Antibacterial synergy between rutin and florfenicol enhances therapeutic spectrum against drug resistant Aeromonas hydrophila

Deepika, M; Thangam, Ramar; Vijayakumar, T.; Sasirekha, R.; Vimala, R.T.V.; Srinivasan, Sivasubramanian; Sridhar, Arun; Babu, M.; Ramasamy, Thirumurugan

doi:10.1016/j.micpath.2019.103612

Cited by 38 publications

(18 citation statements)

References 91 publications

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“…After 24 h incubation, the 96-well plates were showed with more turbidity at increasing concentration. When the concentration was increased that the inhibition activity also increased in 96-well plates of treated wells ( Deepika et al, 2019 ). The result was indicated that the chitosan loaded essential oil has antibacterial activity at lowest concentration.…”

Section: Resultsmentioning

confidence: 99%

Anti-bacterial activity of chitosan loaded plant essential oil against multi drug resistant K. pneumoniae

Zhang

Ramachandran

Mothana

et al. 2020

Saudi Journal of Biological Sciences

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The development of antibiotic resistant in K. pneumoniae is an emerging thread worldwide due to the poor antimicrobial drugs. To overcome this issue, researchers are focused on plant material and their essential oils to fight against multi drug resistant bacteria. In this context, the current study was concentrated in medicinal plant of guva leaves and their essential oils to combat multi drug resistant bacterial infections. The essential oils were successfully screened and confirmed by HRLC-MS analysis. The anti-bacterial ability of the compounds were loaded into the chitosan nanoparticles and proved by FT-IR analysis. In addition, the chitosan loaded essential oils morphology was compared with chitosan alone in SEM analysis and suggested that the material was loaded successfully. Further, the anti-bacterial ability of the chitosan loaded essential oils were primarily confirmed by agar well diffusion method. At the 100 µg/mL of lowest concentration of chitosan loaded essential oils, the multi-drug resistant K. pneumoniae was inhibited with 96% and confirmed by minimum inhibition concentration experiment. Hence, all the experiments were proved that the essential oils were successfully loaded into the chitosan nanoparticles, and it has more anti-bacterial activity against multi-drug resistant K. pneumoniae.

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Section: Resultsmentioning

confidence: 99%

Anti-bacterial activity of chitosan loaded plant essential oil against multi drug resistant K. pneumoniae

Zhang

Ramachandran

Mothana

et al. 2020

Saudi Journal of Biological Sciences

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“…Also, this extract contained elevated levels of rutin, a compound with good antibacterial potential [8]. Different antibacterial effects are mentioned for rutin, with a greater inhibitory activity determined against S. aureus compared to E. coli [64], but also against Aeromonas hydrophyla [5]. This also applies to V. major and V. major var.…”

Section: Discussionmentioning

confidence: 95%

“…Antibiotic-resistant bacteria and invasive malignant tumors are two of the most challenging, contemporary problems that scientists are constantly attempting to overcome [1,2]. Since the gene for antibiotic resistance in bacteria was identified to be present also in an ancient strain [3], far before antibiotics were even discovered, resources were increasingly directed towards alternative means of treatment [4,5]. At the same time, chemotherapeutic drugs remain the main treatment administered in cancer patients, even if the side effects are well-known and thoroughly documented [6].…”

Section: Introductionmentioning

confidence: 99%

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

et al. 2021

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The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts showed species-dependent antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. Vincamine was present in V. minor, V. major, and V. major var. variegata, while V. minor had the richest alkaloid content, followed by V. herbacea. V. major var. variegata was richest in flavonoids and the highest total phenolic content was found in V. herbacea which also had elevated levels of rutin. Consequently, V. herbacea had the highest antioxidant activity followed by V. major var. variegata. Whereas, the lowest one was of V. major. The V. minor extract showed the most efficient inhibitory effect against both Staphylococcus aureus and E. coli. On the other hand, V. herbacea had a good anti-bacterial potential only against S. aureus, which was most affected at morphological levels, as indicated by scanning electron microscopy. The Vinca extracts acted in a dose-depended manner against HaCaT keratinocytes and A375 melanoma cells and moreover, with effects on the ultrastructure, nitric oxide concentration, and lactate dehydrogenase release. Therefore, the Vinca species could be exploited further for the development of alternative treatments in bacterial infections or as anticancer adjuvants.

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“…The extensive use of rutin in clinical treatments has been received much attention [1,2]. Rutin has antibacterial [3], antiviral [4], anti-tumor [5], and anti-in ammatory [6] properties. Furthermore, it has effective physiological functions and it has an effective role in diluting the blood [7] and lowering blood pressure [8].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical determination of rutin by using NiFe2O4 nanoparticles loaded reduced graphene oxide

Askari

Salarizadeh

Askari

2021

Preprint

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A binary transition metal oxide based on nickel and iron (NiFe2O4) and hybridization of this nanomaterial with reduced graphene oxide (rGO) are synthesized by the hydrothermal method. X-ray diffraction (XRD), and Raman spectroscopy confirm the successful synthesis of these materials. Also, scanning electron microscope (SEM) and transmission electron microscope (TEM) images illustrated the particle morphology with the particle size of 20 nm. The synthesized material is then examined as a sensor on the surface of the glassy carbon electrode to detect a very small amount of rutin .Some electrochemical tests such as cyclic voltammetry, differential pulse voltammetry, impedance spectroscopy indicate the remarkable accuracy of this sensor and its operation in a relatively wide range of concentration of rutin (100 nM-100 µM). Considering the very good results, it seems the NiFe2O4-rGO can be considered as a new proposal in the development of accurate and inexpensive electrochemical sensors.

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Antibacterial synergy between rutin and florfenicol enhances therapeutic spectrum against drug resistant Aeromonas hydrophila

Cited by 38 publications

References 91 publications

Anti-bacterial activity of chitosan loaded plant essential oil against multi drug resistant K. pneumoniae

Anti-bacterial activity of chitosan loaded plant essential oil against multi drug resistant K. pneumoniae

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

Electrochemical determination of rutin by using NiFe2O4 nanoparticles loaded reduced graphene oxide

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