Prostate biopsy findings in Indian men: A hospital-based study

Sinha, Shandip Kumar; Siriguri, SR; Kanakmedala, SK; Bikkasani, Krishna

doi:10.4103/0019-509x.82879

Cited by 13 publications

(12 citation statements)

References 8 publications

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“…Bikkasani K et al found 20.7% cases with Gleason score of 8-10 in their study. 12 Similarly, Gleason score of 7 was seen in 51.6% and 15% cases respectively in studies done by Jaypradeep DP et al and Carter HB et al 2,17 The reason for high Gleason score in our study could be due to the late presentation of the disease. The rate of change in PSA appears to be greater in men with prostate carcinoma compared with men without disease.…”

Section: Discussionsupporting

confidence: 69%

“…1 Similarly other studies also showed that PSA level is usually < 20 ng/ ml in case of benign conditions like BPH. 12,13 Prostatic intraepithelial neoplasia was seen in 5.9 % cases in our study and all the cases were HGPIN with PSA level <10ng/ml. The studies done in two different parts of India showed similar finding (1.8% cases of PIN in each study) and the PSA level was <10 ng/ml.…”

Section: Discussionsupporting

confidence: 45%

“…Similar finding was seen in several other studies. 10,12,15 In a study done by Sridevi N et al, all the cases of carcinoma prostate showed significant elevation of PSA > 20 ng/ml. 16 All the cases of carcinoma prostate were adeno carcinoma.…”

Section: Discussionmentioning

confidence: 96%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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Background: Prostate specific antigen is a tumor marker though is expressed by both normal and neoplastic prostate tissue. The absolute value of Prostate specific antigen is useful for determining the extent of prostate cancer and its treatment. Prostate specific antigen also increases in cases like Benign Prostatic Hyperplasia and prostatitis. The availability of Prostate specific antigen as a marker has encouraged its use to diagnose both cancer and cancer recurrences. Materials and methods: This is a cross sectional study conducted in a tertiary hospital over a period of two years. Cases of prostatic disease undergoing surgery during the study period were taken. Prostate specific antigen level of all these cases were correlated with clinical and histopathological findings. Results: A total of 51 cases of prostatic disease underwent surgery during the study period with the mean age of 66.57 ± 10.68 years. On histopathological examination, 70.6% had benign prostatic hyperplasia and 17.6% had prostatic adenocarcinoma. Prostate specific antigen level was <4 ng/ml in 45.1% cases and >20.1ng/ml in 15.7%. In case of carcinoma prostate, 88.9% had prostate specific antigen level > 20.1ng/ml and 11.1% had prostate specific antigen level in a range of 10.1- 20 ng/ml. In case of chronic prostatitis, 66.7% had prostate specific antigen level in a range of 4.1-10 ng/ml. However, in case of high grade prostatic intraepithelial neoplasia (HGPIN), 66.7% had PSA level <4 ng/ml. Conclusions: Strong correlation of prostate specific antigen levels of > 20.1 ng/ml with carcinoma prostate was seen.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 45%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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“…19 In current study we detect prostate pathology in 112 cases aged between 34 -81 years with mean age of 58+3.4 years, these findings were also observed by other workers. 19,20 Confirming the documented data we observed hyperplasia in 99 (82.1%) cases and among them 6.3% cases were with prostatitis, the hyperplasia was common in 61-70 years age group. 9,19 We histologically diagnose 4.4% cases of adenocarcinoma from a total of 112 cases, the reported data incidence is 3.1%, 4.8% and 6.9% in different studies.…”

Section: Discussionsupporting

confidence: 86%

Histopathological evaluation of clinically diagnosed prostatic lesions.

Yousfani

Memon

Suria³

et al. 2020

TPMJ

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Objectives: To correlate the clinically diagnosed prostatic lesion with histopathological evaluation, Gleason scoring andserum prostate specific antigen (PSA) levels in a tertiary care centre. Study Design: Observational Study. Setting: The current study was conducted in multiple centers of Sindh like Department of Surgery Unit-III, Peoples University of Medical and Health Sciences, Nawabshah CMCH Larkana, Jinnah Sindh Medical University and Al-Tibri Medical College and Hospital Karachi. Period: January 2018 to December 2019. Material & Methods: on 112 consecutive cases of clinically diagnosed prostatic disease, all the relevant demographic and clinical details including digital rectal examination (DRE) findings and serum PSA levels were recorded on a proforma designed for the study. PSA values of all these cases were recorded before the surgical procedure. The tissue sample of prostate was collected after surgery and histologically analysed for the confirmation of diagnosis and the Gleason scoring was made. All the results obtained were statistically analysed and tabulated. Results: The age of patients ranged 34-81 years, with mean age of 58+3.4 years. The adenocarcinoma was detected in 05 cases, hyperplasia in 92 cases and hyperplasia with prostatitis in 07 cases. The carcinoma was clinically diagnosed in 17 cases but after histological evaluation, the carcinoma was confirmed in 03 cases and 02 cases of cancer were confirmed among clinically diagnosed cases of hyperplasia. Majority of cases of hyperplasia were having the PSA level < 4ng/ml No any case of adenocarcinoma have PSA level below 4ng/ml, and majority of the cases of denocarcinoma were having PSA level above 20ng/ml. majority of malignant lesions were having PSA level above 20ng/ml and the Gleason score above 6. No any case of malignancy was detected in those patients having PSA level below 4ng/ml. Conclusion: The histopathological evaluation with serum PSA levels is necessary in all cases of prostatic disease to rule out the possibility of malignant pathology.

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“…Figure 2 shows an immunostaining of carcinogenic PAH-DNA adducts in the peripheral zone of cancer-free prostates from the U.K. and India stained with antiserum specific for a family of carcinogenic PAHs bound to DNA, and semi-quantified by the Automated Cellular Imaging System (ACIS) [ 83 ]. The prostate tissues from India were obtained at a time (2008–2010) when radical retropubic prostatectomy was a rare procedure in this region [ 84 ]. While Figure 2B shows a marked interindividual variation in adduct levels, there is a relatively similar range of PAH-DNA adduct levels in the prostates from both groups.…”

Section: Prostate Cancer and Carcinogenic Pah Exposurementioning

confidence: 99%

Carcinogens and DNA damage

Barnes

Zubair

John

et al. 2018

Biochemical Society Transactions

232

126

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Humans are variously and continuously exposed to a wide range of different DNA-damaging agents, some of which are classed as carcinogens. DNA damage can arise from exposure to exogenous agents, but damage from endogenous processes is probably far more prevalent. That said, epidemiological studies of migrant populations from regions of low cancer risk to high cancer risk countries point to a role for environmental and/or lifestyle factors playing a pivotal part in cancer aetiology. One might reasonably surmise from this that carcinogens found in our environment or diet are culpable. Exposure to carcinogens is associated with various forms of DNA damage such as single-stand breaks, double-strand breaks, covalently bound chemical DNA adducts, oxidative-induced lesions and DNA–DNA or DNA–protein cross-links. This review predominantly concentrates on DNA damage induced by the following carcinogens: polycyclic aromatic hydrocarbons, heterocyclic aromatic amines, mycotoxins, ultraviolet light, ionising radiation, aristolochic acid, nitrosamines and particulate matter. Additionally, we allude to some of the cancer types where there is molecular epidemiological evidence that these agents are aetiological risk factors. The complex role that carcinogens play in the pathophysiology of cancer development remains obscure, but DNA damage remains pivotal to this process.

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Prostate biopsy findings in Indian men: A hospital-based study

Abstract: Cancer is less common and inflammatory lesions more common at all levels of PSA in our patients. The effect of antibiotics on PSA and biopsy in our patients needs to be explored.

Cited by 13 publications

References 8 publications

Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

Histopathological evaluation of clinically diagnosed prostatic lesions.

Carcinogens and DNA damage

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