Antibiofilm efficacy of silver nanoparticles as a vehicle for calcium hydroxide medicament against Enterococcus faecalis

Afkhami, Farzaneh; Pourhashemi, Seyyed Jalal; Sadegh, Mona; Salehi, Yasaman; Fard, Mohammad Javad Kharrazi

doi:10.1016/j.jdent.2015.08.012

Cited by 86 publications

(85 citation statements)

References 32 publications

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“…Moreover, AgNPs have a strong anti-biofilm potential [162,166,167,168,169,170,171,172,173,174,175,176,177,178,179]. Therefore, these are potentially very attractive for surface protection of orthopaedic implants since PJI is biofilm driven in the majority of clinical cases.…”

Section: Why Silver Nanoparticle Technologies On the Implant Surfamentioning

confidence: 99%

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

et al. 2016

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Prosthetic joint infection (PJI) is a feared complication of total joint arthroplasty associated with increased morbidity and mortality. There is a growing body of evidence that bacterial colonization and biofilm formation are critical pathogenic events in PJI. Thus, the choice of biomaterials for implanted prostheses and their surface modifications may significantly influence the development of PJI. Currently, silver nanoparticle (AgNP) technology is receiving much interest in the field of orthopaedics for its antimicrobial properties and a strong anti-biofilm potential. The great advantage of AgNP surface modification is a minimal release of active substances into the surrounding tissue and a long period of effectiveness. As a result, a controlled release of AgNPs could ensure antibacterial protection throughout the life of the implant. Moreover, the antibacterial effect of AgNPs may be strengthened in combination with conventional antibiotics and other antimicrobial agents. Here, our main attention is devoted to general guidelines for the design of antibacterial biomaterials protected by AgNPs, its benefits, side effects and future perspectives in PJI prevention.

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Section: Why Silver Nanoparticle Technologies On the Implant Surfamentioning

confidence: 99%

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

et al. 2016

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“…With a focus on their antimicrobial effects, they have been incorporated into bonding agents and restorative materials to prevent biofilm formation and reduce caries (Durner et al 2011, Garcia-Contreras et al 2011, Cheng et al 2012, orthodontic adhesives (Ahn et al 2009, Degrazia et al 2016) and into implant materials (Sheikh et al 2010, Allaker & Memarzadeh 2014. Silver nanoparticles have been tested as endodontic irrigants and intracanal medicaments (Wu et al 2014, Abbaszadegan et al 2015, added to calcium hydroxide as a vehicle (Javidi et al 2014, Afkhami et al 2015, incorporated into endodontic filling materials (Mohamed Hamouda 2012, Correa et al 2015 and calcium silicate cements (Bahador et al 2015, Vazquez-Garcia et al 2016, and have shown lower levels of cytotoxicity (Gomes-Filho et al 2010, Takamiya et al 2016. Silver nanoparticles have been tested as endodontic irrigants and intracanal medicaments (Wu et al 2014, Abbaszadegan et al 2015, added to calcium hydroxide as a vehicle (Javidi et al 2014, Afkhami et al 2015, incorporated into endodontic filling materials (Mohamed Hamouda 2012, Correa et al 2015 and calcium silicate cements (Bahador et al 2015, Vazquez-Garcia et al 2016, and have shown lower levels of cytotoxicity (Gomes-Filho et al 2010, Takamiya et al 2016.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial properties of silver nanoparticles as a root canal irrigant against Enterococcus faecalis biofilm and infected dentinal tubules

et al. 2018

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“…Mozayeni et al prepared a 50 ppm nanosilver solution in a 1 g methylcellulose carrier gel, but found that it was less effective against C. albicans (when compared to calcium hydroxide and CHX) . Afkhami et al later prepared a 100 ppm silver nanoparticle (size 20 nm) mixed with an equal proportion of calcium hydroxide . This study demonstrated this formulation as having the most significant antimicrobial activity when compared to calcium hydroxide and CHX alone, or in combination.…”

Section: Endodontic Materialsmentioning

confidence: 86%

Oroactive dental biomaterials and their use in endodontic therapy

et al. 2019

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Dental biomaterials have revolutionized modern therapies. Untreated dental caries remains the major etiological factor for endodontic treatment, and together with a decreasing rate of tooth loss escalates the importance of continuously improving the materials used for endodontic therapies. Endodontic biomaterials are used for vital pulp therapies, irrigation, intracanal medicaments, obturation and regenerative procedures. These materials offer several functions including: antimicrobial activity, mechanical reinforcement, aesthetics, and therapeutic effects. Vital pulp therapies have seen an improvement in clinical results with an incremental approach to build on the strengths of past materials such as calcium hydroxide and calcium silicates. While sodium hypochlorite remains the gold standard for canal irrigation, numerous nanoparticle formulations have been developed to promote sustained antimicrobial action. Gutta‐percha based bulk fillers remain the most common materials for root filling. However, while multiple studies focus on the development of novel formulations containing drugs, glass derivatives or ionic‐, polymeric‐, or drug‐ loaded nanoparticles, a lack of reliable and long‐term clinical evidence obligates further study as experienced clinicians prefer to use what has worked for decades. This review delves in to the biochemistry of the materials to scrutinize their shortcomings, and where opportunity lies to further enhance their efficacy in endodontic practice. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:201–212, 2020.

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Antibiofilm efficacy of silver nanoparticles as a vehicle for calcium hydroxide medicament against Enterococcus faecalis

Cited by 86 publications

References 32 publications

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

Antibacterial properties of silver nanoparticles as a root canal irrigant against Enterococcus faecalis biofilm and infected dentinal tubules

Oroactive dental biomaterials and their use in endodontic therapy

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