“…First disclosed in 1884, the Pechmann condensation is a classic method for synthesizing coumarins. , Likewise, the Biginelli reaction is a classic method for synthesizing dihydropyrimidin-2 H -ones (DHPs), which was first reported in 1891. − These two reactions were chosen because they both involved multiple acid-mediated synthetic steps, and the heterocyclic products of both reactions are important scaffolds for the synthesis of bioactive agents. The coumarin family of molecules have shown antioxidant, antibiotic, antiviral, and antitumor activities. − Likewise, DHPs are valuable synthetic targets because they have been shown to have similar pharmacological properties, as well as antiepileptic and antimalarial activities. − Numerous condensation conditions have been developed for the synthesis of these heterocyclic targets. A common motif in these condensations is the harsh acidic activating agents that are often employed, such as POCl 3 and polyphosphoric acid, that lead to issues with corrosion and environmental impact…”