Antibiofilm properties of model composites containing quaternary ammonium methacrylates after surface texture modification

Rego, Guilherme Ferreira; Vidal, Marina Lermen; Viana, Gil Mendes; Cabral, Lúcio Mendes; Schneider, Luís Felipe Jochims; Portela, Maristela Barbosa; Cavalcante, Larissa Maria

doi:10.1016/j.dental.2017.07.010

Cited by 20 publications

(14 citation statements)

References 43 publications

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“…Diverse research with different additives has been carried out to develop effective antibacterial composites. Numerous experiments have focused on resins containing polymerizable antibacterial additives, such as quaternary ammonium dimethacrylate (QADM) [ 25 ], 12-methacryloyloxydodecylpyridinium bromide (MDPB) [ 26 ], dimethylaminohexadecyl methacrylate (DMAHDM) [ 27 ], dimethyl-hexadecyl-methacryloxyethyl-ammonium iodide (DHMAI) [ 28 ], or dimethylaminododecyl and dimethylaminohexadecyl methacrylates [ 29 ]. Other organic materials including quaternary ammonium polyethylenimine (PEI) nanoparticles [ 30 ], chlorhexidine [ 31 , 32 ], triclosan [ 33 ], chitosan [ 34 ], and benzalkonium chloride and acrylic acid [ 35 ] were also tested with varying degrees of success.…”

Section: Introductionmentioning

confidence: 99%

Properties of Experimental Dental Composites Containing Antibacterial Silver-Releasing Filler

Stencel¹,

Kasperski

Pakieła

et al. 2018

Materials

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Secondary caries is one of the important issues related to using dental composite restorations. Effective prevention of cariogenic bacteria survival may reduce this problem. The aim of this study was to evaluate the antibacterial activity and physical properties of composite materials with silver sodium hydrogen zirconium phosphate (SSHZP). The antibacterial filler was introduced at concentrations of 1%, 4%, 7%, 10%, 13%, and 16% (w/w) into model composite material consisting of methacrylate monomers and silanized glass and silica fillers. The in vitro reduction in the number of viable cariogenic bacteria Streptococcus mutans ATCC 33535 colonies, Vickers microhardness, compressive strength, diametral tensile strength, flexural strength, flexural modulus, sorption, solubility, degree of conversion, and color stability were investigated. An increase in antimicrobial filler concentration resulted in a statistically significant reduction in bacteria. There were no statistically significant differences caused by the introduction of the filler in compressive strength, diametral tensile strength, flexural modulus, and solubility. Statistically significant changes in degree of conversion, flexural strength, hardness (decrease), solubility (increase), and in color were registered. A favorable combination of antibacterial properties and other properties was achieved at SSHZP concentrations from 4% to 13%. These composites exhibited properties similar to the control material and enhanced in vitro antimicrobial efficiency.

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Section: Introductionmentioning

confidence: 99%

Properties of Experimental Dental Composites Containing Antibacterial Silver-Releasing Filler

Stencel¹,

Kasperski

Pakieła

et al. 2018

Materials

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“…3 The researches has focused on the addition of this property to the restorative materials since the main reasons for the failure in composite resin restoration are the development of secondary caries due to the formation of biofilms in the gaps of the restoration margins. 19,20,21 Thus, all new material introduced should seek to evaluate the presence of such antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Thiourethane-functionalized fillers: biological properties and degradation resistance

et al. 2021

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This study determined the effect of thiourethanefunctionalized fillers (TU) on the antimicrobial properties, cytotoxicity, degree of conversion (DC), water sorption (Wsp) and solubility (Wsl) of experimental composites. TU-modified fillers were added at different ratios in experimental composites: 0 (Control-TU0), 25% (TU25), 50% (TU50), 75% (TU75) and 100wt% (TU100). The antimicrobial properties were detected through the exhaustion test and counting of Streptococus mutans colonies for biofilm formation. Cytotoxicity to human gingival fibroblasts was evaluated in three different parameters: XTT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide), NRU (Neutral Red Uptake assay) and CVDE (Crystal Violet Dye Exclusion test)) at the same cells. ELISA was used to measure the IL-6 and b-FGF biomarkers. DC was determined by Fourier-transformed infrared spectroscopy, while Wsp and Wsl by mass variations. Inhibitory capacity of biofilm formation was not observed for any material. All groups presented at least 70% of cell survival within the observed periods (24h and 7 days). Positive control (toxic) had high IL-6 values and low b-FGF values. No significant variations in DC, Wsp, and Wsl were observed among the experimental groups. The use of thiourethane did not present antimicrobial and cytotoxic activity and the tested materials presented equivalent properties to those conventionally used in dentistry.

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“…The most common strategy is to load osseointegration coating and then graft antibacterial agents on the modified surface. For instance, dimethylaminododecyl methacrylate (DMADDM) is a new antibacterial agent whose amino group and long alkyl chain can destroy the bacterial membrane, thus exerting a strong inhibitory effect to bacteria and fungi, including drug-resistant strains ( Wang et al, 2017b ; Cheng et al, 2017 ; Rego et al, 2017 ). To endow a HA modified surface with antibacterial property, DMADDM was introduced with the aid of polydopamine (PDA) ( Zhou et al, 2020 ).…”

Section: Prevention Of Aseptic Implant Looseningmentioning

confidence: 99%

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

et al. 2021

Front. Bioeng. Biotechnol.

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Titanium and its alloys are dominant material for orthopedic/dental implants due to their stable chemical properties and good biocompatibility. However, aseptic loosening and peri-implant infection remain problems that may lead to implant removal eventually. The ideal orthopedic implant should possess both osteogenic and antibacterial properties and do proper assistance to in situ inflammatory cells for anti-microbe and tissue repair. Recent advances in surface modification have provided various strategies to procure the harmonious relationship between implant and its microenvironment. In this review, we provide an overview of the latest strategies to endow titanium implants with bio-function and anti-infection properties. We state the methods they use to preparing these efficient surfaces and offer further insight into the interaction between these devices and the local biological environment. Finally, we discuss the unmet needs and current challenges in the development of ideal materials for bone implantation.

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Antibiofilm properties of model composites containing quaternary ammonium methacrylates after surface texture modification

Cited by 20 publications

References 43 publications

Properties of Experimental Dental Composites Containing Antibacterial Silver-Releasing Filler

Properties of Experimental Dental Composites Containing Antibacterial Silver-Releasing Filler

Thiourethane-functionalized fillers: biological properties and degradation resistance

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

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