Antibacterial therapy improves the effectiveness of prostate cancer detection using prostate-specific antigen in patients with asymptomatic prostatitis

Abstract

Using the changes in PSA-related parameters after antibacterial therapy DeltaPSA, DeltaPSAD, and Deltaf/t PSA improve the PC detection rate and decrease unnecessary prostate biopsies in patients with asymptomatic prostatitis.

Prostate biopsy findings in Indian men: A hospital-based study

“…The use of antibiotics has been shown to reduce PSA values in Chinese men and has the potential to reduce unnecessary biopsies in some men with elevated PSA. [12] Another approach has been to examine prostatic secretions following a prostatic massage and treating those with increased leukocyte count. [13] Thirty percent of Japanese men with more than 10 wbc in the prostatic massage secretion showed reduction in PSA after a course antibiotics.…”

Do antibiotics decrease prostate-specific antigen levels and reduce the need for prostate biopsy in type IV prostatitis? A systematic literature review

“…Most cohort studies were rated 'Good Quality'; 9-15 two were rated 'Fair Quality'. 3, 17 The two randomized controlled trials were rated as 'Good Quality' 16 and 'Fair Quality'. 18 …”

Impacts of Antibiotic and Anti-Inflammatory Therapy on Serum Prostate Specific Antigen in Asymptomatic Men: Our Experience

“…L'utilizzo della terapia medica antibiotica è una procedura comune per rivalutare successivamente l'andamento del PSA e decidere dell'iter terapeutico da seguire o se completare la diagnosi attraverso una biopsia prostatica. (12) Negli ultimi anni si è moltiplicato il numero di studi che hanno valutato l'effetto sul PSA della terapia antibiotica somministrata allo scopo di trattare la flogosi subclinica. Karazanashvili ha evidenziato come i dosaggi di PSA pre-e post-terapia antibiotica vadano ad aumentare l'accuratezza diagnostica del CaP nei pazienti affetti da prostatiti croniche con PSA compreso tra 4 e 10 ng/ml.…”