2008
DOI: 10.1177/154405910808701003
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Inorganic Chemistry of Defensive Peroxidases in the Human Oral Cavity

Abstract: The innate host response system is comprised of various mechanisms for orchestrating host response to microbial infection of the oral cavity. The heterogeneity of the oral cavity and the associated microenvironments that are produced give rise to different chemistries that affect the innate defense system. One focus of this review is on how these spatial differences influence the two major defensive peroxidases of the oral cavity, salivary peroxidase (SPO) and myeloperoxidase (MPO). With hydrogen peroxide (H2O… Show more

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Cited by 99 publications
(96 citation statements)
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References 247 publications
(272 reference statements)
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“…the gingival sulcus), it is disfavoured in the part of the oral Abbreviations: bLPO, bovine milk lactoperoxidase; CLSM, confocal laser scanning microscopy; CV, crystal violet; DTNB, 5,59-dithio-bis(2-nitrobenzoic acid); hMPO, human myeloperoxidase; HRP, horseradish peroxidase; hSPO, human salivary peroxidase; LPO, lactoperoxidase. (Ashby, 2008). We have employed bovine milk lactoperoxidase (bLPO), a readily available enzyme, as a surrogate for hSPO.…”
Section: Introductionmentioning
confidence: 99%
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“…the gingival sulcus), it is disfavoured in the part of the oral Abbreviations: bLPO, bovine milk lactoperoxidase; CLSM, confocal laser scanning microscopy; CV, crystal violet; DTNB, 5,59-dithio-bis(2-nitrobenzoic acid); hMPO, human myeloperoxidase; HRP, horseradish peroxidase; hSPO, human salivary peroxidase; LPO, lactoperoxidase. (Ashby, 2008). We have employed bovine milk lactoperoxidase (bLPO), a readily available enzyme, as a surrogate for hSPO.…”
Section: Introductionmentioning
confidence: 99%
“…the gingival sulcus), it is disfavoured in the part of the oral cavity that is controlled by saliva (Ashby, 2008). Instead, hSPO and hMPO work in unison in the supragingival regime to exclusively oxidize thiocyanate (SCN 2 ) to produce hypothiocyanite (OSCN 2 , a reactive inorganic species), which constantly bathes early oral plaques (Ashby, 2008). We have employed bovine milk lactoperoxidase (bLPO), a readily available enzyme, as a surrogate for hSPO.…”
Section: Introductionmentioning
confidence: 99%
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“…The nitrate (NO3 -) nitrogen (N) form has a low level of acute toxicity but it can be transformed into the nitrite N (NO2 -) form, which has much higher acute toxicity (Santamaria, 2006). It has been estimated that about 4-8% of the nitrate from the diet may be reduced to nitrite by the micro flora in the oral cavity (Ashby, 2008;Lundberg and Weitzberg, 2009). Some studies have shown that nitrate exposure is correlated with gastric cancer risk due to the endogenous formation of N-nitroso compounds (Jakszyn and González, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…NaOH-stabilized sodium hypochlorite could have a stronger tissue-dissolving effect compared to the standard preparation. The reason for this is that the OCl -/HOCl equilibrium adjusts itself exceedingly fast in non-stabilized solutions (13). In contact with microorganisms or tissues, the pH drops, so that…”
Section: Introductionmentioning
confidence: 99%