Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes

Kacerovský, Marian; Romero, Roberto; Štěpán, Martin; Stráník, Jaroslav; Malý, Jan; Plíšková, Lenka; Bolehovská, Radka; Palička, Vladimír; Žemličková, Helena; Hornychová, Helena; Špaček, Jiří; Jacobsson, Bo; Pacora, Percy; Musilová, Ivana

doi:10.1016/j.ajog.2020.01.043

Cited by 58 publications

(35 citation statements)

References 143 publications

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“…Recently, Kacerovsky and colleagues 18 found that treatment with clarithromycin was associated with attenuation of the intensity of the intraamniotic inflammatory response, in a subset of pregnancies with preterm prelabor rupture of the membranes (PPROM) with sterile intraamniotic inflammation, by assessing the concentrations of interelukin-6 in amniotic fluid before and after antibiotic treatment. Thus, a better understanding of the underlying inflammatory processes linking maternal fever and adverse neonatal outcomes is needed in order to tailor the correct beneficial intervention.…”

Section: Results -In the Context Of What Is Knownmentioning

confidence: 99%

The impact of peak and duration of maternal intrapartum fever on perinatal outcomes

Hochler

Lipschuetz

Guedalia

et al. 2021

American Journal of Obstetrics & Gynecology MFM

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Section: Results -In the Context Of What Is Knownmentioning

confidence: 99%

The impact of peak and duration of maternal intrapartum fever on perinatal outcomes

Hochler

Lipschuetz

Guedalia

et al. 2021

American Journal of Obstetrics & Gynecology MFM

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“…A recent study reported that intravenous administration of select antibiotics, either in combination [20, 39, 40] or as monotherapy [41], may reduce the intensity of intra-amniotic inflammation and even resolve both forms of intra-amniotic inflammation in women with spontaneous preterm labor [40], PPROM [39, 41], and cervical insufficiency with prolapsed fetal membranes [20]. Oh et al [20] reported treatment success (resolution of intra-amniotic inflammation or delivery ≥34 weeks) in 60% of women with cervical insufficiency with intra-amniotic inflammation treated with ceftriaxone, clarithromycin, and metronidazole.…”

Section: Discussionmentioning

confidence: 99%

Intra-Amniotic Infection and Sterile Intra-Amniotic Inflammation in Cervical Insufficiency with Prolapsed Fetal Membranes: Clinical Implications

et al. 2020

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Introduction: The aim of this study was to identify the rates of 2 phenotypes of intra-amniotic inflammation: intra-amniotic infection (with microbial invasion of the amniotic cavity [MIAC]) and sterile intra-amniotic inflammation (without MIAC), and their outcomes, among women with cervical insufficiency with prolapsed fetal membranes. Methods of Study: This is a retrospective study of women admitted to the Department of Obstetrics and Gynecology, University Hospital Hradec Kralove between January 2014 and May 2020. Transabdominal amniocentesis to evaluate intra-amniotic inflammation (amniotic fluid interleukin-6) and MIAC (culturing and molecular biology methods) was performed as part of standard clinical management. Results: In total, 37 women with cervical insufficiency and prolapsed fetal membranes were included; 11% (4/37) and 43% (16/37) of them had intra-amniotic infection and sterile intra-amniotic inflammation, respectively. In women with intra-amniotic infection and sterile intra-amniotic inflammation, we noted shorter intervals between admission and delivery (both p < 0.0001), and lower gestational age at delivery (p < 0.0001 and p = 0.004) and percentiles of birth/abortion weight (p = 0.03 and p = 0.009, respectively) than in those without intra-amniotic inflammation. Conclusions: Both phenotypes of intra-amniotic inflammation, with sterile intra-amniotic inflammation being more frequent, are associated with worse outcomes in pregnancies with cervical insufficiency with prolapsed fetal membranes.

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“…Therefore, the risks of prematurity and intra-amniotic infection/inflammation must be balanced. Antibiotic treatment can reduce the rate of intra-amniotic infection/inflammation, as well as funisitis in a subset of patients with spontaneous preterm delivery with intact membranes [342], cervical insufficiency [343], short cervix [344], and preterm PROM [345][346][347].…”

Section: Strategies For the Management Of Firsmentioning

confidence: 99%

The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications

Jung

Romero

Yeo

et al. 2020

Seminars in Fetal and Neonatal Medicine

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128

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Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes

Cited by 58 publications

References 143 publications

The impact of peak and duration of maternal intrapartum fever on perinatal outcomes

The impact of peak and duration of maternal intrapartum fever on perinatal outcomes

Intra-Amniotic Infection and Sterile Intra-Amniotic Inflammation in Cervical Insufficiency with Prolapsed Fetal Membranes: Clinical Implications

The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications

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