Antibacterial reactive liposomes encapsulating coupled enzyme systems

Jones, Malcolm N.; Hill, Kate J.; Kaszuba, Michael; Creeth, Jonathan E.

doi:10.1016/s0378-5173(97)00418-3

Cited by 24 publications

(20 citation statements)

References 16 publications

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“…This strategy was evaluated for the treatment of S. gordonii biofilms. [71,72] Glucose oxidase (GO) was incorporated into DPPC:PI liposomes, as well as GO combined with horse radish peroxidase (HRP), GO combined with chloroperoxidase (CPO) or GO combined with lactoperoxidase (LPO). The liposomes strongly adsorbed on the S. gordonii biofilms due to the presence of PI in the liposomes.…”

Section: Non-specific Targetingmentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

360

320

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Biofilms are matrix-enclosed communities of bacteria that show increased antibiotic resistance and the capability to evade the immune system. They can cause recalcitrant infections which cannot be cured with classical antibiotic therapy. Drug delivery by lipid or polymer nanoparticles is considered a promising strategy for overcoming biofilm resistance. These particles are able to improve the delivery of antibiotics to the bacterial cells, thereby increasing the efficacy of the treatment. In this review we give an overview of the types of polymer and lipid nanoparticles that have been developed for this purpose. The antimicrobial activity of nanoparticle encapsulated antibiotics compared to the activity of the free antibiotic is discussed in detail. In addition, targeting and triggered drug release strategies to further improve the antimicrobial activity are reviewed. Finally, ample attention is given to advanced microscopy methods that shed light on the behavior of nanoparticles inside biofilms, allowing further optimization of the nanoformulations. Lipid and polymer nanoparticles were found to increase the antimicrobial efficacy in many cases. Strategies such as the use of fusogenic liposomes, targeting of the nanoparticles and triggered release of the antimicrobial agent ensured the delivery of the antimicrobial agent in close proximity of the bacterial cells, maximizing the exposure of the biofilm to the antimicrobial agent. The majority of the discussed papers still present data on the in vitro anti-biofilm activity of nanoformulations, indicating that there is an urgent need for more in vivo studies in this field.

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Section: Non-specific Targetingmentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

360

320

View full text Add to dashboard Cite

show abstract

“…193 This concept could be applied to other peroxidases (Scheme 8), yielding different oxyacids with different antibacterial properties. 194 The single encapsulation of GOx has been studied in detail, not only as reactor but also as a glucose biosensor. 195 The idea of incorporating catalytically active species in the aqueous compartment of a liposome can also be applied to larger membrane structures, that is, giant vesicles.…”

Section: Reactions In the Inner Compartment Of Vesiclesmentioning

confidence: 99%

Self-Assembled Nanoreactors

et al. 2005

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“…HOSCN is also produced by the SPO-catalyzed oxidation of SCN -by H 2 O 2 (Ihalin et al, 2006 ;Nagy et al, 2006a). HOSCN is antimicrobial toward oral bacteria (Path D) (Clem and Klebanof, 1966;Hoogendoorn, 1976;Pruitt et al, 1979;Carlsson et al, 1983;Thomas et al, 1983Thomas et al, , 1994bEllen et al, 1988;Lopatin et al, 1991;Lumikari et al, 1991;Courtois et al, 1992;Lenander-Lumikari et al, 1993, 1997van der Hoeven and Camp, 1993;Kirstila et al, 1994;Jones et al, 1998;Courtois, 1999, 2001;Yu et al, 2000;Ihalin et al, 2001Ihalin et al, , 2003Korpela et al, 2002;Garcia-Graells et al, 2003;Vannini et al, 2004), but relatively non-injurious to the host (Bjoerck and Claesson, 1980;Marshall and Reiter, 1980;White et al, 1983;Carlsson et al, 1984;Carlsson, 1987).…”

Section: Spatial Nature Of Peroxidase Systems and Their Consensus Submentioning

confidence: 99%

Inorganic Chemistry of Defensive Peroxidases in the Human Oral Cavity

Ashby

2008

J Dent Res

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The innate host response system is comprised of various mechanisms for orchestrating host response to microbial infection of the oral cavity. The heterogeneity of the oral cavity and the associated microenvironments that are produced give rise to different chemistries that affect the innate defense system. One focus of this review is on how these spatial differences influence the two major defensive peroxidases of the oral cavity, salivary peroxidase (SPO) and myeloperoxidase (MPO). With hydrogen peroxide (H2O2) as an oxidant, the defensive peroxidases use inorganic ions to produce antimicrobials that are generally more effective than H2O2 itself. The concentrations of the inorganic substrates are different in saliva vs. gingival crevicular fluid (GCF). Thus, in the supragingival regime, SPO and MPO work in unison for the exclusive production of hypothiocyanite (OSCN−, a reactive inorganic species), which constantly bathes nascent plaques. In contrast, MPO is introduced to the GCF during inflammatory response, and in that environment it is capable of producing hypochlorite (OCl−), a chemically more powerful oxidant that is implicated in host tissue damage. A second focus of this review is on inter-person variation that may contribute to different peroxidase function. Many of these differences are attributed to dietary or smoking practices that alter the concentrations of relevant inorganic species in the oral cavity ( e.g.: fluoride, F−; cyanide, CN−; cyanate, OCN−; thiocyanate, SCN−; and nitrate, NO3−). Because of the complexity of the host and microflora biology and the associated chemistry, it is difficult to establish the significance of the human peroxidase systems during the pathogenesis of oral diseases. The problem is particularly complex with respect to the gingival sulcus and periodontal pockets (where the very different defensive stratagems of GCF and saliva co-mingle). Despite this complexity, intriguing in vitro and in vivo studies are reviewed here that reveal the interplay between peroxidase function and associated inorganic chemistry.

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Antibacterial reactive liposomes encapsulating coupled enzyme systems

Cited by 24 publications

References 16 publications

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Self-Assembled Nanoreactors

Inorganic Chemistry of Defensive Peroxidases in the Human Oral Cavity

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