Synthesis, Characterization and Biological Evaluation of 4-(4-Bromo-1-Hydroxy Naphthalen-2-Yl)-6-(4-Methoxy Phenyl)-5,6-Dihydropyrimidine-2(1h)-One

Abstract

1-(4- Bromo -1-hydroxynaphthalen-2-yl)-ethan-1-one was prepared by refluxing 4- bromonaphthalen-1-ol with glacial acetic acid in presence of fused ZnCl2. By condensing 1-(4- bromo -1-hydroxynaphthalen-2- yl)-ethan-1-ones with 4- methoxy benzaldehyde, to prepared by 1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one were synthesized.1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one, urea and concentrated HCl in DMF were added and refluxed. Cool and pour in crushed ice. Treat it with cold NH4OH solution to obtain titled compounds. The compounds thus synthesized have been characterized by physical and spectral data. All of these titled synthesized compounds have been screened for antimicrobial study and are found to possess excellent antimicrobial activities.

Synthesis, Characterization and Biological Evaluation of 6-(5-Chloro-8-Hydroxynapthalene-2-yl)-4(4-Hydroxyphenyl)-4-5-Dihydroxypyrimidin-2(1h)-One

“…The simplest and most common method for the synthesis one pot three component reaction involving the condensation reaction with benzaldehyde, ethylacetoacetate and urea [11][12] . The newly synthesized chloro-substitituted dihydropyridine derivative have an interesting biological activity such as antitumor 13 , anticancer 14 , antihypertensive 15 , antifungal 16 , calcium channel blockers 17 ,antioxidant 18 ,anti-microbial 19 , anti-inflammatory 20…”