; Becker, Matthew L.

doi:10.1016/j.actbio.2020.04.025

Cited by 5 publications

(4 citation statements)

References 40 publications

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Section: Morphological and Chemical Characterizations Of The Fiberssupporting

confidence: 64%

“…The stretch around 1000-1300 cm −1 represents the C-O (ester) bond and the C-H (alkyl) bending. All these characteristic signals confirm that we had successfully synthesized the poly(PHE6XX-VAL-10XX) PEU [31]. The X-ray diffraction pattern (Figure 3B) of Ca-TMP can be described as a reflection at 29.45 degrees with FWHM of 0.35 degrees sitting on an amorphous halo, which is the major portion of Ca-TMP that is amorphous with an estimated content of 93 wt%.…”

Section: Morphological and Chemical Characterizations Of The Fiberssupporting

confidence: 62%

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Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Toledo

Anselmi

Dal‐Fabbro

et al. 2023

JFB

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The objective of this research was to create and appraise biodegradable polymer-based nanofibers containing distinct concentrations of calcium trimetaphosphate (Ca-TMP) for periodontal tissue engineering. Poly(ester urea) (PEU) (5% w/v) solutions containing Ca-TMP (15%, 30%, 45% w/w) were electrospun into fibrous scaffolds. The fibers were evaluated using SEM, EDS, TGA, FTIR, XRD, and mechanical tests. Degradation rate, swelling ratio, and calcium release were also evaluated. Cell/Ca-TMP and cell/scaffold interaction were assessed using stem cells from human exfoliated deciduous teeth (SHEDs) for cell viability, adhesion, and alkaline phosphatase (ALP) activity. Analysis of variance (ANOVA) and post-hoc tests were used (α = 0.05). The PEU and PEU/Ca-TMP-based membranes presented fiber diameters at 469 nm and 414–672 nm, respectively. Chemical characterization attested to the Ca-TMP incorporation into the fibers. Adding Ca-TMP led to higher degradation stability and lower dimensional variation than the pure PEU fibers; however, similar mechanical characteristics were observed. Minimal calcium was released after 21 days of incubation in a lipase-enriched solution. Ca-TMP extracts enhanced cell viability and ALP activity, although no differences were found between the scaffold groups. Overall, Ca-TMP was effectively incorporated into the PEU fibers without compromising the morphological properties but did not promote significant cell function.

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Section: Morphological and Chemical Characterizations Of The Fiberssupporting

confidence: 64%

Section: Morphological and Chemical Characterizations Of The Fiberssupporting

confidence: 62%

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Toledo

Anselmi

Dal‐Fabbro

et al. 2023

JFB

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“…Trp-PEUs are novel polymers synthesized from tryptophan (Trp), diols, and hexamethylene diisocyanate (HDI), and the chemical structure of Trp-PEUs has great flexibility . Trp, an essential amino acid, regulates immune response and wound healing. , What’s more, Trp could inhibit the formation of biofilms by disrupting interactions and adherence between bacteria. − The polymers can be degraded, and the byproducts (amino acid metabolites, diacids, and carbon dioxide) are readily absorbed and excreted by the body, thus, they possess very limited inflammatory responses . The strong hydrogen bonding in polymers allows the even distribution of drugs in the material .…”

Section: Introductionmentioning

confidence: 99%

“…45−47 The polymers can be degraded, and the byproducts (amino acid metabolites, diacids, and carbon dioxide) are readily absorbed and excreted by the body, thus, they possess very limited inflammatory responses. 48 The strong hydrogen bonding in polymers allows the even distribution of drugs in the material. 49 Polycaprolactone (PCL) has often been utilized in electrospinning with other polymers owing to its good biocompatibility and stability in processing and storage.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide-Releasing Tryptophan-Based Poly(ester urea)s Electrospun Composite Nanofiber Mats with Antibacterial and Antibiofilm Activities for Infected Wound Healing

Qiu

Wang

et al. 2022

ACS Appl. Mater. Interfaces

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Bacterial biofilms on wounds can lead to ongoing inflammation and delayed reepithelialization, which brings a heavy burden to the medical systems. Nitric oxide based treatment has attracted attention because it is a promising strategy to eliminate biofilms and heal infected wounds. Herein, a series of tryptophan-based poly(ester urea)s with good biodegradation and biocompatibility were developed for the preparation of composite mats by electrospinning. Furthermore, the mats were grafted with a nitric oxide donor (nitrosoglutathione, GSNO) to provide one type of NO loading cargo. The mats were found to have a prolonged NO release profile for 408 h with a maximum release of 1.0 μmol/L, which had a significant effect on killing bacteria and destructing biofilms. The designed mats were demonstrated to promote the growth of cells, regulate inflammatory factors, and significantly improve collagen deposition in the wound, eventually accelerating wound-size reduction. Thus, the studies presented herein provide insights into the production of NO-releasing wound dressings and support the application of full-thickness wound healing.

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Intelligent biomaterials for cardiovascular applications

Tetali,

Fricker,

van Domburg

et al. 2023

Current Opinion in Biomedical Engineering

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Antibiotic eluting poly(ester urea) films for control of a model cardiac implantable electronic device infection

Cited by 5 publications

References 40 publications

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Calcium Trimetaphosphate-Loaded Electrospun Poly(Ester Urea) Nanofibers for Periodontal Tissue Engineering

Nitric Oxide-Releasing Tryptophan-Based Poly(ester urea)s Electrospun Composite Nanofiber Mats with Antibacterial and Antibiofilm Activities for Infected Wound Healing

Intelligent biomaterials for cardiovascular applications

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